Institut Bergonié

This study tested whether combining two drugs—an immunotherapy (durvalumab) and an epigenetic drug (tazemetostat)—could help control advanced solid tumors that are hard to treat. It enrolled 164 adults with specific advanced cancers, including pancreatic, colorectal, and soft-tis…

This study tested whether a daily pill called pazopanib could control the growth of aggressive desmoid tumors better than standard chemotherapy. It involved 72 adults whose tumors were growing and causing symptoms. Participants were randomly assigned to receive either the pazopan…

This study tested whether combining an immunotherapy drug (MK3475) with a low-dose chemotherapy (cyclophosphamide) could help control advanced sarcomas. It involved 129 adults whose cancer had progressed despite prior treatments. The main goal was to see if the combination could …

This study tested whether adding a specialized geriatric care team to standard cancer treatment could help older patients. It involved 792 patients aged 70 and older with various advanced cancers. The goal was to see if this coordinated care approach improved survival and quality…

This study tested a new approach for treating a rare abdominal cancer called retroperitoneal liposarcoma. It combined a precise, high-dose form of radiation (helical tomotherapy) with surgery, aiming to better control the cancer and prevent it from coming back. The trial enrolled…

This early-stage study tested whether combining two drugs—trabectedin and durvalumab—is safe and shows promise for treating advanced soft-tissue sarcoma and ovarian cancer. The trial involved 40 patients whose cancers had progressed despite previous treatments. Researchers aimed …

This study tested whether combining two existing cancer drugs (trabectedin and cyclophosphamide) could help control advanced soft-tissue sarcoma in patients whose previous treatments had stopped working. The first phase determined the safest dose, and the second phase checked if …

This early-stage study tested whether adding a drug called olaparib to standard radiation therapy is safe and might help control advanced soft-tissue sarcomas that cannot be surgically removed. It involved 41 adults with these difficult-to-treat tumors. The main goal was to find …

This study tested a non-surgical treatment for older adults with breast cancer who could not or did not want to have an operation. Doctors used ultrasound to guide a needle that heats and destroys the tumor, combined with hormone-blocking pills. The goal was to see if this approa…

This study tested whether waiting to reconnect the bowel after rectal cancer surgery is safer than doing it immediately. It involved 124 patients with medium or lower rectal cancer. The goal was to see if the delayed method reduces serious leaks, cuts down on the need for tempora…

This study tested whether MRI scans could help find breast cancer in women who have unusual nipple discharge but whose standard mammograms and ultrasounds look normal. Researchers enrolled 70 women to see if MRI could accurately rule out cancer when it appeared normal. The goal w…

This study looked at whether checking just the first few lymph nodes (sentinel node biopsy) during a mastectomy for a type of early breast cancer called DCIS could help patients. The goal was to see if this approach could prevent the need for a more extensive lymph node removal s…

This study tested whether combining a blood test (liquid biopsy) with traditional tissue analysis could better identify specific genetic changes in patients with advanced non-small cell lung cancer. Researchers enrolled 581 newly diagnosed patients to compare how well each method…

This study looked back at medical records to see if a specialized imaging test called a PET CT scan is better than the standard CT scan at finding out if advanced bladder cancer has spread. Researchers analyzed data from 130 patients to see if the PET CT could more accurately det…

This study tested a less invasive biopsy method for diagnosing suspicious lymph nodes found on PET scans in cancer patients. Researchers wanted to see if a guided needle biopsy, done through a tube in the throat, could accurately diagnose these lymph nodes. If successful, this me…

This study tested whether adding a special contrast dye to ultrasound imaging during surgery helps surgeons see liver tumors more clearly. It involved 68 patients with colorectal cancer that had spread to the liver. The goal was to see if this enhanced imaging led surgeons to cha…

This study tested whether adding nitrous oxide (laughing gas) during a spine surgery called vertebroplasty could help reduce pain and the need for strong painkillers afterward. It focused on patients who were already taking opioid pain medications long-term before their surgery. …

This study tested whether injecting a local anesthetic (ropivacaine) into the chest cavity after lung cancer surgery could reduce severe pain. Researchers enrolled 90 patients who had major chest surgery for cancer. They compared this injection method to standard pain relief to s…

This study tested whether using technology could help improve care for people with advanced breast cancer who live far from their treatment center. Fifteen patients used tablets to report symptoms weekly and wore smartwatches that tracked their activity and sleep. Researchers wan…

This study tested whether giving ketamine during and after breast cancer surgery helps reduce pain and the need for morphine in recovery. It involved 230 women undergoing mastectomy or lumpectomy. Researchers compared pain levels and morphine use in the first 48 hours after surge…

This study looked at whether 'time until a patient needs new treatment or dies' is a good measure of how well immunotherapy drugs work for advanced melanoma. Researchers analyzed data from 631 patients with previously untreated advanced melanoma to see if this measurement accurat…

This study aimed to understand how COVID-19 antibodies change over time in hospital staff who care for vulnerable patients like those with cancer. Researchers followed 526 healthcare workers for a year, testing their blood for antibodies at the start, 3 months, and 12 months. The…

This study aimed to understand how often a specific genetic change called an NTRK fusion occurs in people with advanced solid tumors. Researchers analyzed tumor samples from over 3,800 patients who had already received cancer treatment. The goal was to gather information to help …

This study aimed to better understand how common erectile dysfunction is after rectal cancer treatment. Researchers used special sleep monitoring devices to measure nighttime erections in 12 men who had surgery for early-stage rectal cancer. The goal was to get objective data abo…

This study aimed to understand if general anesthesia during breast cancer surgery puts extra stress on the heart for patients who previously received a specific type of chemotherapy called anthracyclines. Researchers measured a blood marker (BNP) linked to heart strain before, du…

This study tested a new, standardized interview guide for doctors to use when telling a patient they have cancer. Researchers worked with 252 adult cancer patients and their caregivers to see if the guide was reliable and easy for nurses to use. The goal was to create a better, m…

This study looked back at data to understand what factors affect cancer care for people aged 65 and older. Researchers analyzed health records from 450 older adults in France diagnosed with cancer between 2005 and 2014. The goal was to see how things like age, income, and overall…

This small pilot study tested whether MRI scans could reliably measure how well breast cancer responds to chemotherapy early in treatment. Researchers enrolled 16 women with breast cancer who were scheduled to receive chemotherapy before surgery. The goal was to see if MRI measur…

This study aimed to understand if a person's genetics can predict how well the drug cetuximab works for treating advanced head and neck cancers. Researchers collected blood samples from 121 patients with recurrent or metastatic cancer to analyze specific genes. The goal was to fi…

This study looked back at the medical records of 545 patients to understand how doctors treat metastatic bone tumors in real-world settings. It focused on patients aged 12 and older diagnosed with specific bone cancers between 2008 and 2018. The goal was to describe the treatment…

This study aimed to create a better statistical method for planning future clinical trials. It focused on how to calculate the right number of participants needed when the people in the study have different risks or might respond differently to a treatment. The goal was to improv…

This study looked back at the medical records of over 2,000 adults with advanced soft tissue sarcoma to understand what treatments they received in real-world clinics and how long they lived. Researchers analyzed patterns of care, including chemotherapy and off-label drug use, to…

This project aimed to create guidelines for future cancer trials involving older adults. A panel of experts reviewed what outcomes, like maintaining independence and quality of life, are most important to measure for this group, beyond just tracking tumor growth. The goal is to h…

This study aimed to find biological markers that could predict which patients with advanced soft-tissue sarcoma would respond well to the drug trabectedin. Researchers collected tumor and blood samples from 29 adult patients before, during, and after treatment to analyze their ge…

This study analyzed existing medical records from over 20,000 women with metastatic breast cancer in France. Researchers examined real-world survival data to find faster, reliable ways to measure if cancer treatments are working. The goal is to help future clinical trials get res…

This study observed 492 adults in France with advanced gastrointestinal stromal tumor (GIST) cancer to understand how doctors treat this disease in real-world settings. Researchers looked back at patient records from 1990 to 2018 to map out the sequence of treatments used and mea…