New hope against Drug-Resistant fungal infections?

NCT ID NCT03604705

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 31 times

Summary

This study tested a new antifungal drug called APX001 in 21 adults with a serious bloodstream fungal infection (candidemia), including cases where standard treatments might not work. Participants received the drug for up to 14 days, with possible extra treatment afterward. The goal was to see if the infection cleared and if the drug was safe.

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Contacts and locations

Locations

  • Augusta University (Georgia Regents University)

    Augusta, Georgia, 30901, United States

  • CHU de Charleroi - Hopital Civil Marie Curie

    Lodelinsart, Belgium

  • Duke University Hospital Medical Center

    Durham, North Carolina, 27710, United States

  • Hopital Erasme

    Brussels, 1070, Belgium

  • Hospital General Universitario de Alicante

    Alicante, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Mutua de Terrassa

    Terrassa, Barcelona, Spain

  • Hospital VLL D Hebron

    Barcelona, Spain

  • Infectious Diseases Unit

    Tel Aviv, 6423906, Israel

  • Infectious Diseases Unit, Rambam Medical Center

    Haifa, 3109601, Israel

  • Infectious Diseases Unit,Sheba Medical Center

    Tel Litwinsky, 52621, Israel

  • Institut Jules Bordet

    Brussels, Belgium

  • Institut Jules Bordet,Service De Microbiologie

    Brussels, 1000, Belgium

  • Klinik I fur Innere Medizin- Uniklinik Koln

    Cologne, Germany

  • Mont-Godinne University Hospital

    Yvoir, 5530, Belgium

  • Rambam Medical Center

    Haifa, Israel

  • Sheba Medical Center

    Tel Litwinsky, Israel

  • Sourasky Medical Center

    Tel Aviv, Israel

  • Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz - III. Medizinische Klinik Haematologie/Onkologie

    Mainz, Germany

  • Universite Libre de Bruxelles (ULB) - Hopital Erasme

    Brussels, Belgium

  • University Hospital Heidelberg

    Heidelberg, Germany

  • University Hospital Mont-Godinne

    Yvoir, Belgium

  • University of Alabama at Birmingham (UAB)

    Birmingham, Alabama, 35249, United States

  • University of Alabama at Birmingham School of Medicine

    Birmingham, Alabama, 35233, United States

  • University of California, Davis

    Davis, California, 95616, United States

  • University of California-Davis Medical Center

    Sacramento, California, 95817, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Texas- Health Science Center and Medical School at Houston

    Houston, Texas, 77030, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.