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New surgery eases phantom pain for amputees

NCT ID NCT07285486

First seen Jan 04, 2026 · Last updated May 23, 2026 · Updated 17 times

Summary

This study tested a surgery called Regenerative Peripheral Nerve Interface (RPNI) to prevent or treat painful nerve growths (neuromas) in people with major leg amputations. The procedure involves placing the cut nerve end into a small piece of muscle to give the nerve a healthy target, reducing the chance of a painful neuroma forming. Researchers followed 132 participants and used surveys to measure pain, medication use, and daily function. The goal was to see if RPNI improves quality of life for amputees.

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Contacts and locations

Locations

  • Department of Veterans Affairs Ann Arbor Health System

    Ann Arbor, Michigan, 48105, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

Conditions

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