Leiden University Medical Center

This study tests whether giving blood thinners based on each person's risk level after hip or knee replacement works better than the standard one-dose-for-all approach. About 10,000 adults having elective hip or knee replacement will be assigned to either standard care or a perso…

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This study tests whether repeated steroid injections near a nerve in the neck can prevent cluster headache attacks in people with chronic cluster headache. About 50 adults with frequent, one-sided attacks will receive either the real injection or a placebo. The goal is to see if …

This study is testing a new imaging device called Laser Speckle Contrast Imaging (LSCI) to monitor blood flow in the leg before, during, and after surgery to restore circulation. Researchers will enroll 30 people scheduled for leg revascularization. The goal is to see if LSCI is …

This study compares two ways of handling nerves during leg amputation to prevent long-term pain. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to either standard nerve cutting or targeted muscle reinnervation (TMR), where cut nerve…

This study tests whether aerobic exercise or cognitive behavioral therapy can reduce fatigue in people with myasthenia gravis (MG). About 60 adults with stable MG will be randomly assigned to one of three groups: exercise, therapy, or usual care. The goal is to see if these appro…

This study looks at two types of nerve surgery to treat stubborn pain after amputation (phantom limb pain and stump pain). About 98 adults who have had pain for at least 6 months and haven't had prior pain surgery will be followed for 2 years. The goal is to see if either surgery…

This observational study will follow 1900 patients with moderate mixed aortic valve disease (a combination of aortic stenosis and regurgitation) to see how symptoms and heart function affect survival and the need for valve replacement. Researchers hope to identify which patients …

This study looks at why older adults, especially frail ones, lose important immune cells (T cells) from their noses. Researchers will compare young adults, healthy older adults, and frail older adults to understand how this loss happens and if it leads to more respiratory infecti…

This study tests a new online tool that gives patients taking five or more medications personalized information about drug interactions and genetic risks. 120 adults from four European countries will use the tool for 12 weeks and answer questionnaires about their understanding an…

This study is collecting data from 1500 people with liver tumors who are getting a treatment called thermal ablation, which uses heat to destroy cancer. Researchers will use artificial intelligence to analyze this data to find better ways to choose patients, plan the treatment, a…

This study tests a smart technology box for people who have been in the ICU. The goal is to see if it's possible for 50 patients to use the box at home for 12 months to monitor their health and catch problems early. The box is not a treatment, but a way to gather information to i…

This study is a registry that collects information from 400 adults with congenital heart disease who are taking a class of drugs called SGLT2 inhibitors. Researchers want to understand how these drugs are prescribed, how safe and tolerable they are, and whether they help with hea…

This study will use smartphone recordings to measure key symptoms of myasthenia gravis, such as slurred speech, voice changes, arm fatigue, and droopy eyelids. Researchers will compare 225 people with and without MG to see if phone data can help track the disease. The goal is to …

This study checks if a simple finger-prick blood test (dried blood spot) can accurately measure levels of certain cancer drugs, compared to standard blood draws. About 360 adults taking one of 14 cancer medications will provide samples in the clinic and at home. The goal is to se…

This study aims to find immune markers in the blood of 300 women with ovarian cancer that could help predict how well they will respond to treatment. Researchers will analyze blood samples before treatment starts and track patients' health over time. The goal is to better underst…

This study watches 60 ICU patients on breathing machines to see if a new device (SERA) can measure breathing effort and oxygen use. The goal is to find better ways to predict who can safely breathe without the machine. Participants are already getting a standard breathing test, a…