Tianjin Medical University Cancer Institute And Hospital

This phase II trial tests a combination of four drugs—chidamide, dinutuximab beta, irinotecan, and temozolomide—in 27 children whose neuroblastoma has returned or not responded to standard treatment. The goal is to see how well the regimen controls the cancer and to monitor side …

This phase 3 trial tests whether adding radiotherapy to standard chemotherapy after pancreatic cancer surgery can prevent the cancer from coming back. It enrolls 288 high-risk patients who have had surgery but still have factors like positive margins or lymph node involvement. Pa…

This phase 2 trial is testing a new type of radiation called lattice radiation therapy (LRT) combined with immunotherapy in 30 people with advanced solid tumors that are no longer responding to standard treatments. LRT delivers high doses of radiation to small spots inside the la…

This phase 2 trial tests whether adding two immune-targeting drugs (serplulimab and nimotuzumab) to standard chemoradiation can improve tumor response before surgery in 46 patients with resectable esophageal cancer. Participants receive the combination, then undergo surgery 6-8 w…

This phase II trial is testing whether adding the immunotherapy drug serplulimab to standard chemoradiotherapy can help people with locally advanced cervical cancer live longer without their disease getting worse. About 216 participants who have not yet been treated will receive …

This phase II trial is testing whether a new immune cell treatment called WAST cells, combined with the chemotherapy drug docetaxel, can shrink tumors or slow disease in people with advanced non-small cell lung cancer that has stopped responding to PD-1 inhibitors. The study plan…

This study tests a new combination of three drugs (chidamide, rituximab, and polatuzumab vedotin) in elderly patients with a specific type of untreated lymphoma called double-positive DLBCL. The goal is to see how many patients achieve complete remission after treatment. About 58…

This study tests whether anlotinib hydrochloride capsules can help prevent lung cancer from coming back in patients who still had cancer cells after surgery and chemotherapy. About 64 adults with stage IIA-IIIA non-small cell lung cancer will take the drug daily. The main goal is…

This study looks at two treatment options for people with a type of esophageal cancer that shrank after initial chemo-immunotherapy. One group will have surgery to remove the cancer, while the other will receive stronger chemoradiation instead. The goal is to see if chemoradiatio…

This study tests whether adding an immunotherapy drug (sintilimab) to short-course radiation and chemotherapy can improve long-term survival in people with a common type of locally advanced rectal cancer (MSS type). About 130 adults aged 18-75 with stage II/III rectal cancer will…

This study tests whether a sequence of treatments—chemotherapy infused into the liver, two drugs (durvalumab and bevacizumab), and targeted radiation—can shrink advanced liver cancer enough to allow surgery. About 30 adults with liver cancer that cannot currently be removed will …

This study tests a new treatment for people with stage II to IIIB non-small cell lung cancer who had surgery but still had cancer cells left. The treatment combines a special immune cell therapy (L-TIL) with an immunotherapy drug (tislelizumab) to try to keep the cancer from comi…

This phase II trial is testing a new way to treat lung cancer that has spread to the brain. It combines a targeted cancer pill (osimertinib) with a special type of whole-brain radiation that tries to protect the memory center (hippocampus). The study will enroll 74 people with a …

This study tests a combination of furmonertinib (a targeted pill), chemotherapy injected into the spine, and precise radiation for people with a specific type of lung cancer (EGFR mutation) that has spread to the brain and its lining. The goal is to see if this approach can contr…

This study tests a combination of four drugs (sintilimab, ipilimumab, cetuximab, and dabrafenib) in people with a specific type of advanced colorectal cancer that has a BRAF V600E mutation and is microsatellite stable. These cancers are hard to treat and don't respond well to sta…

This study tests a mix of three drugs (liposomal irinotecan, capecitabine, and enlonstobart) plus a short course of radiation given before surgery for locally advanced rectal cancer. The goal is to see if this approach can make tumors disappear completely or leave no cancer cells…

This study tests a combination of four drugs (two immunotherapies, a blood vessel blocker, and liver-directed chemo) to shrink advanced liver tumors that cannot be removed surgically. The goal is to make enough tumors shrink so that patients can then have surgery to remove the ca…

This study tests two surgical techniques for bile duct cancer that has spread to nearby lymph nodes. One method removes the bile duct completely to take out all affected lymph nodes, while the other leaves the bile duct in place but may leave some lymph tissue behind. The goal is…

This study tests a two-step approach for people with advanced esophageal cancer that cannot be removed by surgery. First, patients receive a combination of immunotherapy and chemotherapy. Then, based on how well the tumor responds, they get either the same drugs plus radiation or…

This study tests whether adding the drug serplulimab to standard chemoradiotherapy after surgery can help prevent cervical cancer from returning in patients with multiple risk factors. About 134 women aged 18-65 with PD-L1 positive cervical cancer will be randomly assigned to rec…

This early-stage trial tests a new cell treatment called GK01, given alone or with chemotherapy, for people with advanced solid tumors like pancreatic or stomach cancer. The main goal is to check safety and how the body handles the treatment. About 15 participants will be enrolle…

This study tests a combination of two drugs (Sacituzumab Tirumotecan and Furmonertinib) in 25 people with advanced non-squamous non-small cell lung cancer that has an EGFR gene mutation and has stopped responding to standard treatments. The goal is to see if the combo can shrink …

This study tests whether adding the immunotherapy drug iparomlimab after standard chemoradiation can help older adults (70+) with inoperable esophageal cancer live longer without the disease getting worse. About 52 participants will receive the drug for one year after chemoradiat…

This study tests a new approach for people with advanced non-small cell lung cancer whose disease has worsened after initial immunotherapy and chemotherapy. Participants will receive a combination of microwave ablation (using heat to destroy tumors), the immunotherapy drug tislel…

This study tests whether giving additional immune therapy after surgery can help prevent head and neck cancer from coming back. It includes 268 adults who already had a good response to initial treatment. The goal is to see if this approach improves survival and is safe.

This study tests a mix of four drugs (iparomlimab, tuvonralimab, chidamide, and chemo) as a first treatment for people with metastatic pancreatic cancer that has spread. The goal is to see if the combination can shrink tumors and help people live longer. About 33 adults who have …

This study tests whether women with certain aggressive breast cancers (triple negative or HER2-positive) can safely avoid breast surgery if their tumors disappear completely after a combination of chemotherapy and radiation. About 200 participants will receive the non-surgical tr…

This study tests whether a medicated nasal spray (dexmedetomidine) can help women feel relaxed and less anxious during breast-conserving surgery for breast cancer. About 394 women will receive either the spray or a placebo before surgery. Researchers will measure sedation levels,…

This study is testing whether a special nurse-led care plan can help people recover better after head and neck cancer surgery. The plan includes extra support from nurses, dietitians, and counselors to reduce complications and improve quality of life. About 80 adults having surge…

This study looks at whether bacteria inside digestive system tumors can help predict how well a patient will respond to chemotherapy before surgery. Researchers will analyze tumor samples from 90 patients with stomach, colon, pancreatic, or esophageal cancer. The goal is to devel…

This study aims to find the best area of lymph nodes to remove during surgery for advanced stomach cancer. Researchers will track where cancer has spread in 400 patients to guide future operations. The goal is to remove only the necessary nodes, reducing side effects while still …

This study looks at how well CDK4/6 inhibitors work in real life for people with a common type of advanced breast cancer (HR+/HER2-). It will follow 245 patients to see how long the treatment controls the cancer and what options work best if the cancer stops responding. The goal …

This study tests a new abdominal pressure device that helps limit breathing movement during radiation therapy for lung cancer. Researchers want to see if it safely reduces tumor motion, making treatment more accurate. About 50 adults with early-stage lung cancer will take part. T…

This study tests a new AI chatbot that gives personalized health information to people with thyroid cancer before and after surgery. Researchers want to see if using the chatbot helps patients feel more ready to go home and recover better compared to standard education. About 150…