New hope against Drug-Resistant yeast infections?
NCT ID NCT03604705
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested an experimental drug called APX001 in 21 adults with Candida bloodstream infections, including cases where standard antifungals might not work. Participants received the drug for up to 14 days, with possible follow-up treatment. The goal was to see if the drug could clear the infection and improve survival. Results will help decide if larger studies are warranted.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
APX001 (an experimental antifungal drug)
What this could lead to
If successful, this could point toward a new treatment option for serious Candida bloodstream infections, especially those resistant to current antifungals.
What could go wrong
This is a very small, early-phase trial with only 21 participants and no comparison group. The drug may not prove effective or safe in larger studies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Augusta University (Georgia Regents University)
Augusta, Georgia, 30901, United States
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CHU de Charleroi - Hopital Civil Marie Curie
Lodelinsart, Belgium
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Duke University Hospital Medical Center
Durham, North Carolina, 27710, United States
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Hopital Erasme
Brussels, 1070, Belgium
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Hospital General Universitario de Alicante
Alicante, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Mutua de Terrassa
Terrassa, Barcelona, Spain
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Hospital VLL D Hebron
Barcelona, Spain
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Infectious Diseases Unit
Tel Aviv, 6423906, Israel
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Infectious Diseases Unit, Rambam Medical Center
Haifa, 3109601, Israel
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Infectious Diseases Unit,Sheba Medical Center
Tel Litwinsky, 52621, Israel
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Institut Jules Bordet
Brussels, Belgium
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Institut Jules Bordet,Service De Microbiologie
Brussels, 1000, Belgium
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Klinik I fur Innere Medizin- Uniklinik Koln
Cologne, Germany
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Mont-Godinne University Hospital
Yvoir, 5530, Belgium
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Rambam Medical Center
Haifa, Israel
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Sheba Medical Center
Tel Litwinsky, Israel
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Sourasky Medical Center
Tel Aviv, Israel
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Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz - III. Medizinische Klinik Haematologie/Onkologie
Mainz, Germany
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Universite Libre de Bruxelles (ULB) - Hopital Erasme
Brussels, Belgium
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University Hospital Heidelberg
Heidelberg, Germany
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University Hospital Mont-Godinne
Yvoir, Belgium
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University of Alabama at Birmingham (UAB)
Birmingham, Alabama, 35249, United States
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University of Alabama at Birmingham School of Medicine
Birmingham, Alabama, 35233, United States
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University of California, Davis
Davis, California, 95616, United States
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University of California-Davis Medical Center
Sacramento, California, 95817, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Texas- Health Science Center and Medical School at Houston
Houston, Texas, 77030, United States
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Washington University
St Louis, Missouri, 63110, United States