Cytomegalovirus infection

This study tested an experimental mRNA vaccine (mRNA-1647) for cytomegalovirus (CMV) in healthy teens (9–15 years) and young women (16–25 years). The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the vaccine or a placeb…

This study tested a vaccine called Triplex® in 94 adults who have both HIV and cytomegalovirus (CMV). The goal was to see if the vaccine is safe and helps the immune system control CMV. Participants received two shots of the vaccine or a placebo over 4 weeks and were followed for…

This study tested an experimental mRNA vaccine called mRNA-1647 to see if it is safe and triggers an immune response against cytomegalovirus (CMV). The trial involved 315 healthy adults aged 18 to 40, some of whom had never been exposed to CMV. Researchers measured side effects a…

This study tested the safety and immune response of several Moderna mRNA vaccines for COVID-19, seasonal flu, RSV, and CMV in 308 healthy adults aged 18 to 75. Researchers monitored side effects and measured antibody levels after vaccination. The goal was to ensure the vaccines a…

This early-stage trial tests a new vaccine against cytomegalovirus (CMV), a common virus that can cause serious problems in newborns and people with weakened immune systems. The study involves 339 healthy adults aged 18 to 50, who will receive different doses of the vaccine or a …

This study is a long-term follow-up of a phase 2 trial testing Moderna's mRNA-1647 vaccine against cytomegalovirus (CMV). It involves 135 adults who previously received the vaccine or a placebo. Researchers are checking how long the immune response lasts and whether a booster dos…

This early-stage trial tests a new vaccine called SPYVLP01 designed to protect against cytomegalovirus (CMV), a common virus that can cause serious problems in newborns and people with weak immune systems. The study involves 120 healthy adults aged 18 to 50 and will check if the …

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study tested two different medicines to prevent CMV infection in 70 kidney transplant patients at high risk. One group received the standard drug valganciclovir, while the other received maribavir plus acyclovir. The goal was to see which approach caused fewer side effects l…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested whether giving the antiviral drug valacyclovir to pregnant women with a CMV-infected fetus could reduce the chance of the baby being born with serious symptoms. 41 pregnant women took high doses of valacyclovir daily for up to 23 weeks. The goal was to see if th…

This study tested whether giving patients special immune cells (T cells) that target CMV or adenovirus could control these infections after a stem cell transplant. Sixteen children and adults received one or two doses of these cells. The goal was to reduce virus levels in the blo…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether newborns who fail their hearing screening can be diagnosed with congenital CMV infection and have a full hearing test before they turn one month old. Researchers tested 235 babies to see how quickly they could get results. The goal is to improve early…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a new blood test that looks for a tiny piece of the CMV virus's genetic material (a microRNA) in 60 patients who had a stem cell transplant. The goal was to see if this test could detect CMV reactivation earlier or more accurately than the standard DNA test. Res…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study tested the drug letermovir to prevent CMV infection in 15 adults who had a lung transplant for idiopathic pulmonary fibrosis (IPF). Participants took letermovir daily for 6 or 12 months depending on their CMV risk. The goal was to see if the drug could prevent CMV infe…

This study tested whether teaching pregnant women about CMV risks and protective behaviors could prevent them from catching the virus. 582 women were enrolled early in pregnancy. The intervention involved brief counseling sessions. The goal was to reduce CMV infections that can c…

This study tests whether teaching pregnant women about hygiene habits can reduce their risk of catching cytomegalovirus (CMV) and passing it to their baby. Researchers will enroll 200 pregnant women in Brazil and provide counseling on behaviors like handwashing. The goal is to cu…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This study looked at whether a simple saliva test can find cytomegalovirus (CMV) in children aged 3 months to 6 years. Researchers collected saliva samples from 655 children in daycares and a hospital emergency department. The goal was to see how common the virus is and to check …

This study looked at 236 kidney transplant patients to find out why some fail to develop immune protection against cytomegalovirus (CMV) in the first 45 days after surgery. Researchers reviewed medical records to compare patients who had a strong immune response with those who di…

This study looked at 800 children and adults who received a liver transplant in China to learn how often they get infected with cytomegalovirus (CMV), a common virus that can cause serious problems after transplant. Researchers tracked patients for one year, checking for CMV infe…

This study looked at how the drug letermovir passes from a pregnant woman to her fetus during the second trimester. Seven women who were already scheduled to end their pregnancy for other reasons took part. The goal was to measure drug levels in fetal blood and amniotic fluid to …

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to …

This study looked at whether having patients collect a small blood sample at home (using a finger prick) and getting reminders on their phone could help them stick to weekly testing for cytomegalovirus (CMV) after a stem cell transplant. About 150 transplant recipients took part.…

This study looked at 139 children having a colonoscopy to see how often the CMV virus is found in their gut tissue and blood. Some children had inflammatory bowel disease (Crohn's or colitis) and some did not. The goal was to learn which tests best detect CMV in the gut, helping …

This study reviewed medical records of 330 kidney transplant patients in the UK to understand how cytomegalovirus (CMV) infections are managed. Researchers looked at how common these infections are, what treatments were used, and how well they worked. The goal was to gather infor…

This study followed 400 stem cell transplant recipients to see how well anti-CMV medications work in everyday hospital care. Researchers tracked infections, drug resistance, and side effects. The goal was to gather real-life data to improve treatment guidelines for these high-ris…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested whether saliva samples can be used to remotely monitor cytomegalovirus (CMV) infection in people receiving treatment for ovarian cancer. Researchers compared saliva and blood samples from 49 participants, collected either at the clinic or at home. The goal was t…

This study looked at 254 newborns with congenital cytomegalovirus (CMV) infection to find early signs that predict hearing loss or other brain-related problems at age 1. Researchers used clinical exams, brain scans, and lab tests to build a scoring system. The goal is to help doc…