Bipolar II disorder

This phase 2 trial compares the drug quetiapine with interpersonal and social rhythm therapy (IPSRT) in 216 people with bipolar II disorder who have disrupted daily rhythms. Participants will be randomly assigned to one of the two treatments for 12 weeks. Researchers will measure…

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This pilot study tests whether MyFILM, a 9-week group program using clips from the movie Inside Out, is feasible and acceptable for children aged 9-12 with mood or anxiety concerns. Participants attend weekly sessions to learn social-emotional skills and coping strategies. The st…

This Phase 3 trial tests whether pramipexole, a dopamine-boosting drug, can ease anhedonia (loss of pleasure) in people with bipolar depression. 126 participants will receive either pramipexole or a placebo alongside their usual mood stabilizer for 6 weeks. The study aims to impr…

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can ease depression in people with bipolar II disorder who haven't improved with standard treatments. About 90 adults aged 19-65 will receive either the full dose or a very low placebo dose, and their…

This study tests whether empagliflozin, a drug used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take the drug for 12 weeks alongside their usual treatment. The goal is to see…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study tests an 8-session psychoeducational program called 'Key to Emotional Balance' for adults with bipolar disorder. The program uses positive psychotherapy to help people better regulate their emotions, support recovery, and find more meaning in life. Researchers will com…

This lab study tests whether gold nanoparticles can carry lithium directly to brain cells, potentially reducing side effects. Researchers will use neural cells grown from blood samples of people with bipolar disorder and healthy volunteers, plus a mouse model of mania. The goal i…

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study aims to better understand why young people (ages 18-25) with mood disorders may be at risk for suicide. Researchers will collect clinical, brain imaging, genetic, and microbiome data from 180 participants to identify risk factors. They will also test whether a non-inva…