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New surgery eases phantom limb pain by giving nerves a muscle home

NCT ID NCT07285486

Symptom relief Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a surgical technique called Regenerative Peripheral Nerve Interface (RPNI) in 132 leg amputees to prevent or treat painful neuromas—nerve ends that form painful growths after amputation. The procedure involves implanting the cut nerve into a small piece of muscle to give it a target, reducing the chance of neuroma formation. Researchers measured pain, medication use, and quality of life using patient surveys.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

132 people

The number who actually took part.

Started

Jun 2017

Finished

Jun 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants were recruited from plastic surgery, orthopedic surgery, and vascular surgery clinics.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Major lower limb amputation (chronic pain treatment group only) * Symptomatic residual limb neuroma (chronic pain treatment group only) * Undergoing a major lower limb amputation (prophylactic pain treatment group only) Exclusion Criteria: * History of chronic amputation-related pain (prophylactic pain treatment group only) * History of regenerative peripheral nerve interface (RPNI)

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Conditions

The condition(s) this trial relates to.

neuroma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation neuroma

Contacts and locations

Locations

  • Department of Veterans Affairs Ann Arbor Health System

    Ann Arbor, Michigan, 48105, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.