Goiter

This study tests a drug called IMVT-1402 in adults with Graves' disease, a condition where the immune system attacks the thyroid. The goal is to see if the drug can help patients stay healthy without needing other treatments. About 372 people who completed earlier studies will ta…

This study tests a drug called TOUR006 in 79 people with active thyroid eye disease, a condition that causes eye bulging and inflammation. Participants receive either a low dose, high dose, or placebo injection every 8 weeks. The main goal is to see if the drug can reduce eye bul…

This study tests whether a personalized low-calorie Mediterranean-style diet, combined with lifestyle coaching, can prevent people newly diagnosed with Graves' disease from regaining too much weight after their thyroid levels normalize. Fifty-four adults will be randomly assigned…

This study tests a new, less invasive treatment for large thyroid nodules (giant nodular goiter) that cause discomfort or breathing problems. The procedure uses a tiny tube to deliver a chemotherapy drug (bleomycin) directly into the nodule's blood supply, blocking it and shrinki…

This registry study follows 100 adults who have had a procedure called thyroid embolization to treat hyperthyroidism, goiter, or thyroid nodules. The procedure uses a catheter to block blood flow to the thyroid, aiming to shrink it and reduce symptoms. Researchers will track chan…

This study looks at whether proteins found in urine can help doctors diagnose follicular thyroid cancer before surgery. Currently, this type of thyroid cancer can only be confirmed after removing the thyroid. Researchers will collect urine samples from 50 patients with thyroid no…

This study looks at whether a tailored exercise program can improve quality of life, muscle strength, and balance in women aged 65 and older with Hashimoto's thyroiditis or multinodular toxic goiter. Participants will be randomly assigned to either the exercise program or usual c…

This study tests if a single session of radiofrequency ablation (using heat) can safely shrink benign (non-cancerous) thyroid nodules in 106 adults. The goal is to reduce symptoms like neck pressure or cosmetic concerns. Participants will be followed for a year to measure nodule …

This study tests whether placing a placental-based allograft called Amnioeffect on the surgical wound improves scar appearance, pain, and swallowing after thyroid or parathyroid surgery. About 334 adults will be enrolled, with half receiving the graft and half getting standard ca…

This study looks at how thyroid problems impact pain, tiredness, foot shape, muscle strength, and leg function in women who have regular periods. Researchers will compare 51 women with thyroid issues to healthy women to see what differences exist. The goal is to better understand…

This study compares two methods of monitoring the nerve that controls the vocal cords during thyroid and parathyroid surgery. The standard method uses a breathing tube with electrodes, while the new method uses tiny needles placed directly into the voice box cartilage. Researcher…

This study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not.…

This study examines autoimmune hyperthyroidism in children diagnosed before age 6, focusing on their symptoms, growth, and response to treatment. Researchers will compare these young children with older children who have the same condition. The goal is to identify patterns that c…

This study looks at whether COVID-19 vaccination might trigger Graves' disease, a condition where the immune system attacks the thyroid. Researchers will review medical records of 161 people who developed Graves' disease for the first time between March 2020 and October 2022. The…

This study aimed to see if thyroid surgery changes the thickness of the carotid artery, which is a sign of heart disease risk. It planned to measure artery thickness before and after surgery in adults with various thyroid conditions. However, the study was withdrawn before enroll…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

This study compares a new 3D ultrasound technology (PIUR) with standard 2D ultrasound for measuring thyroid nodule size after ablation. Researchers want to see if the 3D method gives more accurate and consistent results. About 75 adults who are having thyroid nodule ablation will…