Disorder of facial skeleton

This trial asks whether it is safe to skip the routine removal of impacted teeth before radiation therapy for nasopharyngeal carcinoma. Half of the participants will have the extraction as usual, while the other half will not. The study will compare the risk of jaw bone damage (o…

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This study compares a new stem-cell-based kit to the standard bone graft surgery for repairing gaps in the upper jaw (alveolar cleft) in children aged 6 to 11 with cleft lip and palate. The kit uses stem cells from baby teeth combined with a special material to help bone grow. Th…

This study compares two surgical techniques to repair a bone gap in the upper jaw (alveolar cleft) in 20 people who missed earlier treatment. One method uses bone from the patient's jaw, the other from the hip. Researchers will measure bone volume and shape after 6 months to see …

This study tests whether adding metformin gel to a standard bone graft improves bone quality in children aged 8 to 12 with a cleft in the upper jaw (alveolar cleft). 36 participants will be randomly assigned to receive either the metformin-enhanced graft or a placebo. The main go…

This phase 2 trial tests a combination of two drugs (Benmelstobart and Anlotinib) plus targeted radiation (SBRT) in 29 adults with liver cancer that has spread to a few other spots and no longer responds to first-line treatment. The goal is to see if this triple therapy can slow …

This study compares two surgical techniques for repairing bilateral alveolar clefts (gaps in the upper jaw) using bone grafts from the hip. Twenty participants will receive either a solid bone block or loose bone chips. The goal is to see which method provides better bone volume …

This study tests whether alternating injections of a steroid (triamcinolone) and platelet-rich plasma (PRP) can improve mouth opening and reduce burning pain in people with oral submucous fibrosis, a condition that causes stiffness and can lead to cancer. Forty adults with modera…

This study tests a lower dose of radiation (12 Gy in 6 sessions) for people with low-grade B-cell orbital lymphoma, a slow-growing eye cancer. The goal is to see if this dose can control the tumor as well as the standard higher dose (24-25 Gy) while causing fewer long-term side e…

This study is developing an artificial intelligence (AI) system that can analyze standard MRI brain scans to determine the specific molecular subtype of a child's brain tumor before surgery. The research includes 1,400 children under 18 with suspected brain tumors, using both pas…

This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half…

This study aims to see if online speech therapy works as well as face-to-face sessions for children aged 5 to 11 with repaired cleft palate. Sixty-four children will receive 30-minute speech therapy twice a week for 10 weeks, either online or in person. Researchers will measure i…

This study tests whether teaching speech and language skills to infants with unrepaired cleft palate can improve their communication before palate repair surgery. Two hundred infants aged 6 to 10 months will join weekly coaching sessions with their families. The goal is to see if…

This study looks at different presurgical treatments for infants born with cleft lip and palate. These treatments help shape the mouth and nose before surgery. Researchers will compare how well each approach works, how many clinic visits are needed, and how much burden it places …

This study looks at how a standard laryngoscope blade (Macintosh) works during breathing tube placement in 100 adults with normal mouth opening. The goal is to gather measurements that may later help doctors manage patients with restricted mouth opening from submucous fibrosis. R…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study will use MRI scans to see how well the palate and throat muscles work after a special surgery for cleft palate repair. The surgery uses a piece of cheek muscle to close the gap and aims to improve speech. Ten people who have not had early treatment will get the surgery…

This study looks at whether using a flap from the cheek (FAMM flap) helps bone grow better when repairing a cleft in the gum area. Five people aged 9 to 20 who already had braces to widen the palate will be included. Researchers will use 3D X-rays to measure bone height, width, a…

This study looks at how surgery for a rare brain tumor called craniopharyngioma might change what foods people like, especially fatty and sugary ones. Researchers will compare food preferences of 346 adults who had this surgery with two other groups: people who had a different pi…

This study compares two established techniques for placing a TAVI heart valve to see which one better aligns the valve with the patient's own valve openings, reducing the risk of blocking coronary arteries. Forty patients with severe aortic stenosis will be randomly assigned to o…

This study uses CT scans to see how a deviated nasal septum (a crooked wall inside the nose) affects the size of the maxillary sinuses and the chance of developing sinusitis. Researchers will compare the deviated side to the normal side in 120 adults. The goal is to better unders…