Peking University Cancer Hospital & Institute

This study tests an experimental drug called SHR-A1811 in 51 women with HER2-positive breast cancer that has spread to the brain. It aims to see if the drug is safe and can shrink or control brain tumors, including cases where cancer has reached the lining of the brain. Participa…

This study tests a new immunotherapy drug called iparomlimab tolvorlimab (QL1706) given before surgery to people with a specific type of advanced stomach cancer (MSI-H/dMMR). The goal is to see if the drug can shrink or eliminate the tumor, making surgery more effective. About 30…

This study looks at whether adding pyrotinib to two standard drugs (trastuzumab and pertuzumab) can help keep advanced HER2-positive breast cancer from growing. About 42 adults with this type of cancer will receive the combination as maintenance therapy after initial treatment. T…

This study tests a standardized treatment plan for esophageal fistula, a severe complication in advanced esophageal cancer that can cause life-threatening infections and malnutrition. The plan includes sealing the fistula with stents, targeted antibiotics, nutritional support, an…

This study tests whether a combination of two drugs (vorolanib and everolimus) works better than the standard drug sunitinib for people with advanced kidney cancer that has worsened after immunotherapy. About 116 adults aged 18-80 with clear cell kidney cancer will be randomly as…

This study tests whether starting abemaciclib at a lower dose and gradually increasing it can help patients with early high-risk HR+/HER2- breast cancer tolerate the drug better. The goal is to reduce side effects like diarrhea and fatigue, so more patients can complete their ful…

This study compares a new drug, SHR-A1811, with a standard combination therapy (pyrotinib plus capecitabine) in 100 adults with advanced HER2-positive breast cancer that did not respond to the first-line drug trastuzumab. The goal is to see which treatment better delays cancer gr…

This study tests whether a short course of radiation, while keeping certain lymph nodes intact, followed by an immunotherapy drug (PD-1 inhibitor) can completely eliminate rectal cancer before surgery. It involves 44 adults with stage II-III rectal cancer. The goal is to see if t…

This study tests whether adding the drug adebrelimab (a type of immunotherapy) as maintenance therapy after standard chemotherapy and radiation can help control limited-stage small cell lung cancer. About 76 adults aged 18-75 with untreated, localized disease will be enrolled. Th…

This study tests whether giving a high dose of the targeted drug firmonertinib together with bevacizumab before surgery can improve outcomes for people with a specific type of lung cancer (EGFR-mutated, stage II-IIIB). About 62 participants will receive the drug combination, then…

This study is for people with limited-stage small cell lung cancer whose disease is under control after chemoradiation. Researchers will use a blood test (MRD) to find patients with leftover cancer cells. Those patients will then receive a combination of immunotherapy and anti-an…

This study tests a drug called ivonescimab, given alone or with chemotherapy, before and after surgery for people with a certain type of lung cancer (non-small cell lung cancer) that can be removed. The goal is to see if this approach can shrink tumors before surgery and prevent …

This study tests a robotic system that helps doctors mark small lung nodules with a dye before surgery. The goal is to make it easier for surgeons to find and remove these nodules during a minimally invasive procedure. About 50 adults with small, hard-to-locate lung nodules will …

This study tests whether a higher dose (160 mg) of the drug firmonertinib can improve outcomes for people with advanced EGFR-mutant non-small cell lung cancer whose tumors have stayed stable but not shrunk after 8 weeks on the standard 80 mg dose. About 28 adults aged 18-75 with …

This study tests a new drug called adebrelimab, given together with standard chemotherapy and radiation, for people with limited-stage small-cell lung cancer. The goal is to see if this combination helps control the disease longer and is safe. About 30 adults aged 18-75 will take…

This study tests whether using a special PET scan (HER2-PET/CT) can help doctors personalize chemotherapy for early-stage HER2-positive breast cancer. After two cycles of treatment, the scan shows how well the tumor responds, allowing some patients to get stronger treatment and o…

This study tests whether adding a new drug (recaticimab) to standard immunotherapy and chemotherapy before surgery can improve outcomes for people with resectable non-small cell lung cancer. About 78 adults with stage II to IIIB cancer will receive the combination, then have surg…

This study tests whether adding radiation and two immunotherapy drugs to standard chemotherapy can help people with a specific type of advanced rectal cancer (RAS-mutant, MSS) live longer without the disease getting worse. About 106 adults aged 18-75 will be randomly assigned to …

This study tests whether using a patient's own gut bacteria (autologous probiotics) can reduce severe bowel problems after temporary ileostomy reversal in rectal cancer survivors. About 40 adults who had rectal cancer surgery with a temporary ileostomy will receive their own cult…

This study tests whether a newer type of PET/MRI scan (using a tracer called FAPI) is better than the standard scan (using FDG) at finding cancer that has spread to lymph nodes in people with middle to high rectal cancer. About 30 patients who have not yet been treated will get b…

This study tests a special PET scan that uses a radioactive probe to detect PD-L1, a protein on tumor cells, in people with lung cancer, melanoma, or other solid tumors. The goal is to see if this scan can predict who will benefit from immunotherapy. About 40 adults aged 18-75 wh…

This study tests a new PET imaging tracer called 68Ga-MY that targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will receive the tracer and undergo PET/CT scans. The goal is to see if this new method finds t…

This study tests whether a traditional Chinese medicine hand and foot bath can reduce nerve pain and numbness caused by taxane chemotherapy in breast cancer patients. About 78 participants will either receive the herbal bath or a standard vitamin B12-like medication. The goal is …

This study follows 255 people with esophageal cancer to see how the disease changes over time. Researchers use blood tests, scans, and tissue samples to find patterns that might predict if treatment is working or if cancer returns. The goal is to improve how doctors personalize c…