Carotid stenosis

This study compares two ways to perform carotid artery stenting—a procedure that opens narrowed neck arteries to prevent stroke. The standard method uses an artery in the groin, while the experimental method uses an artery in the wrist. Researchers will enroll 3000 adults with si…

This study looked back at 199 people who already received the Precise Pro Rx stent to treat narrowed carotid arteries (the main arteries in the neck). Researchers wanted to see how well the stent worked and if there were any serious problems like stroke, heart attack, or death. T…

This study tested a new device that combines a stent, a filter to catch debris, and a balloon in one system for treating narrowed carotid arteries. It involved 178 patients at high risk for standard surgery. The main goal was to see if the device reduces the chance of stroke, hea…

This study tested a simple procedure called remote ischemic conditioning (RIC) in 100 people with narrowed neck arteries who were having surgery to clear the blockage. RIC involves briefly inflating a blood pressure cuff on both arms to temporarily stop blood flow, then releasing…

This study tested a procedure called TCAR to treat blocked carotid arteries (major neck arteries). 55 patients with severe blockages were treated, and researchers used brain scans to check for new small brain lesions after the procedure. The goal was to see how safe the procedure…

This study tested whether a 6-month home-based walking program could reduce dangerous bleeding inside carotid artery plaque in people with significant blockages but no stroke symptoms. Fifty-six participants either followed an individualized step goal (with coaching) or received …

This completed trial enrolled 2,486 people with asymptomatic high-grade carotid stenosis (narrowing of the neck arteries) to see if adding surgery or stenting to intensive medical management reduces stroke risk more than medical management alone. Participants were randomly assign…

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study tested a special PET/MR scan using a radioactive tracer called 18F-sodium fluoride to see if it can better identify dangerous carotid artery plaques. The researchers compared 6 patients who recently had a stroke with 6 who had no symptoms, all with significant plaque b…

This completed clinical trial tested a procedure called ischemic postconditioning to prevent brain damage in 40 people undergoing carotid surgery for severe artery narrowing. The procedure involves briefly clamping and unclamping the carotid artery in cycles after surgery to prot…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This study looks at people with severe but symptom-free narrowing of the carotid artery in the neck. It tests whether opening the artery with surgery or stenting can improve memory and thinking problems caused by poor blood flow to the brain. About 385 participants from a larger …

This completed study analyzed microRNAs in carotid artery plaques from 30 patients who had surgery to remove them. Researchers compared plaques from people who had already had a stroke (symptomatic) with those who had not (asymptomatic) to see if certain microRNAs are linked to s…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This study looked at 129 patients who had surgery to clear blocked neck arteries, a common cause of stroke. Doctors compared two surgical techniques—the eversion method and the conventional method—to see which had fewer complications like stroke or artery re-blockage within 30 da…

This study looked back at the medical records of 200 people who had artery repair surgery using the Uni-Graft K DV patch. The goal was to see how often the artery narrowed again after surgery and to check for any bleeding or strokes. The study did not give any new treatment, but …

This study looked at 206 patients who had carotid artery surgery to see if the hyoid bone (a small bone in the neck) is linked to artery narrowing and stroke. Researchers used CT scans to measure the distance and position between the hyoid bone and the carotid artery. The goal wa…

This study looked at how well people think and remember after surgery to clear a blocked neck artery (carotid endarterectomy). About 800 patients took brain tests before and after surgery, and their results were compared to people having spine surgery. The goal was to find out ho…

This completed Phase 4 trial tested whether xenon gas (LENOXe) can keep blood pressure as stable as sevoflurane during carotid artery surgery in 84 elderly patients. The study measured blood pressure changes every minute during surgery. Researchers also looked at safety, recovery…