Disorder of facial skeleton

This study compares two surgical techniques to repair a bone gap in the upper jaw (alveolar cleft) in 20 people who missed earlier treatment. One method uses bone from the patient's jaw, the other from the hip. Researchers will measure bone volume and shape after 6 months to see …

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This study tests whether adding metformin gel to a standard bone graft improves bone quality in children aged 8 to 12 with a cleft in the upper jaw (alveolar cleft). 36 participants will be randomly assigned to receive either the metformin-enhanced graft or a placebo. The main go…

This phase 2 trial tests a combination of two drugs (Benmelstobart and Anlotinib) plus targeted radiation (SBRT) in 29 adults with liver cancer that has spread to a few other spots and no longer responds to first-line treatment. The goal is to see if this triple therapy can slow …

This study compares two surgical techniques for repairing bilateral alveolar clefts (gaps in the upper jaw) using bone grafts from the hip. Twenty participants will receive either a solid bone block or loose bone chips. The goal is to see which method provides better bone volume …

This study compares a new stem-cell-based kit to the standard bone graft surgery for repairing gaps in the upper jaw (alveolar cleft) in children aged 6 to 11 with cleft lip and palate. The kit uses stem cells from baby teeth combined with a special material to help bone grow. Th…

This study tests whether alternating injections of a steroid (triamcinolone) and platelet-rich plasma (PRP) can improve mouth opening and reduce burning pain in people with oral submucous fibrosis, a condition that causes stiffness and can lead to cancer. Forty adults with modera…

This study tests a lower dose of radiation (12 Gy in 6 sessions) for people with low-grade B-cell orbital lymphoma, a slow-growing eye cancer. The goal is to see if this dose can control the tumor as well as the standard higher dose (24-25 Gy) while causing fewer long-term side e…

This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study aims to see if online speech therapy works as well as face-to-face sessions for children aged 5 to 11 with repaired cleft palate. Sixty-four children will receive 30-minute speech therapy twice a week for 10 weeks, either online or in person. Researchers will measure i…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether teaching speech and language skills to infants with unrepaired cleft palate can improve their communication before palate repair surgery. Two hundred infants aged 6 to 10 months will join weekly coaching sessions with their families. The goal is to see if…

This study looks at how a standard laryngoscope blade (Macintosh) works during breathing tube placement in 100 adults with normal mouth opening. The goal is to gather measurements that may later help doctors manage patients with restricted mouth opening from submucous fibrosis. R…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will use MRI scans to see how well the palate and throat muscles work after a special surgery for cleft palate repair. The surgery uses a piece of cheek muscle to close the gap and aims to improve speech. Ten people who have not had early treatment will get the surgery…

This study looks at whether using a flap from the cheek (FAMM flap) helps bone grow better when repairing a cleft in the gum area. Five people aged 9 to 20 who already had braces to widen the palate will be included. Researchers will use 3D X-rays to measure bone height, width, a…

This study looks at how surgery for a rare brain tumor called craniopharyngioma might change what foods people like, especially fatty and sugary ones. Researchers will compare food preferences of 346 adults who had this surgery with two other groups: people who had a different pi…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study compares two established techniques for placing a TAVI heart valve to see which one better aligns the valve with the patient's own valve openings, reducing the risk of blocking coronary arteries. Forty patients with severe aortic stenosis will be randomly assigned to o…

This study uses CT scans to see how a deviated nasal septum (a crooked wall inside the nose) affects the size of the maxillary sinuses and the chance of developing sinusitis. Researchers will compare the deviated side to the normal side in 120 adults. The goal is to better unders…