Cleft palate
MONDO:0016064Cleft palate is a fissure type embryopathy that affects the soft and hard palate to varying degrees.
Also known as: palatoschisis, uranostaphyloschisis
67 clinical trials for this condition and its sub-types.
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Broader categories
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New putty could replace painful bone grafts for kids with cleft palate
Disease control CompletedThis study tested a new calcium phosphate putty to repair bone gaps in the gums of 84 children with unilateral cleft lip and palate. The putty was compared to the standard approach of using the child's own bone. Researchers measured how much bone remained after one year, as well …
Phase: NA • Sponsor: UMC Utrecht • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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New jaw expander could improve smiles for kids with cleft lip and palate
Disease control CompletedThis study tested a new device called the Leaf Self Expander to widen the upper jaw in 20 children with cleft lip and palate. The device was compared to the standard rapid maxillary expander. Researchers used 3D scans to measure changes in bone and tooth position. The goal was to…
Phase: NA • Sponsor: Al-Azhar University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Fat graft patch boosts palate hole repair in cleft patients
Disease control CompletedThis study tested a new surgical technique for repairing a common complication after cleft palate surgery: a hole (fistula) in the roof of the mouth. In 36 patients, half received the standard two-layer repair, while the other half also had a small piece of fat from the cheek pla…
Phase: NA • Sponsor: Tanta University • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Nerve block may cut opioid use in Kids' cleft palate surgery
Symptom relief CompletedThis study tested whether a special nerve block given during cleft palate repair can lower pain and reduce the need for opioids in children. Forty children having their first cleft palate surgery received the nerve block. Researchers measured pain scores and opioid use to see if …
Phase: NA • Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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New drug calms kids after cleft palate surgery
Symptom relief CompletedThis study tested whether a single dose of dexmedetomidine, given during surgery, can prevent severe agitation in children aged 1-7 after cleft palate repair. Sixty children were randomly assigned to receive either the drug or a placebo (saline). The main goal was to measure emer…
Phase: PHASE3 • Sponsor: Assiut University • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Jaw implants aim to boost life quality after surgery
Symptom relief CompletedThis study looked at how well Global D implants work for orthognathic (jaw) surgery and whether they improve patients' quality of life. 198 people who had their first jaw surgery received these implants. Researchers measured quality of life before and after surgery using a specia…
Sponsor: Global D • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Rare genetic disorder studied for clues to better care
Knowledge-focused CompletedThis study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Honey vs. antibiotic: which heals cleft palate surgery better?
Knowledge-focused CompletedThis study looked at whether a special honey (Trigona sp.) helps heal wounds after cleft palate surgery better than a standard antibiotic dressing. Twenty-four children aged 18 months to 6.5 years participated. Researchers measured a healing marker in saliva before and after surg…
Phase: NA • Sponsor: Hasanuddin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Cleft Surgery's hidden impact on palate blood flow revealed
Knowledge-focused CompletedThis study looked at how routine cleft repair surgery changes blood flow in the roof of the mouth. Researchers used a non-invasive probe to measure oxygen levels in the tissue before and after surgery in 77 patients. The goal was to understand the surgery's effect on tissue healt…
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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French kids help set new standard for diagnosing speech disorders
Knowledge-focused CompletedThis study measured normal nasalance scores in 131 French-speaking children aged 8 to 10 using a non-invasive device called a Nasometer. The goal is to create reference values that help doctors diagnose velopharyngeal dysfunction, a common issue in children with cleft palate, wit…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Gene sequencing uncovers mysterious fetal malformations
Knowledge-focused CompletedThis study tested whether a powerful DNA test called high-throughput exome sequencing can find genetic causes of multiple birth defects in fetuses when standard exams fail. Researchers studied 100 fetuses with at least two malformations and no prior diagnosis. They compared the n…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Speedy gene test aims to give answers on birth defects in just 7 days
Knowledge-focused CompletedThis study tested whether a fast type of genetic test called rapid genome sequencing can find the cause of birth defects seen on ultrasound more quickly than current methods. Researchers included 184 pregnancies with certain ultrasound findings. The goal was to see if results cou…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC