Cytomegalovirus infection

This study tests an mRNA vaccine (mRNA-1647) to prevent cytomegalovirus (CMV) infection in people who have had a stem cell transplant. About 84 participants will receive either the vaccine or a placebo. The goal is to see if the vaccine can safely prevent CMV after stopping stand…

This phase II trial tests a vaccine designed to protect stem cell transplant recipients from cytomegalovirus (CMV), a common virus that can cause serious illness in people with weakened immune systems. The vaccine uses a modified, harmless virus to deliver three CMV proteins, tra…

This study tests a vaccine called Triplex to prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV is usually harmless but can be life-threatening for people with weakened immune systems. The vaccine uses harmless virus pieces to train th…

This trial is testing whether specially grown T cells from cord blood can help prevent or treat infections caused by common viruses (CMV, EBV, BKV, and adenovirus) in people who have had a cord blood transplant. The study aims to find the safest and most effective dose of these v…

This study follows 75 adults who have had a stem cell or solid organ transplant and are being treated with maribavir for cytomegalovirus (CMV) infection. Researchers will track how well the drug clears the virus, how long treatment lasts, and any side effects. The goal is to see …

This phase 2 trial tests whether immune cells from donors who have been exposed to CMV can treat persistent CMV infections in patients who have had a stem cell transplant. The study includes 49 participants with CMV that hasn't improved with standard antiviral drugs. The cells ar…

This trial tests whether adding a single dose of CytoGam—a concentrated antibody product against cytomegalovirus (CMV)—to standard antiviral drugs helps clear CMV from the blood faster in solid organ transplant recipients. The study enrolls adults aged 18–75 who have received an …

This study tests whether specially grown immune cells can fight three common viruses—adenovirus, CMV, and EBV—in people whose immune systems are weak due to a stem cell or organ transplant, or an inherited immune disorder. The cells are made from a donor's blood and trained to re…

This study tests whether a newer drug, letermovir, works better and causes fewer side effects than the standard drug valganciclovir for preventing CMV infection in African American kidney transplant recipients. About 30 high-risk patients will take letermovir for 6 months after t…

This study looks at two different approaches to prevent cytomegalovirus (CMV) infection in people who have received a kidney transplant from a living donor. The participants are at intermediate risk for CMV and are given standard anti-rejection medication. The goal is to see whic…

This study tests a modified plan to prevent and treat cytomegalovirus (CMV) infection in people with blood cancers who have had a donor stem cell transplant. CMV is a common virus that can cause serious problems after transplant. The study involves 153 participants and looks at w…

This study tests whether a CMV-specific T cell immunity test can help doctors decide how long to give letermovir to prevent late CMV infection after a stem cell transplant. About 250 adults with blood cancers who had a first transplant will take part. The goal is to see if using …

This study tests a new way to treat viral infections that often occur after a solid organ transplant. Researchers create special immune cells, called viral-specific T-cells, from the patient's own blood to fight the virus. The goal is to reduce the need for strong anti-viral drug…

This early-phase study tests whether vaccinating stem cell donors against cytomegalovirus (CMV) can prevent the virus from causing problems in blood cancer patients after a transplant. About 34 donor-recipient pairs are taking part. The vaccine is given to the donor before stem c…

This study looks at how the immune system's T cells respond to two common herpesviruses—cytomegalovirus (CMV) and varicella-zoster virus (VZV)—in people who have had a liver transplant. Because transplant recipients take drugs that suppress their immune system to prevent organ re…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This study is for adults receiving a kidney, lung, liver, or heart transplant. It will collect blood and tissue samples to learn how the body responds to CMV, a common virus that can cause serious problems after transplant. The goal is to better understand the virus and improve f…