Bacterial urinary tract infection

This phase 2 trial is investigating how a combination of two antibiotics, cefepime and enmetazobactam, is processed by the body and whether it is safe and tolerable in children from birth to under 18 years old who are hospitalized with a complicated urinary tract infection (cUTI)…

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This study tests a new IV antibiotic (aztreonam-avibactam) in hospitalized children aged 9 months to 18 years with serious gram-negative bacterial infections. About 48 participants will receive either the new drug or the best available standard treatment. The goal is to see how t…

This study tests whether taking a short course of antibiotics (ciprofloxacin) after Botox injections into the bladder can reduce the chance of urinary tract infections. About 160 adults with neurogenic overactive bladder (due to conditions like multiple sclerosis or spinal cord i…

This study provides a fecal transplant product made from healthy donor stool to treat people with recurrent Clostridium difficile infection or multidrug-resistant urinary tract infections. The product is delivered by courier or FedEx after a contract is signed. The goal is to res…

This 6-month study tests whether a daily D-Mannose drink mix (FLUSH) can help women with a history of recurrent UTIs have fewer infections and better urinary health. About 210 adult women will be randomly assigned to one of three groups. Researchers will track how long it takes f…

This study tests whether taking the antibiotic ciprofloxacin for three days after bladder Botox injections reduces the risk of urinary tract infections in women with overactive bladder. About 202 women will be randomly assigned to receive either the antibiotic or a placebo pill. …

This study tests whether taking a daily vitamin C pill for 10 days can prevent catheter-associated urinary tract infections in women having elective gynecologic surgery. Half of the 180 participants will receive vitamin C, and half will receive a placebo. The goal is to see if th…

This study tests a vaginal gel called Multi-Gyn UT Protect to see if it can prevent repeated urinary tract infections (UTIs) in women. Fifty adult women who have had multiple UTIs in the past year but no current infection will apply the gel twice a week for four months. Researche…

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to se…

This study compares two ways to clean the area before placing a temporary bladder catheter: Betadine (the current standard) versus sterile water. Researchers want to see if sterile water leads to fewer bacteria in the urine and less pain during the procedure. About 148 adults who…

This study looks at whether standing in the shower instead of sitting on the toilet helps women urinate more easily after having a catheter removed following vaginal surgery. The goal is to see if this position reduces pain, lowers the amount of urine left in the bladder, and dec…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study looks at how doctors can improve antibiotic prescriptions for urinary tract infections (UTIs) after patients leave the emergency department. Researchers will check if adjusting antibiotics based on lab test results reduces the use of strong drugs like fluoroquinolones.…

This study collects urine samples from adults who use intermittent catheters, both during urinary tract infections (UTIs) and during symptom-free periods. The goal is to explore basic urine characteristics, like bacterial counts, to better understand UTIs in this group. No treatm…

This study follows 400 adults who receive a Double-J ureteral stent—a tube that helps drain urine from the kidney to the bladder. The goal is to identify risk factors for bacteria sticking to the stent and to see how this colonization relates to urinary tract infections, antibiot…

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…