Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This trial tests whether a Mediterranean diet, enriched with extra virgin olive oil or walnuts, can lower the chance of stroke and slow cognitive decline in people with cerebral amyloid angiopathy (CAA) or CADASIL, two conditions that affect blood vessels in the brain. Participan…

This study tests a non-invasive procedure called focused ultrasound for adults with limb dystonia that hasn't improved with medication or Botox. The treatment uses sound waves to create a tiny lesion in a brain area that controls movement. Researchers will compare real treatment …

This study tests whether mindfulness therapy, added to standard care, can reduce migraine attacks and improve quality of life in people with high-frequency episodic migraine. Researchers will use EEG, MEG, and wearable devices to measure brain activity before and after treatment,…

This study tests whether a postbiotic dietary supplement called PostbiotiX Comfort® can improve gut and behavioral symptoms in children with autism spectrum disorder (ASD). Researchers will give the supplement daily for one month to 90 children aged 3-8 years. They will measure c…

This study is testing whether using lower doses of the anesthetic drug propofol during brain tumor surgery helps patients wake up more quickly and fully after the operation. Researchers will enroll 100 adults having elective brain surgery and monitor their recovery. The goal is t…

This study compares two ways of giving Botox injections for cervical dystonia, a condition that causes painful neck muscle spasms. One method uses ultrasound to see the muscles, the other relies on touch and body landmarks. About 100 adults will receive both types of injections a…

This study tests a type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic face pain that has no clear physical cause. The goal is to see if changing how the brain processes pain can lower pain intensity and improve quality of life. Sixty adults will b…

Researchers at six Italian headache centers are following about 800 adults with trigeminal autonomic cephalalgias, a group of rare headaches that includes cluster headache, paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The study observes routine care rather than as…

This study looks at 100 adults with CADASIL, a genetic condition that affects small blood vessels in the brain and can lead to strokes and thinking problems. Researchers will collect genetic data, symptoms, and brain MRI images to see how these factors relate. The goal is to bett…

This small study tests a smartphone app that creates a 'digital twin' of the patient to help manage health after a stroke, moyamoya disease, or cerebral amyloid angiopathy. Twenty adults will either use the app plus standard care, or standard care alone. The goal is to see if pat…

This study looks at how people with a slow-growing brain tumor (low-grade glioma) feel during different treatments. Researchers will ask 90 patients about their quality of life, symptoms, and anxiety while they receive either the drug vorasidenib, radiotherapy, or just regular ch…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study is collecting medical data and brain scans from 500 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain and memory problems in older adults. Researchers want to better understand how the disease progresses and find markers that …

This study looks at people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. Researchers will use advanced tests to better pinpoint the seizure source and guide treatment, which may include surgery or le…

This study aims to understand how deep brain stimulation (DBS) changes brain activity in people with dystonia, a movement disorder. Researchers will use brain scans and electrical recordings from 15 participants who already have DBS implants. The goal is to learn more about the d…

This study will follow 1,000 people of all ages who are having endovascular procedures (minimally invasive treatments through blood vessels) for brain or spinal conditions like aneurysms or abnormal blood vessels. Researchers will record complications, recovery, and changes in th…

This study looks at how nerves work in people with Charcot-Marie-Tooth disease and other nerve disorders like CIDP. Researchers will use special electrical tests and ultrasound to measure nerve and muscle changes. The goal is to better understand these conditions, not to test a n…

This study watches 300 adults after brain surgery to see if heart rate patterns and brain wave activity can predict complications. Researchers will monitor patients in the recovery room for up to two hours. The goal is to find better ways to detect problems early and personalize …

This study collects blood samples from 100 children aged 3-15 with autism to create personalized cell models in the lab. Researchers will analyze these cells to understand biological differences that may contribute to autism. The goal is to gather knowledge that could one day lea…

This study aims to standardize care for people with rare brain tumors by using artificial intelligence to analyze patient data and predict recovery after surgery. Researchers will collect information on symptoms, brain scans, and cognitive function from 200 adults undergoing tumo…

This study looks at the mental health, emotions, and quality of life of 180 adults with drug-resistant focal epilepsy who are eligible for epilepsy surgery. Researchers will track changes in these areas before and after surgery to better understand how patients feel and cope. The…

This study checks whether computer models that help doctors dose the sedatives propofol and remifentanil during brain surgery also work well when patients are in the intensive care unit afterward. Researchers will compare how accurate the models are in the ICU versus during surge…

This study looks at how cholesterol and its byproducts relate to different types of dementia, including Alzheimer's and frontotemporal dementia. Researchers will measure these substances in brain tissue, spinal fluid, and blood from 80 adults aged 40-85. The goal is to find patte…

This study is testing whether a dye called sodium fluorescein can help surgeons better see and remove aggressive brain tumors during surgery. The dye is injected into the bloodstream and collects in tumors where the blood-brain barrier is broken, making them glow under a special …

This study collects blood and tissue samples from 400 people with brain aneurysms (some ruptured, some not) and 200 healthy volunteers. Researchers will analyze the participants' genes to find variations linked to a higher risk of aneurysm rupture. The goal is to create a tool th…

This study looks at how migraine affects thinking, memory, and emotions in 150 adults. Researchers will test cognitive skills and link them to mood, anxiety, and headache patterns. The goal is to better understand the full impact of migraine on daily life.

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will test the translated version with 190 Italian-speaking patients to make sure it works correctly. The goal is to give doctors a reliab…

This study follows 50 children with PTEN gene mutations to better understand their risk of developing tumors. Participants will have yearly check-ups including blood tests, ultrasounds, and skin exams for 5 years. The goal is to create better monitoring guidelines for these child…

This study is testing a new fiber optic probe that combines three technologies (fluorescence, Raman spectroscopy, and ultrasound) to help doctors see tumor tissue and blood vessels during brain biopsies. The probe will be tested on brain tumor tissue removed from 20 patients with…

This study looks at how parietal lobe gliomas (a type of brain tumor) affect a person's ability to perceive space and attention, a condition called visuospatial deficit. Researchers will test 40 patients before and after surgery using simple tasks like crossing out letters or dra…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …