Brain aneurysm

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study looks at a device called ENTERPRISE 2 that helps doctors treat brain aneurysms (a bulging blood vessel in the brain). The device is used during a procedure to block the aneurysm with coils. The study includes 164 people aged 18 to 80 with certain types of brain aneurys…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study tests a device called the Surpass Evolve Flow Diverter, a small mesh tube placed inside an artery to redirect blood flow away from a brain aneurysm. The goal is to safely close the aneurysm and prevent it from rupturing. About 248 adults with unruptured, wide-neck aneu…

This study tests a device called the Contour System to treat brain aneurysms (weak spots in blood vessels that can burst). The device is placed inside the aneurysm to block blood flow and prevent rupture. The trial involves 250 adults aged 18-75 with a specific type of aneurysm. …

This study follows 500 people who received the Surpass Evolve flow diverter, a device placed in brain arteries to treat aneurysms. Researchers will track safety and effectiveness for up to 5 years, focusing on stroke risk and aneurysm closure. The goal is to confirm the device wo…

This study is testing a new device called the Citadel Embolization Device, a coil used to block blood flow in brain aneurysms. It involves 150 adults aged 18-80 with unruptured or recently ruptured wide-neck aneurysms. The goal is to see if the device safely and effectively seals…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study follows 195 adults who received the WEB device, a mesh implant used to block blood flow into wide-neck brain aneurysms. Researchers are checking how well the device works and its safety over one year. The goal is to confirm that the device remains a reliable option for…

This study is testing a device called FRED X, a small mesh tube placed inside an artery to block blood flow to a brain aneurysm. The goal is to see if it works as well as the earlier FRED device in preventing strokes and sealing the aneurysm. About 154 participants with a single …

This early study tests a new, experimental device called the HARBOR Occlusion Device for treating brain aneurysms. Ten adults with a single unruptured brain aneurysm will receive the device to see if it safely and effectively blocks blood flow to the aneurysm. The goal is to prev…

This study is testing a device called the Pipeline™ Flex Embolization Device with Shield Technology™ to treat wide-necked brain aneurysms. The device is a small mesh tube that is placed inside the artery to divert blood flow away from the aneurysm, helping it heal. The study will…

This study follows 246 people who received the Pipeline Shield device to treat brain aneurysms. The device is a small mesh tube that blocks blood flow to the aneurysm, reducing rupture risk. Researchers are checking how well the aneurysm seals, whether the artery narrows, and if …

This study tests a new device called SEAL™ that is placed inside a brain aneurysm to block blood flow and prevent rupture. About 279 adults with unruptured or recently ruptured aneurysms are taking part. The goal is to see if the device safely and effectively seals the aneurysm w…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study is checking whether the Accero stent is safe and works well for people with brain aneurysms. Researchers are following 130 patients who already received the stent as part of routine care. They will use imaging and disability scales to see how patients do over time.

This study tests a procedure that uses tiny coils to block blood flow in brain aneurysms (bulging blood vessels). The goal is to seal the aneurysm and prevent rupture. About 164 people with aneurysms 4-14mm in size are being followed for one year after treatment.

This study tests a drug-coated stent designed to block blood flow into unruptured brain aneurysms, helping them heal. Researchers will follow 280 patients for 12 months after the stent is placed, checking how well the aneurysm closes and watching for any complications. The goal i…

This study is testing the safety and effectiveness of a device called Silk Vista, used to treat brain aneurysms (a bulging blood vessel that can burst). Researchers are following 234 patients who already received the device as part of their normal care. The goal is to see how wel…

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study tests whether an AI program can find unruptured brain aneurysms on standard CT scans that people already get for other reasons. Ten adults with risk factors (like high blood pressure or being over 40) will have their scans checked by AI and then by a radiologist. The g…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study looks at how social factors like income, education, and lifestyle might influence the risk of a brain aneurysm bursting. Researchers will analyze data from 1,800 patients using artificial intelligence to find patterns. The goal is to improve risk prediction and help pr…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study looks at how often nurses should check on people in the ICU after they have had a brain aneurysm treated. The goal is to see if checking every hour versus every two hours affects how well patients sleep. Thirty adults who had a planned aneurysm coiling will take part, …

This study uses MRI scans to check for hidden brain aneurysms in close relatives (parents, siblings, or children) of people who have had a bleeding aneurysm. It aims to find who is at higher risk and how lifestyle factors like smoking or high blood pressure affect that risk. Abou…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at whether platelet activation in the blood is higher in people whose brain aneurysm has already burst compared to those with an unruptured aneurysm. Researchers will collect blood samples from 230 patients during treatment. The goal is to see if platelet activit…

This study follows 400 people who had a brain aneurysm rupture and were treated with a procedure called embolization. The goal is to learn about their long-term recovery and whether the aneurysm can come back. Researchers will track neurological outcomes using a standard scale. T…

This study looks at how brain aneurysms (specifically intracranial dissecting aneurysms) change over time. Researchers are using high-resolution MRI scans and computer models to find patterns that might predict if an aneurysm will get worse. The goal is to build an AI tool that h…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is a registry that will collect real-world data from 750 people with brain aneurysms treated with MicroVention devices. The goal is to see how well these devices work and how safe they are in everyday medical practice. Participants will be followed for at least one yea…

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study aimed to create a 12-month profile of patients admitted for vascular surgery at University Hospital Limerick in Ireland. The goal was to understand patient characteristics like frailty and other health conditions to improve hospital services and reduce length of stay. …

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…