Institut Bergonié

This study tests if adding a freezing procedure called cryoablation to standard immunotherapy and chemotherapy helps people with advanced lung cancer live longer. About 214 adults with metastatic lung adenocarcinoma will be split into two groups: one gets the freezing treatment p…

This study is for people with a certain type of prostate cancer that is not too advanced but has some higher-risk features. It tests whether adding a short course of the drug darolutamide to standard radiation therapy can better control the cancer. The main goal is to see if this…

This study is testing whether adding an immune-boosting drug (BDB001) and targeted radiation to an existing immunotherapy (atezolizumab) can help control several advanced solid tumors, including pancreatic, lung, bladder, and triple-negative breast cancer. About 247 adults with t…

This study tests a combination of two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas that have not responded to standard treatments. The goal is to see if this combo can stop or shrink tumors for at least 6 months. About 119 adults with specific sarcoma t…

This study tests whether giving extra chemotherapy before surgery can help prevent the spread of a rare cancer called soft-tissue sarcoma. It involves 351 adults with high-risk, non-spread tumors. Participants receive either standard care (3 chemo cycles before surgery) or an int…

This study tests whether high-intensity focused ultrasound (HIFU) can destroy breast tumors without surgery. About 15 women with small, early-stage breast cancers will receive HIFU before their planned surgery. Researchers will check if the ultrasound completely kills the invasiv…

This study tests a new care plan that uses technology to help doctors better manage the health of older adults (70+) who have cancer and other medical conditions. The goal is to see if this approach improves their quality of life over six months. About 720 people with breast, lun…

This study is looking at certain proteins, called convertases, in pancreatic tumor samples from 50 adults. Researchers want to see if the levels of these proteins are linked to how the immune system reacts to the cancer. The goal is to find new ways to predict how the disease wil…

This study looks at whether adding a simple blood test that tracks tumor DNA (ctDNA) to regular scans can help doctors choose better treatments and improve survival. About 332 adults with advanced colorectal or non-small cell lung cancer will be randomly assigned to either standa…

This study is creating a large national database in France to collect medical and biological information from up to 150,000 people with sarcoma, a rare type of cancer. The goal is to track how patients are treated and what happens to them over time, helping researchers learn more…

This study is for people with soft-tissue sarcoma who are scheduled for chemotherapy before surgery. Researchers want to see if a genetic marker called CINSARC can predict how well the chemotherapy works. About 205 participants will provide tumor samples and be followed during tr…

This study is testing whether DNA mutations found in the blood (ctDNA) can help predict if breast cancer will return in patients who have had chemotherapy before surgery. Researchers will take blood samples over time from 180 patients whose tumors did not fully disappear after ch…

This study aims to find genetic changes in the tumors of 10,000 adults with advanced solid tumors or blood cancers. Researchers will use advanced DNA testing to look for 'actionable' alterations that could be targeted by existing drugs. Patients with a matching alteration may the…

This study gathers information from 30,000 breast cancer patients treated at Institut Bergonié since the 1990s. Researchers will analyze the data to learn about survival rates, treatment practices, and factors that affect the disease's outlook. The goal is to better understand br…

This study is developing artificial intelligence (AI) tools to help pathologists more accurately diagnose and predict the behavior of rare uterine smooth muscle tumors, including those that are hard to classify as benign or malignant. Researchers will train deep learning models o…

This study looks at a radioactive treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread. Researchers want to measure how much radiation the tumor and healthy organs receive, and see if that affects how well the treatment works or causes side effect…