The University Of Texas Health Science Center, Houston

This study is testing two different humidity levels (70% and 90%) in incubators for extremely premature infants born before 25 weeks. The goal is to see which level helps prevent dehydration and leads to better survival and fewer health problems. About 350 babies will take part i…

This study tests whether a special graft made from donated placental tissue, called ActiveMatrix, can help the shoulder tendon heal better after rotator cuff repair surgery. About 72 people with a full-thickness tear in 1 or 2 tendons will be randomly assigned to get either a low…

This phase II trial tests a new approach for people with advanced pancreatic cancer that cannot be removed by surgery. Participants first receive standard chemotherapy, then an endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to heat and destroy tumor tissue, follow…

This study tests a patch made from a newborn's own umbilical cord to close a spinal defect (spina bifida) within 24 hours of birth. The patch acts as a cover for the spinal cord, aiming to reduce complications like fluid leakage and scarring. Fifteen babies will be enrolled, and …

This study looks at whether giving the acid-reducing drug pantoprazole (Protonix) early after a traumatic injury with severe bleeding can lower the risk of acute kidney injury. Researchers will compare early dosing (within 2 hours of arrival) to usual timing (in the ICU) in 100 a…

This study tests whether a very low dose of semaglutide (a drug used for weight loss and diabetes) can help people with HIV avoid regaining weight after an initial weight-loss period. About 30 adults with HIV who are on stable HIV treatment and are overweight or obese will take p…

This study compares two bone grafting techniques for people with cleft lip and palate. One method uses a lab-made bone material, while the other uses the patient's own hip bone. The goal is to see which approach is more cost-effective, causes less pain, and heals just as well. Ab…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cocaine use. About 75 adults will receive semaglutide along with counseling. Researchers will measure changes in brain responses, cravings, and d…

This study tests a hospital-based program called Houston-HVIP for people aged 16-35 who have been shot in community violence. Participants get a case manager who helps with needs like job training, housing, and mental health support. The goal is to see if this support reduces the…

This study tests if temporarily blocking the blood supply to the uterus and ovaries during minimally invasive fibroid surgery can reduce blood loss. About 120 women with large or numerous fibroids will be randomly assigned to receive the vessel-blocking technique or standard surg…

This study looks at whether using smaller tubes to draw blood can reduce the need for red blood cell transfusions in adult ICU patients with anemia. About 688 participants will be randomly assigned to have blood drawn with either small or standard tubes. The goal is to see if sma…

This study tests if a more precise way to monitor muscle relaxants during surgery can improve breathing after the operation. About 1,000 adults having non-heart surgery will be randomly assigned to either the new quantitative monitor or the standard qualitative one. The goal is t…

This study compares two irrigation systems, GentleWave and EdgePro, for cleaning infected root canals in adults with dead nerves (pulp necrosis). About 30 participants will have their bacterial levels measured before and after treatment. The goal is to see which system reduces ba…

This early-stage study tests nicotinamide riboside (NR), a form of vitamin B3, in 15 people with smooth muscle dysfunction syndrome (SMDS) — a rare genetic condition that can cause moyamoya-like narrowing of brain arteries. Researchers want to see if NR improves blood flow to the…

This study tests whether taking freeze-dried fecal transplant capsules (PRIM-DJ2727) can help adults with ulcerative colitis stay in remission and avoid flare-ups. About 58 participants will take the capsules or a placebo for 12 weeks alongside their usual treatment. The goal is …

This study tests a community program called Young HEROES for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. The goal is to see if this approach works better than usual care in …

This study compares two different fat emulsions given intravenously to extremely preterm infants (born before 28 weeks or weighing ≤1000g). The goal is to see which type better prevents bronchopulmonary dysplasia (a chronic lung disease) and supports normal brain development at a…

This study tests a device that stimulates a nerve in the leg to help people with spinal cord injury manage their bladder function at home. About 21 adults with chronic spinal cord injury (at level T9 or above) will use the device and be monitored for safety, reliability, and ease…

This study tests a new device called ViTrack that measures blood pressure continuously without needles. It will be used on 40 adults having surgery who already need standard invasive blood pressure monitoring. The goal is to see if the device matches the accuracy of the current m…

This study aims to increase syphilis testing and treatment for pregnant women who haven't had prenatal care or a syphilis test during their pregnancy. Researchers will offer rapid point-of-care tests in the emergency department and obstetrical triage, then help connect those who …

This study is testing a new diagnostic tool that helps doctors quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if using this test leads to better treatment decisions, fewer unnecessary antibiotics, and lower healthcare costs. About 100…

This study aims to find better ways to test for syphilis in pregnant women and their newborns. Researchers will compare new molecular tests to current CDC guidelines to see which is more accurate. About 924 participants will be enrolled, including mothers and babies at risk. The …

This study tests whether five weekly video therapy sessions led by trained non-professional counselors can prevent depression in older, low-income stroke survivors who have mild depressive symptoms. Researchers will track 350 participants for up to three months to see if the prog…

This study tests a smartphone app called MY-RIDE that offers just-in-time support and nurse-led sessions to help homeless youth reduce substance use and adopt HIV prevention methods like PrEP. 450 participants aged 15-24 who are homeless, use substances, and are sexually active w…

This study tests whether rinsing the abdomen with povidone-iodine (a common antiseptic) during surgery for a burst appendix can prevent painful internal abscesses. About 346 people having appendix removal will be randomly assigned to get the iodine wash or standard care. Research…

This study works with health clinics to find better ways for doctors to recommend the HPV vaccine to Latino adolescents. The goal is to increase the number of teens who get the vaccine on time. Researchers will test different support strategies across nine clinics and track vacci…

This early study tests a device called BreEStim that uses breathing to control mild electrical stimulation on the arm. The goal is to reduce finger stiffness and improve hand function in people who had a stroke at least 6 months ago and have severe hand impairment. Only 4 partici…

This study tests a 12-week program called Launching! to Adulthood for young adults with autism. Participants attend weekly group sessions and get individual coaching to improve daily living skills, social abilities, and readiness for adulthood. The study compares them to a group …

This study tests a small, home-use device that sends mild electrical pulses to a nerve in the leg (tTNS) to improve bladder control in 20 children with spina bifida who have neurogenic bladder. Half the kids will use the real device, half a sham device, for 30 minutes daily, 5 da…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) is safe and practical when used during arm and hand rehabilitation exercises. Twelve adults with chronic incomplete cervical spinal cord injury will receive 18 therapy sessions over six weeks, fol…

This study is testing whether a non-invasive brain stimulation technique called TMS can help reduce depressive symptoms in people with schizophrenia. Researchers will treat 120 adults aged 18-60 who have both schizophrenia and depression. The goal is to see if TMS improves mood a…

This study tests an 8-week social engagement program for seniors who have recently left Adult Protective Services after experiencing elder abuse or self-neglect. The program pairs each senior with a trained student volunteer who makes weekly calls to reduce loneliness and depress…

This early study tests a device that uses your own breathing to trigger mild electrical stimulation, aiming to reduce hand stiffness and improve hand movement in people who had a stroke at least 6 months ago. Only 4 participants with moderate hand tightness will be enrolled. The …

This study tests a 4-week program that teaches people in rural areas to use ear acupressure (a non-needle technique) to manage chronic musculoskeletal pain like back, neck, or knee pain. Participants use a smartphone app to learn self-treatment, with some receiving in-person trai…

This study tests if a non-invasive brain stimulation technique called rTMS can improve negative symptoms (like lack of motivation or emotion) in people with schizophrenia. About 20 adults will receive either real or sham stimulation to different brain areas. The main goal is to s…

This pilot study tests a new approach called BreEStim, which uses breathing to control mild electrical stimulation, to help reduce hand stiffness and improve hand function in people who had a stroke at least 6 months ago. Only 4 participants with moderate hand tightness will be e…

This study tests a gentle electrical brain stimulation called tACS to see if it can reduce nerve pain in people with spinal cord injury. Researchers will measure pain levels and heart rate changes in 14 adults. The goal is to find a new, drug-free way to manage chronic pain.

This study is testing whether a gentle brain stimulation device (tDCS) used at home is safe and acceptable for people with early-to-moderate Huntington's disease. Ten participants will use the device daily for several weeks while researchers track side effects, mood, thinking ski…

This study tests if a mild electrical stimulation on the leg (called TTNS) can help people with recent spinal cord injuries maintain bladder function. Researchers will measure bladder capacity and sensation in 120 adults admitted to rehab within 6 weeks of injury. The goal is to …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study tests a gentle, non-invasive brain stimulation technique called tACS to see if it can improve hand and arm movement in people who have had a stroke. Researchers will enroll 14 adults who are at least 6 months past their stroke and have some finger movement. The goal is…

This study tests a gentle brain stimulation technique called tDCS to see if it can improve anhedonia—the loss of interest or pleasure—in people with bipolar depression. About 45 adults with bipolar disorder and significant anhedonia will receive tDCS while researchers use brain s…

This study tests whether a 2-week, fully remote program combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms. About 146 adults with both conditions will receive either real or sham stimulation alongside therapy, all fro…

This early study tests whether combining a non-invasive brain stimulation technique (rTMS) with a mental exercise called Episodic Future Thinking (imagining positive future events) can help people with methamphetamine use disorder make less impulsive choices and reduce their desi…

This study tests if a once-weekly injection of semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive the drug or a placebo, and researchers will track changes in body weight, body fat, and appetite…

This study tests whether a sleep medication called suvorexant can improve sleep, reduce stress, and lower drug cravings in people who have recently stopped using stimulants like cocaine or methamphetamine. Twenty adults with stimulant use disorder will receive either the drug or …

This study tests whether a special vibrating capsule is safe and helpful for people with spinal cord injury who have trouble controlling their bowels. About 12 adults with chronic spinal cord injury will try the capsule as part of their regular bowel routine. The goal is to see i…

This study tests whether adding a pain medicine called Ketorolac to standard care helps children drink more fluids after cleft palate surgery. About 74 children with cleft palate (with or without cleft lip) will take part. The goal is to see if better pain control leads to improv…

This study tests whether a single dose of an IV medication can prevent labor from stalling and reduce the need for C-sections in first-time mothers. Researchers will enroll 200 women in active labor with cervical swelling. The goal is to see if the drug helps the cervix fully dil…

This study is creating a large registry of extremely premature infants born at 22-23 weeks of pregnancy. Researchers will collect information on the care these babies receive and their outcomes. The goal is to learn what practices work best for this vulnerable group. No new treat…

This study looks at donated blood samples to see if some contain high levels of a protein called pTau217, which is linked to Alzheimer's disease. Researchers want to know if blood with elevated pTau217 could be risky for transfusion recipients. The study involves 250 blood donors…

This study looks at how genetic differences in Mexican-Americans with prediabetes affect their response to semaglutide (Ozempic), a GLP-1 drug. Researchers will measure changes in insulin production, blood sugar, and gene activity in 300 participants. The goal is to find genetic …

This study looks at how a non-invasive brain stimulation technique called TMS affects the brain's fear circuits. Researchers will test different TMS settings in 250 people with and without PTSD to see how it changes fear-related brain activity and skin responses. The goal is to l…

This study is building a large database of health information from 2000 people with multiple sclerosis (MS). Researchers will use electronic health records and patient surveys to track disability and thinking problems over time. The goal is to find better ways to improve MS care …

This study tests whether non-invasive sensors can detect reduced blood flow in the legs during long pelvic surgeries. Thirty adults will be monitored during their procedure. The goal is to see if this approach can help prevent complications like limb ischemia.

This study tests whether a new team-based approach can help primary care doctors diagnose anemia and decreased kidney function more accurately and quickly. The approach includes automated tracking of abnormal test results, adding care partners to guide follow-up, and using nurse …

This study is creating a large collection of health information and tissue samples from up to 15,000 neurosurgery patients. The goal is to provide researchers with the data they need to better understand neurological conditions and develop new treatments. Participants provide blo…

This study looks at how the brain works in people with PTSD, focusing on areas that control alertness and fear. Researchers will use a gentle brain stimulation technique called tACS to see if it can improve brain activity and reduce anxiety. About 160 adults aged 18 to 50 with PT…

This study looks at how people with PTSD learn to avoid certain situations. Researchers will use brain scans and skin sensors to measure fear and stress responses during learning tasks. The goal is to understand the brain processes behind avoidance, not to test a treatment. About…

This study looks at how the brain works in people with PTSD, focusing on why they feel constantly on edge. Researchers will test a gentle brain stimulation technique called tACS to see if it can calm overactive brain circuits and reduce anxiety. The study involves 160 adults aged…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is gathering 5,000 people with certain gene changes that raise the risk of aortic disease (like aneurysms or dissections). Researchers will track their health over time to see how these genes affect the condition. The goal is to better predict and manage the disease, n…

This study looks at whether not using inhaled nitric oxide (iNO) in newborns with congenital diaphragmatic hernia (CDH) leads to better outcomes, like fewer needing life support or dying. About 600 babies from multiple hospitals will be included. The goal is to see if stopping th…

This study looks at whether drinking only clear liquids for 24 hours before anesthesia can reduce stomach contents in patients taking GLP-1 receptor agonists (like Ozempic). The goal is to lower the risk of stomach contents entering the lungs during surgery. About 136 adults on t…

This study is gathering information from 1,500 people with cluster headache or trigeminal neuralgia to learn more about these painful conditions. Researchers will collect surveys, genetic samples, and other health data. The goal is to better understand what causes these headaches…

This study looks at how brain connections change when people feel pain. Researchers will use brain scans (fMRI, EEG) and mild brain stimulation (tACS, tRNS) to measure these changes. The goal is to better understand pain, not to treat it. The study needs 60 adults who are fluent …

This study is creating a registry and biorepository for people who have had a suspected amniotic fluid embolism (AFE), a rare and serious pregnancy complication. Researchers will collect medical information and biological samples from up to 400 participants, including mothers, th…

This study is creating a registry of children and teens with bipolar disorder, their siblings, and healthy volunteers. Researchers will collect blood and saliva samples, do brain scans, and track symptoms over time to better understand the condition and find early warning signs. …