Aortic valve insufficiency

This study tests a new, less invasive way to replace a leaky aortic heart valve (aortic regurgitation) using a device called the JenaValve Trilogy, compared to standard open-heart surgery. About 1,000 people with moderate to severe aortic regurgitation will be randomly assigned t…

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This registry will follow 500 adults with severe aortic stenosis who receive a SAPIEN 3 Ultra Resilia heart valve through a minimally invasive procedure. Researchers will track how well the valve works and how safe it is over 10 years. The goal is to see if this newer valve desig…

This study is testing a new heart valve called the SAPIEN X4 in 200 people whose existing artificial aortic valve is failing. The valve is placed using a thin tube through an artery, avoiding open-heart surgery. The goal is to see if it is safe and effective at improving survival…

This study compares two different devices (Allegra and Sapien) used to replace a failing surgically implanted aortic heart valve without open-heart surgery. About 104 adults with a deteriorated biological aortic valve will be randomly assigned to get one of the two devices. The m…

This study is testing a new device called the J-Valve, which is a replacement heart valve delivered through a tube in the leg, to treat severe aortic regurgitation (a leaky heart valve). The trial will include 194 people with severe symptoms who are at high risk for open-heart su…

This study compares a new, less invasive heart valve implant (TAVR) with standard medication for people who have severe aortic regurgitation, a condition where the heart's aortic valve doesn't close properly. The trial will enroll 210 participants across multiple centers. The goa…

This study looks at whether early surgery to repair or replace the aortic valve is better than waiting until symptoms appear in people with severe aortic regurgitation (a leaky heart valve). About 217 adults with no symptoms but severe valve leakage will be randomly assigned to e…

This study tests a new way to replace the aortic valve in people with severe aortic regurgitation (a leaky heart valve). About 180 patients will get either the new VitaFlow valve or another device through a tube in the leg. The goal is to see if the new valve is safe and effectiv…

This study is testing a device called JenaValve Trilogy to replace the aortic valve without open-heart surgery in 75 people with severe aortic regurgitation (a leaky heart valve). Participants are at high risk for surgery. The main goal is to see if the device works safely and st…

This clinical trial is testing two different surgical methods to repair a bicuspid aortic valve, a common heart defect where the valve has two flaps instead of three. The study will enroll 100 people with this condition who also have a leaky valve (aortic regurgitation). Half wil…

This study tests whether a quick blood test (CT-ADP) can help doctors detect and fix leaks around a new heart valve during a minimally invasive TAVI procedure. Currently, doctors often use general anesthesia and an ultrasound probe in the throat to check for leaks, but this study…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests whether an artificial intelligence (AI) tool can diagnose aortic regurgitation—a leaky heart valve—more accurately than standard manual methods. About 540 adults with confirmed aortic regurgitation will be randomly assigned to either AI-assisted or traditional di…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see which measures heart valve disease more accurately. Researchers will enroll 200 adults with suspected moderate or severe valve problems. The goal is to improve how doctors assess va…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

Researchers are tracking outcomes for 30 people with severe pure aortic regurgitation who receive a transcatheter aortic valve implantation using the JenaValve or J-Valve system. All participants are considered high-risk for open heart surgery. The study uses CT scans at 6 months…

This study is a registry that collects information from routine care to see how well minimally invasive heart valve procedures work over 5 years. It includes adults over 18 who have had a transcatheter aortic valve replacement or similar treatment. No new treatments are given; th…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This study compares two methods—ultrasound (echocardiography) versus direct pressure measurements (catheterization)—to guide additional balloon inflation after valve-in-valve TAVR. About 310 people with failing surgical aortic valves will be randomly assigned to one method. The g…

This observational study is testing whether a noninvasive finger imaging device can detect and evaluate two types of heart valve disease: aortic regurgitation and aortic stenosis. Researchers will record arterial waveforms from participants' fingers and see if the patterns can di…

This study aims to find biological differences between men and women with heart valve disease using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe aortic or mitral valve problems. The goal is to better predict how the heart recovers after valv…

This study is a large registry that will follow 10,000 people who have had a procedure called TAVR to replace a faulty heart valve. The goal is to see how patients do over the long term in everyday medical practice. No new treatment is being tested; instead, researchers are colle…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This observational study will follow 1900 people with moderate mixed aortic valve disease (a combination of aortic stenosis and regurgitation) to see how symptoms and heart function relate to survival and the need for valve replacement. Researchers hope to identify which patients…