Nerve rerouting during amputation may stop phantom pain
NCT ID NCT06719245
First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 42 times
Summary
This study compares two ways of handling nerves during leg amputation to prevent long-term pain. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to either standard nerve cutting or targeted muscle reinnervation (TMR), where cut nerves are rerouted to small muscle branches. Participants will report their pain levels and quality of life over one year to see which method works better.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SURGERY are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Alrijne Zorggroep
NOT_YET_RECRUITINGLeiderdorp, South Holland, 2353 GA, Netherlands
-
Amsterdam University Medical Center
NOT_YET_RECRUITINGAmsterdam, North Holland, 1105 AZ, Netherlands
-
Erasmus Medical Center
NOT_YET_RECRUITINGRotterdam, South Holland, 3015 GD, Netherlands
-
Haaglanden Medisch Centrum
NOT_YET_RECRUITINGThe Hague, South Holland, 2512 VA, Netherlands
-
Isala Zwolle
NOT_YET_RECRUITINGZwolle, Overijssel, 8025 AB, Netherlands
-
Leiden University Medical Center
RECRUITINGLeiden, South Holland, 2333 ZA, Netherlands
Contact
-
University Medical Center Utrecht
NOT_YET_RECRUITINGUtrecht, Utrecht, 3584 CX, Netherlands
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Targeted Muscle Reinnervation (TMR) surgery
What this could lead to
If it works, this could offer a better surgical technique to prevent chronic pain after leg amputation, improving quality of life for many patients.
What could go wrong
This is a relatively small, early-stage trial (203 participants) comparing two surgical methods. The benefit may be modest or not apply to all patients, and surgery carries standard risks like infection or nerve damage.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.