Leiden University Medical Center

This phase 2 trial tests whether a sleep-deepening drug (lower-sodium oxybate) and/or a nerve-stimulating device (non-invasive vagus nerve stimulation) can help the brain clear harmful amyloid proteins in people with cerebral amyloid angiopathy (CAA). Sixty participants will rece…

This study tests a new way of caring for 'hotspotters'—patients with multiple health and social problems who frequently use emergency care. The approach brings together a doctor, mental health nurse, social worker, and the patient to create a personalized care plan with ongoing s…

This study tests whether using a person's individual risk of another blood clot or major bleeding can help doctors decide how long they should take blood thinners after a first clot. About 600 adults who had a first deep vein thrombosis or pulmonary embolism will fill out a quest…

This study tests whether taking mifepristone 50 mg once a week can safely prevent pregnancy. 615 women aged 18-35 will use it as their only birth control for one year. The goal is to see if it works well with fewer side effects than daily hormone pills.

This study tests a combination of two immunotherapy drugs (ipilimumab and nivolumab) plus a chemotherapy drug (melphalan) given directly to the liver for people with advanced uveal melanoma that has spread, especially to the liver. The goal is to see if this approach is safe and …

This study looks at whether bacteria from the throat, stool, and lungs can help predict which patients with stage III lung cancer will have their cancer return during immunotherapy (durvalumab) after chemoradiation. Researchers will also check how antibiotics affect treatment sid…

This study uses special MRI scans to track changes in blood vessel function in the brains of 120 people with early Alzheimer's or mild memory problems, as well as healthy volunteers. The goal is to understand how small blood vessel disease, like cerebral amyloid angiopathy, contr…

This observational study looks at how brain inflammation contributes to frontotemporal lobar degeneration (FTLD), a group of rare brain disorders. Researchers will use advanced MRI scans, blood tests, and spinal fluid samples from 110 participants to track changes over time. The …

This study looks at whether a personalized risk assessment tool called PERSARC can help patients with soft-tissue sarcoma understand their treatment options better and feel less conflicted about their decisions. About 120 adults with high-grade sarcoma in their arms or legs will …

This study follows 500 adults with uveal melanoma (a rare eye cancer) to measure how diagnosis and treatment affect their quality of life, mental health, and decision-making. Participants complete surveys before treatment and for five years after. The goal is to better understand…