Chronic liver failure

This trial tests whether a device called VitaSmart, which pumps cold, oxygenated preservation fluid through a donor liver before transplant, can reduce early organ dysfunction and improve survival compared with the usual method of simply storing the liver on ice. About 228 adults…

This study looked at whether it is safe to transplant livers from deceased HIV-positive donors into HIV-positive recipients. Researchers followed 80 participants to track complications like graft failure, infections, and HIV breakthrough. The goal was to see if using HIV-positive…

This study tests whether a single infusion of donor-derived regulatory dendritic cells (DCreg) can help living donor liver transplant recipients safely stop taking immunosuppression drugs. Participants are low-risk patients who are 1 to 3 years post-transplant. They receive the D…

This study tested whether livers from donors with hepatitis C could be safely transplanted into people without hepatitis C. Five patients on the liver transplant waiting list received these livers and were then treated with an antiviral drug to prevent infection. The goal was to …

This study looked at how the HIV drug raltegravir works in people with severe liver disease who need a liver transplant. It included 14 HIV-positive adults with end-stage liver failure. Researchers checked how the drug behaves in the body and how it interacts with anti-rejection …

This study tested whether umbilical cord stem cells given through a vein could help people with end-stage liver disease. Twenty-two adults received different doses to see if it improved survival and liver function. The goal was to find a safer, more accessible alternative to live…

This study tested whether multiple infusions of stem cells from donated umbilical cords could help people with end-stage liver disease. 92 adults received the stem cells through a vein, and researchers tracked liver function and complications. The goal was to see if repeated dose…

This study tested whether giving both midodrine (a blood-pressure drug) and albumin (a protein infusion) to children with cirrhosis and fluid buildup (ascites) could prevent serious complications like kidney injury, low sodium, and confusion. Sixty-one children were split into tw…

This study looked at whether donated livers that were not perfect (called extended criteria donor livers) could be safely used for transplant after being treated with a special machine that pumps fluids through them. The goal was to see if these livers would work well and last a …

This study tested whether giving growth hormone to people with decompensated liver cirrhosis (advanced liver scarring) could improve their health and survival. The trial included 96 adults with this condition. Researchers measured how long patients survived without major complica…

This study tested a device that pumps cold, oxygenated fluid through donor livers before transplant. The goal was to see if it reduces early organ damage in livers from older or higher-risk donors. 266 liver transplant patients took part. The approach could help more people get s…

This study tested whether an infusion of special immune cells (regulatory dendritic cells) from the donor could help liver transplant recipients safely reduce their anti-rejection medications. Sixteen low-risk patients received the cell infusion a week before transplant, then fol…

This study compares two machines that clean the blood of toxins when the liver fails: MARS (a standard system) and SPAD (a simpler, cheaper alternative). Thirty-four patients with severe liver failure will try both machines in random order. The goal is to see if SPAD works as wel…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study tests whether giving methadone and ketamine during a deceased donor liver transplant can lower pain and confusion after surgery. About 50 adults will receive either the drug combo or standard care. Researchers will track pain scores, opioid use, and recovery time.

This study tested whether a personalized home exercise program (walking three times a week and strength training with elastic bands twice a week) could improve fitness and strength in 30 adults waiting for a liver transplant. The goal was to see if better fitness before surgery c…

This study tested whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty-four adult patients received either the block or a sham procedure after surgery. Researchers measured how much morphine patients neede…

This study tested two approaches to bring palliative care (comfort-focused care) to people with end-stage liver disease. About 1,500 adults from 19 U.S. centers took part. One group had direct access to a palliative care specialist; the other group saw a liver doctor specially tr…

This study tests whether an Apple Watch, combined with artificial intelligence, can detect early signs of improvement or deterioration in people with advanced chronic liver disease (cirrhosis). Participants wear the watch to continuously track heart rate, oxygen levels, sleep, ac…

This study investigates how a single dose of mavorixafor is processed in people with mild to moderate liver impairment compared to healthy volunteers with normal liver function. Researchers will measure drug levels in the blood and monitor safety and tolerability. The goal is to …

This study looks at whether participating in a routine physiotherapy program after a liver transplant leads to better physical and cognitive outcomes about a year later. Researchers compared liver transplant recipients who did physiotherapy with those who did not, measuring balan…

This study looked at how the body handles a drug called BI 1584862 in people with different levels of liver function. 43 adults with mild, moderate, or severe liver problems, plus a group with healthy livers, took a single dose of the drug. Researchers measured drug levels in the…

This study looked at 446 liver transplant patients to see if changes in their MELD score (a measure of liver disease severity) could predict who might not survive. Researchers focused on patients with high MELD scores, who are at greater risk. The goal is to better understand how…

This study looked at how the experimental drug iclepertin (BI 425809) is processed in people with and without liver problems. 29 adults aged 18-79 took a single dose of the drug. Researchers measured drug levels in the blood and monitored safety to see if liver impairment changes…

This pilot study looked at 38 liver transplant patients to see if liver failure lowers blood levels of pyrophosphate, a natural substance that prevents calcium buildup in tissues. Researchers measured pyrophosphate before and after transplant and checked liver tissue for a relate…

This study looked at how a new U.S. policy for distributing donated livers (started in 2020) affected costs for liver transplants at one hospital in Dallas. Researchers compared costs and transplant volumes for 186 patients before and after the policy change. The goal was to unde…

This study aimed to create new mathematical models to better predict which patients with severe liver disease are at highest risk of dying while waiting for a liver transplant. Researchers analyzed data from 501 adults on the French national transplant waiting list. The goal is t…

This completed study looked at 574 hospitalized adults with end-stage liver disease to see if alcoholic patients had the same chance of getting on the national liver transplant waiting list as non-alcoholic patients. The goal was to find out if non-medical reasons limit access fo…

This study tested whether a non-invasive light sensor (near-infrared spectroscopy) placed on the skin over the kidney could measure oxygen levels during liver transplant surgery. Researchers monitored 41 patients to see if this method gives useful information about kidney functio…

This study looked at over 1,100 liver transplant patients to see if having a donor of a different gender affects long-term survival. Researchers followed patients for up to 10 years after transplant. The goal is to understand whether gender mismatch is a risk factor, which could …

This completed study looked at 300 liver transplant cases to understand why donor livers with fatty liver disease are more likely to be injured after transplantation. Researchers compared genetic activity in archived tissue samples from 50 cases, using advanced techniques to iden…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This pilot study tested a program called the Liver Live Donor Champion Program for people waiting for a liver transplant. The program trains a friend or family member to be an advocate and help the patient find a living donor. Researchers enrolled 76 liver transplant candidates a…

This study looked at 82 adults getting a liver transplant to see if using a special blood test called ROTEM helps doctors manage bleeding better than standard tests. The goal was to see if ROTEM could reduce the amount of blood products given during surgery. Researchers tracked c…

This study compared two surgical tools—surgical loupes (magnifying glasses) and a microscope—for repairing bile ducts during living donor liver transplants. 52 adults receiving a right-lobe liver graft with a single bile duct opening took part. The goal was to see which tool led …

This study looks at how the drug BI 1015550 is absorbed and processed in the blood of people with mild or moderate liver problems compared to those with healthy livers. About 28 adults took a single dose and had blood samples taken over several days. The goal is to understand if …

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This completed Phase 1 study looked at how imlunestrant, an oral drug, enters the bloodstream and leaves the body in women with and without liver impairment. 27 female participants took a single dose, and researchers measured drug levels over time. The goal is to understand if li…

This study from Mayo Clinic looked at 97 liver transplant patients to see how often they had lasting muscle weakness after surgery when given sugammadex, a drug to reverse anesthesia. Researchers used a device called TetraGraph to measure muscle response. The goal was to estimate…