The University Of Texas Health Science Center, Houston

This study tests whether taking freeze-dried fecal microbiota capsules (PRIM-DJ2727) can help adults with ulcerative colitis stay in remission and avoid flare-ups. About 58 participants will receive either the capsules or a placebo alongside their usual treatment. The goal is to …

This study tests whether a once-weekly injection of semaglutide can limit weight gain in adults with overweight or obesity who are quitting smoking. About 197 participants will receive the drug or a placebo, and researchers will measure changes in body weight, body composition, a…

This study compares two irrigation systems (GentleWave and EdgePro) for cleaning infected root canals in teeth with dead nerves (pulp necrosis). About 30 adults needing a root canal will join. Researchers will measure how much bacteria is reduced after treatment using advanced DN…

This study tests if a synthetic bone material (BMP/DBM) is more cost-effective and less painful than the standard method of using the patient's own hip bone for grafting. About 40 people with cleft lip and palate will be randomly assigned to one of the two methods. The goal is to…

This study tests a new approach for people with advanced pancreatic cancer that cannot be removed by surgery. It combines a procedure that uses heat to destroy tumor cells (radiofrequency ablation) with an immunotherapy drug (pembrolizumab) and standard chemotherapy. The goal is …

This study tests whether a combination of brain stimulation (rTMS) and a mental exercise called Episodic Future Thinking (imagining positive future events) can help people with methamphetamine use disorder make less impulsive choices and reduce their desire for the drug. Twenty p…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cocaine use. About 75 adults will receive semaglutide along with counseling. Researchers will measure changes in brain responses to cocaine-relat…

This study tests whether giving a common stomach acid drug (pantoprazole) early after severe bleeding from injury can help prevent kidney damage. About 100 adults with hemorrhagic shock will be randomly assigned to receive the drug either early or at the usual time. Researchers w…

This study tests a new way to repair open spine defects (spina bifida) in newborns right after birth. Surgeons will use a patch made from the baby's own umbilical cord to cover the opening in the spine. The goal is to see if this patch helps the wound heal better, reduces fluid l…

This study tests a new diagnostic tool that helps doctors quickly tell whether a respiratory infection is caused by bacteria or a virus. By using this test early, doctors hope to make better treatment decisions, reduce unnecessary antibiotics, and lower healthcare costs. The stud…

This study is testing a new device called ViTrack that measures blood pressure continuously without needing a needle in the artery. About 40 adults having noncardiac surgery will wear the device on their wrist while their blood pressure is also measured the standard invasive way.…

This study aims to find better ways to test for syphilis in pregnant women and their newborns. Researchers will compare two new molecular tests to the current CDC guidelines to see which is more accurate. About 924 participants will be enrolled, including mothers and babies at ri…

This study tests whether rinsing the belly with povidone-iodine (a common antiseptic) during surgery for a burst appendix can prevent painful abscesses and lower healthcare costs. About 346 adults having appendix removal will be randomly assigned to get the rinse or standard care…

This study tests a smartphone app called MY-RIDE designed to help homeless youth reduce substance use and adopt HIV prevention strategies like condom use and PrEP medication. Researchers will enroll 450 participants and track changes over 15 months. The goal is to see if the app …

This study tests if a gentle electrical pulse to a nerve in the leg can help people with recent spinal cord injuries keep better bladder control. Researchers will compare bladder function and quality of life in 120 adults who receive the stimulation versus those who do not. The g…

This study tests a gentle brain stimulation technique called tDCS to see if it can improve anhedonia—the loss of interest or pleasure—in people with bipolar depression. About 45 adults with bipolar disorder and mild depression will receive targeted stimulation to reward-related b…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve negative symptoms (like lack of motivation and social withdrawal) in people with schizophrenia. Twenty participants will receive either real stimulation to a specific brain area or a sham …

This study tests a safe, non-invasive nerve stimulation device used daily at home for 4 weeks in 20 children with neurogenic bladder due to spina bifida. The goal is to see if it helps reduce bladder medication and improve bladder function. Researchers will measure safety, satisf…

This study looks at whether adding a medicine called Ketorolac to standard pain treatment helps children with cleft palate drink more fluids right after surgery. About 74 children having palate repair will be randomly assigned to get either Ketorolac or a placebo. The main goal i…

This study tests if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve depressive symptoms in people with schizophrenia. Researchers will recruit 120 adults aged 18-60 with schizophrenia and related disorders who also…

This study tests a special capsule that vibrates to help people with spinal cord injury who have trouble controlling their bowels. The capsule is swallowed and aims to stimulate bowel movements without the need for manual stimulation or suppositories. The trial will check if the …

This study tests a program called Launching! to help young adults with autism improve daily living skills, social skills, and readiness for adulthood. About 40 participants and their parents will take part. The program focuses on building independence and quality of life, with re…

This pilot study tests whether suvorexant, a sleep medication, can improve sleep quality, reduce stress, and lower drug cravings in people who have recently stopped using stimulants like cocaine or methamphetamine. Twenty adults with stimulant use disorder will receive either suv…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people with schizophrenia spectrum disorder quit smoking. Fifty participants will receive active stimulation using one of two coil types, and researchers will track changes in smoking habits …

This study tests a 4-week program that teaches people in rural areas how to use ear acupressure (a non-needle technique) to manage chronic pain in the back, neck, knees, or other joints. Participants use a smartphone app to learn self-treatment and are compared to a group that on…

This study looks at whether a safe, non-invasive ear stimulator (taVNS) can be used together with arm and hand exercises to help people with incomplete cervical spinal cord injury. The main goal is to see if the approach is safe and practical, with only 12 adults taking part. If …

This study looks at how the brain works in people with PTSD, focusing on overactive threat responses. Researchers will test a non-invasive brain stimulation technique called tACS to see if it can calm these brain patterns and reduce symptoms like anxiety and hypervigilance. The s…

This study looks at whether not using inhaled nitric oxide (iNO) in newborns with congenital diaphragmatic hernia (CDH) is safe and effective. About 600 babies will be enrolled across multiple hospitals. The goal is to see if avoiding iNO reduces the need for life support or deat…

This study looks at whether drinking only clear liquids for 24 hours before anesthesia can reduce leftover stomach contents in patients taking GLP-1 drugs (like Ozempic). It involves 136 people having an upper endoscopy. Researchers will use ultrasound to check stomach volume and…

This study tests whether a semi-structured checklist for anesthesia handoffs during surgery can improve patient outcomes. Researchers will track 4500 adults having non-cardiac surgery to see if the tool reduces complications like heart injury, kidney injury, or pneumonia. The goa…

This study looks at how brain activity changes when people feel pain. Researchers will use brain scans (fMRI, EEG) and mild brain stimulation (tACS, tRNS) to measure these changes. The goal is to better understand pain, not to treat it. 60 healthy adults who are fluent in English…

This study looks at how firearm owners feel about secure gun storage and temporarily storing guns away from home to prevent suicide. Researchers will talk to gun store owners, range owners, and healthcare providers in the Houston area. The goal is to learn what messages work best…

This study tests a cooking and nutrition program for 50 adults in Texas who are recovering from opioid use and taking medication-assisted therapy. Participants will learn cooking skills and healthy eating habits. The goal is to see if the program increases their confidence in coo…

This study is collecting health information from 5,000 people who have a genetic risk for aortic disease (aneurysm or dissection). The goal is to better understand how different gene changes affect the disease and find factors that influence outcomes. No new treatment is being te…

This study aims to understand how the brain works differently in people with PTSD, especially regarding anxiety and hypervigilance. Researchers will use brain scans and EEG to measure brain activity. They will also test a non-invasive brain stimulation technique called tACS to se…

This study looks at donated blood to see if it contains high levels of a protein called pTau217, which is linked to Alzheimer's disease. Researchers want to know if blood transfusions might pass on this risk to recipients. About 250 blood donors will provide samples for testing.

This study looks at how genes influence the body's response to a natural hormone called GLP-1 in Mexican-Americans with prediabetes. Researchers will analyze DNA and gene activity to understand why some people respond differently to GLP-1, which helps lower blood sugar and weight…

This study looks at two methods of monitoring muscle relaxation during surgery: a more precise quantitative monitor and a less expensive qualitative one. The goal is to see which method helps patients breathe better after surgery. Over 1000 adults having general anesthesia with a…

This study is for 1500 people with cluster headache or trigeminal neuralgia. Researchers will collect health information and genetic samples to learn more about these painful conditions. The goal is to better understand what causes them and how they affect daily life.