Medical University Of Vienna

This study is testing whether a drug-coated balloon can replace the usual stent in emergency heart attack treatment. The balloon delivers medication to open blocked arteries without leaving a permanent implant. Researchers will track 300 patients to see if this approach is safe a…

This study tests whether using a patient's own tumor cells to screen drugs can lead to more effective, personalized treatment for glioblastoma, a severe brain cancer. About 240 adults with newly diagnosed glioblastoma will either receive standard care or standard care plus a pers…

This study tests a drug called datopotamab-deruxtecan in 20 people with triple-negative breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors. Participants must have newly diagnosed or growing brain metastases. The study is currently r…

This study tests a toric add-on lens placed behind the eye's iris to correct high astigmatism (blurry vision) in people who have had a cornea transplant and cataract surgery. About 40 adults aged 45-90 will receive the lens and be followed for up to 7 months to see if their visio…

This study tests a combination of low-dose chemotherapy and targeted drugs to slow tumor growth in children whose brain cancers have returned. The goal is to extend survival while maintaining a good quality of life. About 232 children with recurrent medulloblastoma, ependymoma, A…

This study tests a new drug called BT200 in 4-6 adults with type 2B von Willebrand disease who have low platelets and a history of bleeding. The drug aims to raise levels of a key clotting protein and platelets, which should reduce bleeding episodes. Participants receive both BT2…

This study looks at whether giving an extra balloon inflation after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will be randomly assigned to receive this extra step or not. The goal is to see if i…

This study compares two types of stents used to repair bulges in the main artery (aortic aneurysms). About 126 adults will be randomly assigned to receive either the BeFlared or the VBX stent during a minimally invasive procedure. The goal is to see which device takes less time t…

This study tests a new way to prevent permanent low parathyroid hormone after thyroid surgery. Surgeons will inject mashed parathyroid tissue into the forearm muscle of 100 adults during their thyroid operation. The goal is to see if this simple injection can produce enough hormo…

This study checks whether standard devices that measure blood flow and fluid needs work correctly in patients on ECMO, a machine that pumps and oxygenates blood outside the body. About 30 adults with severe lung failure will be enrolled. The goal is to improve how doctors manage …

This study checks how well standard ICU monitors measure blood flow and fluid needs in 30 adults on VA-ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three monitoring methods to see which works best during this special situation. The go…

This study looks at whether playing music that patients choose themselves during the start and end of anesthesia can lower anxiety and improve comfort. About 100 adults having eye surgery will be randomly assigned to either hear music or not. Researchers will measure anxiety leve…

This study tests whether taking a daily lactobacillus (a type of probiotic) supplement can reduce symptoms of overactive bladder in women. Overactive bladder causes sudden, frequent urges to urinate and affects many older women. The trial will compare the supplement to a placebo …

This study tests a new treatment called transcranial pulse stimulation (TPS) for people with Post-COVID syndrome who suffer from fatigue, memory problems, or low mood. About 102 adults who had COVID-19 at least a year ago will get either real TPS or a sham treatment. The goal is …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can improve the ability to feel pleasure (anhedonia) in people with major depression. 85 participants, including healthy volunteers, will take psilocybin in two sessions—once with a drug that blocks th…

This study tests whether a small device that gently stimulates a nerve in the ear can help people with long-term back pain when used along with standard rehab. About 48 adults with chronic back pain will either get the ear stimulation plus rehab or rehab alone for 3 weeks. The go…

This study compares several types of approved artificial lenses (intraocular lenses) used in cataract surgery to see which one gives the best vision at intermediate distances, like looking at a computer screen. About 461 people aged 50 to 100 with age-related cataracts will recei…

This small pilot study is testing whether low-dose radiation can reduce pain from arthritis of the jaw joint (TMJ). Ten adults over age 50 with TMJ arthritis will receive radiotherapy and report their pain levels and jaw function. The goal is to see if the treatment is safe and p…

This study tests if a 6-week outpatient pulmonary rehabilitation program can improve breathing and walking ability in people with post-PE syndrome, a condition where symptoms like shortness of breath persist after a pulmonary embolism. About 48 adults will be randomly assigned to…

This study looks at whether a new cyclosporin eye drop (Vevizye®) can reduce inflammation and dryness in people with moderate to severe dry eye disease who still have symptoms after using artificial tears. About 25 adults with chronic dry eye and visible eye redness will use the …

This study looks at whether simple, non-invasive brain monitoring tools can give doctors early clues about recovery in patients who need emergency life support after a cardiac arrest. Researchers will use a pupil light reflex device and a brain oxygen sensor before starting ECMO,…

This study involves 20 adults with hypertrophic obstructive cardiomyopathy (HOCM) who are already on standard medications. Researchers want to see if changes in heart blood flow over one year are linked to how far patients can walk in six minutes. Participants will have two heart…

This study observes 1,300 critically ill ICU patients to see if measuring anti-factor Xa activity (a blood thinner level) is linked to dangerous blood clots. Researchers want to understand how well current blood thinner dosing works and whether it affects bleeding, survival, and …

This study aims to find biological markers that can predict whether electroconvulsive therapy (ECT) will work for people with severe depression. Researchers will use brain scans, blood tests, and spinal fluid samples from 30 patients before and after ECT. The goal is to better un…

This study follows transgender men and women who have been on gender-affirming hormone therapy for two years to see how it affects their heart, liver, and pancreas over the next decade. Researchers will use MRI scans, blood tests, and questionnaires to track changes in heart func…

This study is creating a registry and optional biobank for 500 adults with primary biliary cholangitis (PBC) in Austria. Researchers will collect medical data and blood samples during regular clinic visits to track how the disease progresses, including complications like liver ci…

This study follows 10,000 people with advanced chronic liver disease to see how their condition changes over time. Researchers collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. The goal is to learn more about the …

This study tests whether using a video laryngoscope helps doctors place a breathing tube through the nose more successfully on the first try compared to a standard direct laryngoscope. It includes 180 infants under 1 year old with congenital heart disease who need surgery. The go…

This study is looking for ways to predict postoperative delirium—a state of confusion that can happen after surgery—in patients aged 65 and older. Researchers will measure certain substances in the blood before and after surgery to see if they can identify who is at risk. The goa…

This study looks at how gender-affirming hormone therapy changes heart function, fat levels in the liver and heart, and insulin sensitivity. Researchers will follow 40 transgender adults (20 male-to-female, 20 female-to-male) for 6 months using MRI scans and glucose tests. The go…

This study looks at how a custom-made dental expander affects the bones and soft tissues of the face. About 38 people with a narrow upper jaw and crossbite will receive the device, which is anchored to small temporary screws. Researchers will use 3D scans to measure changes befor…

This study looks at whether using a tablet for video interpreting helps emergency doctors talk to patients who don't speak the same language. About 50 awake adults with language barriers will take part. Doctors will rate how easy and useful the video interpreting is, and whether …

This study observes how different hospitals help intensive care unit (ICU) patients start moving early. The goal is to see which types of movement (like sitting up or walking) lead to better physical function and quality of life. Researchers will follow 6,000 adults from around t…

This study follows 5,000 adults who spent more than 72 hours in the ICU to understand long-term problems with thinking, physical health, and emotions. Researchers will collect data during the hospital stay and for up to five years after discharge. The goal is to identify risk fac…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain better an…

This study looks at whether performing chest compressions makes it harder for medical workers to recall a patient's medical history. Thirty-eight trained professionals will do CPR while listening to a patient story, then answer questions. The goal is to understand how multitaskin…

This study looks at how certain diabetes medications (semaglutide, liraglutide, tirzepatide) change blood flow and oxygen use in the eyes of people with diabetes. About 20 adults with diabetes will have their eye blood flow and oxygen levels measured before and after starting one…

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in healthy adults aged 18 to 80 using non-invasive eye scans. Participants will also breathe pure oxygen to see short-term effects. The goal is to understa…