Institut Bergonié

This early-phase study tested a drug called olaparib together with radiation therapy for people with advanced soft-tissue sarcoma that couldn't be removed by surgery. The main goal was to find the safest dose of olaparib and see how many patients had serious side effects. A total…

This study tested whether adding the drug berzosertib to standard chemotherapy (gemcitabine) can help control a rare type of soft-tissue cancer called leiomyosarcoma. Fifty-eight adults with advanced disease that had worsened despite prior treatments took part. The main goal was …

This study tested a drug called pazopanib in 72 adults with progressive desmoid tumors, which are benign but can be aggressive and hard to treat. The goal was to see if the drug could stop the tumors from growing and help patients maintain their quality of life. The main measure …

This study tested a new approach for a rare cancer called retroperitoneal liposarcoma, which grows in the abdomen. Researchers gave 48 patients a higher dose (54 Gy) of very precise radiation using a machine called helical tomotherapy before surgery. The goal was to see if this c…

This study tested a delayed surgical connection (delayed coloanal anastomosis) for people with medium or lower rectal cancer. The goal was to see if it lowers the chance of a leak at the connection site and reduces the need for a temporary or permanent stoma bag. The trial involv…

This study tested a combination of two drugs, MK3475 and low-dose cyclophosphamide, in 129 people with advanced sarcomas that could not be removed by surgery or had spread. The goal was to see if the treatment could shrink tumors or stop them from growing for at least 6 months. T…

This study tested a combination of two chemotherapy drugs, trabectedin and cyclophosphamide, in 50 adults with advanced soft-tissue sarcomas that had already been treated. The goal was to find the safest dose and see if the combo could stop the cancer from growing for at least 6 …

This study tested a combination of two drugs, durvalumab (an immunotherapy) and tazemetostat (an epigenetic therapy), in 164 adults with advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The goal was to see if the combo could shrink or stabilize tumors. …

This study tested a combination of two immunotherapy drugs, nivolumab and relatlimab, in 68 adults with advanced soft-tissue sarcoma. The goal was to see if the combo could shrink tumors or stop them from growing for at least 6 months. Participants had a specific immune feature i…

This early-phase trial tested a combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find the safest dose and check for early signs of tumor shrinkage.…

This study tested a non-surgical treatment for breast cancer in 21 patients aged 70 and older who could not or would not have surgery. Doctors used ultrasound to guide a needle that heats and destroys the tumor, combined with hormone therapy. The goal was to see if this approach …

This study looked at whether an MRI can detect breast cancer in women who have abnormal nipple discharge but normal mammograms and ultrasounds. About 70 women took part. The goal was to see how often a normal MRI correctly ruled out cancer. The results could help avoid unnecessar…

This study looked at whether MRI scans can detect early signs that chemotherapy is working in women with invasive breast cancer. Sixteen women received chemotherapy before surgery, and their MRI results were reviewed by two radiologists to check if the measurements were consisten…

This study looked at whether using an ultrasound-guided needle biopsy (called EUS-guided puncture) after a PET scan can accurately diagnose cancer in lymph nodes in the chest. The goal is to see if this less invasive method can replace more risky procedures. The study involved 75…

This study looked at whether adding ketamine to general anesthesia could lower the need for morphine and reduce pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps control pain and limits morphine's…

This study looked at whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could reduce pain and the need for morphine afterward. It included 39 adults who were already taking opioid pain medications for more than a month. The goal was to see …

This study looked at whether giving a numbing medicine (ropivacaine) into the chest during lung cancer surgery helps reduce severe pain afterward. 90 adults having surgery for lung cancer took part. The main goal was to see how many had major pain when moving after the operation.…

This study looked at whether using telemedicine (video calls), connected watches, and symptom tracking apps can help women with advanced breast cancer who live far from their cancer center. Fifteen women took part, and researchers measured their quality of life after 6 and 12 mon…

This study looked at whether a care plan led by a geriatrician and a trained nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study examined how factors like age, income, and social support influence cancer treatment and survival in people 65 and older. Researchers analyzed data from 450 elderly cancer patients in Gironde, France, to understand why some receive treatment and others do not. The goal…

This study looked at whether a common type of chemotherapy (anthracyclines) for breast cancer makes the heart more sensitive to stress during surgery with general anesthesia. Researchers measured a heart stress marker called BNP in 54 women before, during, and after breast cancer…

This study looked back at the medical records of over 2,100 adults with advanced soft tissue sarcoma to see what treatments they actually received and how long they lived. Researchers focused on how often patients got chemotherapy, surgery for their tumors, or drugs not officiall…

This study looked at whether using a contrast dye during ultrasound, done while surgery is happening, helps surgeons see liver tumors from colorectal cancer more clearly. 68 adults with operable liver metastases took part. The goal was to see if this extra imaging changed the sur…

This study examined tumor samples from 3,820 people with advanced solid cancers to find how often NTRK gene fusions appear. Researchers used genetic tests to identify these rare changes. The goal was to understand the incidence, not to test a new treatment. Participants had alrea…

This study examined whether the time until a patient needs their next treatment or dies (TNT-D) is a reliable substitute for overall survival in advanced melanoma patients receiving immune checkpoint inhibitors. Researchers analyzed data from 631 patients to see how well TNT-D ma…

This study reviewed the medical records of 545 patients aged 12 and older with bone tumors that had spread (metastatic). The goal was to understand how these patients are treated in real-world clinics and what their survival looks like. The study did not test a new treatment but …

This study looked at how many hospital workers had antibodies to the COVID-19 virus, indicating a past infection. Over 500 staff members at a French cancer center gave blood samples at the start, 3 months, and 12 months. The goal was to track immune response over time and underst…

This study examined whether FDG-PET CT scans are more accurate than standard CT scans for staging muscle-invasive bladder cancer. Researchers reviewed records of 130 patients who had PET CT scans before surgery. They compared scan results with actual findings from surgery to see …

This study examined whether certain gene variations (FCγRIIIA and FCγRIIA) influence how well the cancer drug cetuximab works in people with advanced head and neck cancers that have spread or come back. Researchers analyzed DNA from 121 participants to look for links between thes…

This study tested a questionnaire designed to help doctors and nurses talk with cancer patients and their caregivers. 252 adults with cancer and a caregiver took part. The goal was to see if the questionnaire gives consistent and reliable results when used by different healthcare…

This study looked at medical records of 492 people with metastatic GIST (a rare stomach or bowel cancer) treated in France between 1990 and 2018. Researchers wanted to see which treatments patients actually received over time, including newer drugs and procedures like surgery for…

This study looked at information from about 20,000 women with metastatic breast cancer to see if other measures, besides overall survival, could be used to judge how well treatments work. Researchers compared real-world data from medical records with results from clinical trials.…

This study brought together experts to decide what health outcomes matter most when testing cancer treatments in older adults. They focused on areas like independence, memory, mood, and nutrition, which are often overlooked in standard trials. The goal is to help future studies b…

This study looked at 228 women with ductal carcinoma in situ (DCIS) who needed a mastectomy. The goal was to see if doing a sentinel lymph node biopsy before mastectomy could help some women avoid a more extensive lymph node removal later. The researchers measured how many women …

This study looked at whether adding a simple blood test (liquid biopsy) to the standard tissue test could help find more gene changes (EGFR mutations) in people with advanced lung cancer. Over 500 patients who had not yet been treated provided both blood and tissue samples. The g…

This study created a better way to calculate how many people are needed in a clinical trial when patients have different risks or respond differently to treatment. Researchers analyzed data from 500 participants to improve trial design. The goal is to make future trials more reli…

This study aimed to objectively measure erectile dysfunction in men treated for early-stage rectal cancer. Twelve sexually active men were monitored three months after surgery using a device that records nighttime erections. The goal was to better understand a common but often un…

This study aimed to find biological markers that could predict how well the drug trabectedin works in people with certain advanced soft-tissue sarcomas. Researchers collected tumor samples and blood from 29 adults before and during treatment to look for patterns. The goal was to …