New injection every 8 weeks shows promise for thyroid eye disease

NCT ID NCT06088979

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called TOUR006 in 79 people with active thyroid eye disease, a condition that causes eye bulging and inflammation. Participants receive either a low dose, high dose, or placebo injection every 8 weeks. The main goal is to see if the drug can reduce eye bulging by at least 2 millimeters without worsening the other eye.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

endocrine exophthalmos exophthalmos eye disorder Graves disease Graves Ophthalmopathy hyperthyroidism thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Academy of Diabetes, Thyroid, and Endocrine - Site 840-129

    El Paso, Texas, 79935, United States

  • Al-Essra Hospital - Site 400-401

    Amman, Jordan

  • Azienda Ospedaliera Universitaria Federico II - Site 390-382

    Naples, 80131, Italy

  • Azienda Ospedaliero Universitaria Pisana - Site 380-381

    Pisa, 56124, Italy

  • Bascom Palmer Eye Institute - Site 840-115

    Miami, Florida, 33136, United States

  • CHU Angers - Site 250-252

    Angers, 49933, France

  • CHU de Nantes - Hopital Nord Laennec - Site 250-251

    Nantes, 44800, France

  • Catalina Eye Care - Site 840-121

    Tucson, Arizona, 85712, United States

  • Centro Brasileiro de Pesquisa Clínica - Rio de Janeiro Ltd - Site 076-765

    Rio de Janeiro, 22410-000, Brazil

  • Columbia University - Site 840-125

    New York, New York, 10032, United States

  • DCT Fort Worth Research Center - Site 840-133

    Fort Worth, Texas, 76132, United States

  • Foothill Eye Institute - Site 840-116

    Pasadena, California, 91107, United States

  • Freire Pesquisa Clinica - Site 076-773

    Belo Horizonte, 13334-290, Brazil

  • Hackensack University Medical Center - Site 840-105

    Hackensack, New Jersey, 07601, United States

  • Hospital Universitario Ramon y Cajal - Site 724-803

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena - Site 724-801

    Seville, 41009, Spain

  • IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia - Site 076-761

    São Paulo, 04038-032, Brazil

  • Irmandade da Santa Casa de Misericordia de Sao Paulo - Site 076-771

    São Paulo, 01221-020, Brazil

  • Kahana Oculoplastic and Orbital Surgery - Site 840-112

    Livonia, Michigan, 48152, United States

  • NPCRS - Nucleo de Pesquisa Clinica do Rio Grande do Sul - Site 076-764

    Porto Alegre, 90430-001, Brazil

  • Ophthalmic Consultants of Boston - Site 840-128

    Boston, Massachusetts, 02114, United States

  • Ophthalmic Plastic, Reconstructive, Orbital & Cosmetic Surgery - Site 840-123

    Las Vegas, Nevada, 89144, United States

  • Riga East Clinical University Hospital, Clinic Bikernieki - Site 428-901

    Riga, LV1006, Latvia, Latvia

  • Santa Casa de Misericordia de Porto Alegre - Site 076-767

    Porto Alegre, 90020-090, Brazil

  • Seoul National University Hospital - Site 410-002

    Seoul, 03080, South Korea

  • Southern Eye Specialists Ltd - Site 554-501

    Christchurch, 8013, New Zealand

  • Sun Research Institute - Site 840-120

    San Antonio, Texas, 78215, United States

  • The Pacific Center for Oculofacial and Aesthetic Plastic Surgery - Site 840-122

    San Francisco, California, 94115, United States

  • UC Hospital Sue Anschulz-Rodgers Eye Center - Site 840-101

    Aurora, Colorado, 80045, United States

  • UFG - Hospital de Clinicas da Universidade Federal de Goias - Site 076-762

    Goiânia, 74605-050, Brazil

  • Universidade Federal do Rio Grande do Sul (UFRGS) - Site 076-775

    Porto Alegre, 90410-000, Brazil

  • University of California Davis Eye Center - Site 840-119

    Sacramento, California, 95817, United States

  • University of Puerto Rico, Medical Sciences Campus - Site 630-602

    San Juan, 00921, Puerto Rico

  • University of West Virginia - Site 840-113

    Morgantown, West Virginia, 26506, United States

  • Univerzitna nemocnica Bratislava - Nemocnica sv. Cyrila a Metoda - Site 703-211

    Bratislava, 851 07, Slovakia

  • Ziemelkurzemes Regional Hospital - Site 428-902

    Ventspils, Latvia