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New hope for amputees: nerve surgery may ease phantom limb pain

NCT ID NCT07605754

Symptom relief Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two types of nerve surgery to treat stubborn pain after amputation (phantom limb pain and stump pain). About 98 adults who have had pain for at least 6 months and haven't had prior pain surgery will be followed for 2 years. The goal is to see if either surgery reduces pain and improves quality of life. Participants fill out short questionnaires about pain and daily function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 98 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with intractable postamputation pain after a major extremity amputation (trans humeral, elbow disarticulation, forearm, transfemoral, knee disarticulation, and transtibial) undergoing surgical postamputation pain treatment in our center.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age older than or equal to 18 years * Intractable postamputation pain Exclusion Criteria: * Cognitive impairment or delirium at the time of inclusion * Having received previous radiotherapy on the affected limb * Patients who are unable to comprehend the informed consent form or the questionnaires used in the current study * Unfit for general anesthesia

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Conditions

The condition(s) this trial relates to.

neuroma Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation neuroma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Leiden University Medical Center

    RECRUITING

    Leiden, South Holland, 2333 ZA, Netherlands

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