Chromosome 21 disorder

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tests whether a type of physical therapy called Neurodevelopmental Treatment (NDT) can help preschool children with Down syndrome improve their balance, mobility, and walking ability. Twenty children aged 3 to 6 years will receive individualized NDT sessions twice a we…

This large phase 3 trial enrolled over 9,000 children with newly diagnosed standard-risk B-ALL or localized B-LLy. Researchers tested different combinations and doses of chemotherapy drugs to see which worked best with the fewest side effects. The goal was to improve disease-free…

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This study tested a personalized surgical approach for children with obstructive sleep apnea who have small tonsils or Down syndrome. Instead of the standard tonsil and adenoid removal, doctors used a sleep endoscopy to see exactly where the airway collapses and chose surgeries b…

This completed study tested whether a special diet plus a nutritional supplement called T-2 could improve thinking skills, sleep, and overall health in 76 people with Down syndrome, autism, or ADHD, aged 2 to 35. Participants followed either the diet alone, the diet plus suppleme…

This study tested a new blood test to diagnose Down syndrome (trisomy 21) in pregnant women without the risks of invasive procedures like amniocentesis. Researchers collected blood samples from 150 pregnant women at high risk and analyzed fetal cells. The goal is to provide a saf…

This study tested a new blood test that looks at fetal DNA in the mother's blood to detect Down syndrome (trisomy 21) as early as the first trimester. Researchers enrolled 976 pregnant women at high risk and compared the blood test results to standard invasive methods. The goal w…

This study compared a simple blood test (noninvasive prenatal testing, or NIPT) with the standard invasive procedure (amniocentesis or chorionic villus sampling) for detecting Down syndrome in over 2,100 pregnant women at high risk. The goal was to see if NIPT could reduce miscar…

This study looked at whether extra family support helps children with Down syndrome and obstructive sleep apnea use their positive airway pressure (PAP) machine more regularly. 27 children aged 6-18 were split into two groups: one received standard care, the other got a family-in…

This study looked at whether a 10-week supervised physical activity program is practical and well-liked by mothers of children with developmental disabilities. Nineteen mothers were enrolled to attend three 60-minute group exercise sessions per week. The goal was to see if the pr…

This completed study tested whether playing an aerobic-based virtual reality game (exergame) on Xbox Kinect could improve physical fitness, functional capacity, and cognitive function in 44 adults with Down syndrome, compared to traditional treadmill exercise. Participants did ei…

This study tested a program called Babble Boot Camp for infants with Down syndrome, who often start talking late. 60 babies under 12 months old took part. Parents were trained by a speech therapist via video calls to do simple activities at home to boost their child's speech and …

This pilot study tested a 12-week yoga program in 15 children with Down syndrome aged 7–12. The program included adapted poses, breathing, and relaxation exercises. Researchers measured balance and functional performance using digital sensors and movement tests. The goal was to s…

This study tested a behavioral therapy called JASPER in 103 children with Down syndrome, ages 3 to 7. The therapy focuses on improving joint attention, play, and social communication through caregiver coaching. Researchers compared it to a self-directed learning program to see wh…

This study tested whether a 12-week online dance program is practical and enjoyable for young adults with Down Syndrome. Twenty participants joined two 35-minute group dance sessions each week. Researchers measured attendance, safety, and changes in fitness and thinking skills. T…

This study tested whether a 12-session program combining yoga and support groups could reduce stress for caregivers of young adults with intellectual and developmental disabilities. Twenty caregivers participated, and researchers measured stress levels, cortisol, and how many ses…

This completed study looked at whether orofacial therapy (exercises for the mouth and face) or therapeutic yoga could improve swallowing, sleep habits, and quality of life in 30 children with Down syndrome aged 5 to 12. All children continued their usual physical therapy, with so…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study looked at whether using eye drops to dilate (widen) the pupils before measuring vision leads to better eyeglass prescriptions for people with Down syndrome. 42 participants had their vision tested with and without dilation. The goal was to see which method gives sharpe…

This study looked at how young children with Down syndrome, cerebral palsy, and other motor delays move and explore when using a powered mobility device called the Explorer Mini and a bodyweight support system. Sixteen children who could sit upright but not walk 10 feet on their …

This study created a new questionnaire called the Down Syndrome Health Instrument (DHI) to measure health in people with Down syndrome. Researchers worked with caregivers, individuals with Down syndrome, and experts to develop and test the tool. Over 750 participants took part in…

This study interviewed 28 parents in Reunion Island who had a child with Down Syndrome to understand why they chose not to terminate the pregnancy. Researchers wanted to learn about the beliefs, values, and cultural or economic factors behind this decision. The goal is to shed li…

This study looked at how exercise training changes blood flow and work capacity in 60 adults with Down syndrome. Participants were generally healthy but sedentary. The goal was to understand if exercise can improve how the heart and blood vessels work during activity. Results may…

This study adapted a test called the Segmental Assessment of Trunk Control (SATCo) into Turkish and checked if it works well for infants with Down syndrome. Researchers tested 27 infants to see if the tool reliably measures trunk control, which is important for motor development.…

This study tested an 8-week online nutrition education program for 31 people with Down syndrome and their 31 caregivers. The program aimed to improve eating habits and nutrition knowledge. Results showed changes in dietary behaviors and intake after the program.

This completed study with 40 participants explored factors that might predict obstructive sleep apnea in people with Down syndrome. Researchers used a range of assessments, including sleep studies, heart monitoring, and exercise tests, to identify early warning signs. The goal is…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This completed study of over 7,000 pregnant women looked at whether the father's age influences the chance of Down syndrome (trisomy 21) in the baby. While it's well known that the mother's age matters, the father's role is less clear. Researchers used a blood test called the Opt…

This study looked at how early motor experiences—like reaching, grasping, and moving—affect thinking, language, and gesture development in infants with Down syndrome. Researchers observed 51 infants aged 7 to 36 months to see if better motor skills lead to stronger cognitive and …

This study looked at whether doing spatial activities like puzzles, block building, and hide-and-seek can improve mental rotation and perspective-taking in people with Down syndrome. 84 adolescents and young adults with Down syndrome, plus typically developing children, took part…

This completed study from Cairo University surveyed 240 Egyptian families of children with Down Syndrome to find out how much they know about physical therapy. The goal was to identify gaps in awareness so that better education and support can be provided. The study did not test …