Candidiasis

This Phase 2 trial tested whether adding interferon-gamma to standard antifungal treatment helps clear Candida from the blood faster. 65 adults with candidemia received the drug or standard care alone. The study is completed, and results will show if this combination is safe and …

This study tested whether using blood biomarkers (beta-D-glucan and mannan) can help doctors safely stop antifungal drugs earlier in critically ill patients suspected of a fungal infection. 192 ICU patients were randomly assigned to either a biomarker-guided strategy or standard …

This study tested a new oral medication, oteseconazole, to see if it can prevent recurrent yeast infections in women who have had at least three infections in the past year. Over 400 participants took either the study drug or a placebo for 12 weeks after an initial treatment, and…

This study tested a new oral medication, oteseconazole, to see if it can prevent recurrent yeast infections in women who have had at least three infections in the past year. Participants first received standard treatment for their current infection, then took either oteseconazole…

This study tested a device that uses UVA and blue light to treat bacterial vaginosis and yeast infections. 38 women received one or two light treatments. Researchers checked if symptoms improved and if the vaginal microbiome became healthier. The goal is to find an alternative to…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a vaginal pessary (Gedea) in 26 women with yeast infections. Participants used the device daily for 6 days. Researchers checked if symptoms like itching and burning went away by day 7 to 14. The goal was to see if the device could safely treat the infection with…

This study tested an experimental drug called APX001 in 21 adults with Candida bloodstream infections, including cases where standard antifungals might not work. Participants received the drug for up to 14 days, with possible follow-up treatment. The goal was to see if the drug c…

This Phase 2 trial tested an experimental antifungal drug called APX001 (fosmanogepix) in 9 adults with blood or deep-organ infections caused by Candida auris, a fungus that often resists standard treatments. The drug was given by IV or mouth for up to 42 days. The goal was to se…

This study compared two antifungal drugs, fluconazole and micafungin, in 100 newborns with suspected or confirmed candidiasis. The goal was to see if micafungin works as well as the standard treatment fluconazole and to check their safety. The study also looked at how the drugs b…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This study looked at whether combining several blood tests can detect serious fungal infections (candidemia) faster and more accurately than standard methods. Researchers tested 2 hospitalized adults with suspected fungal infections using both routine blood cultures and newer tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at a blood test called Beta-D-glucan (BDG) to see how well it detects invasive fungal infections in people with weak immune systems. Researchers tested 280 patients and checked if two positive results within 15 days confirmed an infection. The goal is to help do…

This study tested a new medicine called rezafungin to see if it can prevent serious fungal infections in adults getting a bone marrow transplant. About 600 participants received either rezafungin or the standard treatment. The goal was to see if rezafungin helps more people stay …

This study looked at whether it's safe to reduce or stop antifungal drugs early in immunocompromised ICU patients suspected of having a fungal infection. Researchers tracked 275 patients across 14 ICUs to see how often doctors de-escalated treatment and what factors influenced th…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at how the antifungal drug micafungin is processed in the bodies of 60 critically ill ICU patients with invasive candidiasis. Researchers took multiple blood samples to measure drug levels and understand why some patients might not get enough medicine. The goal …

This study looked at better ways to detect Candida (a type of fungus) infections early in intensive care unit (ICU) patients. Researchers tested 422 non-neutropenic adults who had been in the ICU for more than 48 hours. They used four different tests, including blood tests and sw…

This study looked at whether a substance called β-D-glucan in the blood can help identify and track fungal infections in the abdomen (peritonitis) in intensive care patients. Researchers measured levels in 70 adults with peritonitis, comparing those with and without Candida yeast…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…

This study looked at whether a special type of PET scan can help doctors diagnose and treat a rare fungal infection of the liver and spleen in people with blood cancer or those who had a stem cell transplant. The infection often appears after severe neutropenia (low white blood c…