Aortic valve atresia

This study looks at whether people with an On-X mechanical aortic heart valve can safely take a lower dose of the blood thinner warfarin. The goal is to reduce bleeding complications while still preventing dangerous blood clots. Researchers will follow 510 adults for up to 5 year…

This trial investigates whether pulsed field ablation (PFA) can safely isolate the pulmonary veins in adults with congenital heart disease who experience atrial tachycardia. Participants will undergo PFA during a standard ablation procedure. The study measures how well the veins …

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study looks at how well the Harmony Transcatheter Pulmonary Valve (TPV) works when used by doctors in everyday practice. It involves 174 people with congenital heart disease who need a new pulmonary valve. The main goal is to see if the valve works properly without needing a…

This early-phase trial tests whether giving stem cells (from a donor) during heart-lung bypass surgery is safe for infants under 6 months with certain congenital heart defects. Seventeen infants will receive the cells while undergoing heart repair. The main goal is to check for s…

This study tests whether propranolol, a drug often used for high blood pressure, can safely treat chylothorax—a buildup of lymphatic fluid—in children after open heart surgery. About 50 children aged 7 days to 18 years with congenital heart disease will receive either propranolol…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study looks at how safe and effective the Avalus Ultra artificial heart valve is for people with aortic valve disease. About 190 participants will be followed for one year after surgery to check for problems like blood clots or valve failure, and to see how well the valve wo…

This study is testing a small mechanical heart valve (15mm) in 20 children who need their aortic valve replaced due to disease or damage. The valve is designed to last and is monitored for safety and function over 5 years. Children will need lifelong blood-thinning medication to …

This study follows 255 Chinese patients who received the INSPIRIS RESILIA aortic valve to see how safe and well it works over several years. Researchers track problems like valve failure, blood clots, bleeding, and the need for another surgery. The goal is to confirm the valve's …

This study tests a new way to manage blood flow and oxygen in children right after heart surgery. The goal is to help their bodies use oxygen better during the critical first 8 hours, which may prevent dangerous drops in blood pressure or heart function. About 300 children weighi…

This study is testing a new type of heart valve called the Harmony TPV, which is placed using a thin tube (catheter) instead of open-heart surgery. It is for people with congenital heart disease who have a leaky pulmonary valve. The study will check if the valve works well and is…

This trial compares two ultrasound-guided nerve blocks—erector spinae plane block and modified pectoral fascial plane block—for pain control in children undergoing congenital heart surgery. Forty children will be randomly assigned to receive one of the blocks before their incisio…

This study follows 50 people who previously received an INSPIRIS RESILIA aortic valve and now need a valve-in-valve procedure because their original valve is not working well. Researchers will track complications like death, stroke, bleeding, and valve movement, as well as how we…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study was designed to see if early mobilization and a simple bottle-based breathing device (Bottle-P.E.P.) could improve breathing and physical function in people recovering from heart valve surgery. The trial was withdrawn before enrolling any participants, so no results ar…

This study at Boston Children's Hospital will test whether measuring thousands of proteins in a few drops of blood can predict which children with congenital heart disease will have serious complications after heart surgery. Researchers will collect blood samples from 60 children…

This study tests a new sensor worn on the skin that measures lactate levels without needles. It involves 20 adults recovering from heart bypass or valve surgery. The goal is to see if the sensor works as well as standard blood tests, which could make monitoring more comfortable a…

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study is collecting DNA and health information from 32,000 people with congenital heart defects. Researchers hope to find genetic causes and understand why outcomes vary. No treatment is being tested—this is a research study to gather knowledge.

This study compares two methods for deciding which blocked heart arteries need bypass during valve surgery. The standard method uses angiography (X-ray dye), while the new method uses a computer calculation called QFR. About 792 patients will be randomly assigned to one method, a…