Goiter

This study tests whether a wearable goggle system that makes parathyroid glands glow can help surgeons find and protect them during thyroid removal. About 280 adults having thyroid surgery will take part. The goal is to reduce the risk of low calcium levels after surgery, a commo…

This study tests an investigational drug called efgartigimod for adults with Graves' disease whose thyroid levels are still high despite taking standard antithyroid medications. About 230 participants will receive either the drug or a placebo as a shot under the skin. The goal is…

This study tests a drug called efgartigimod, given as a shot under the skin, for adults with Graves' disease whose thyroid levels are still too high despite taking standard antithyroid drugs. About 230 people will take part, and some will get the drug while others get a placebo. …

This phase 4 trial tests whether two traditional Chinese medicines, Xiaojin Pill and Neixiao Luoli Pill, can safely reduce the size of benign or low-risk thyroid nodules. About 108 adults aged 18 to 65 will be randomly assigned to take one of the pills or receive only lifestyle a…

This study will test whether a special MRI technique called T1 mapping can find and measure tiny scars in the heart muscle of people with long-term thyroid disease. The goal is to see if this non-invasive scan can replace the need for a heart biopsy. The study plans to enroll 40 …

This study tests whether taking vitamin D3 along with calcium for a week before total thyroidectomy prevents symptomatic low calcium levels after surgery better than calcium alone. 124 adults with multinodular goiter will be randomly assigned to one of the two groups. After surge…

This phase 2 trial tests a dye called bevonescein that makes nerves glow during thyroid surgery, helping surgeons see and avoid them. Forty adults having thyroid removal will receive the dye before surgery. The main goal is to see if it improves voice outcomes by reducing nerve i…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study compares two tools used during thyroid removal surgery: LigaSure and bipolar diathermy. The goal is to see which one leads to shorter surgery time, less pain, and fewer complications. Thirty adults having partial or total thyroid removal will take part.

This study tests a computer vision model called PTAIR that helps surgeons identify parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery. About 100 adults with thyroid disease will take part. The model's ability to spot these structures will be compa…

This study will measure how much of the pesticide chlordecone is stored in the thyroid and nearby fat tissue of 69 adults having thyroid surgery in Guadeloupe. Researchers will also look at blood levels and ask about diet and job history to see what factors affect accumulation. T…

This study tests whether giving breastfeeding mothers a daily iodine-containing multivitamin for 6 months helps their babies' brains and thyroid health. Researchers will compare babies' brain activity and development between moms who get the supplement and those who receive stand…