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Less propofol during brain surgery may lead to quicker, safer awakening

NCT ID NCT06844838

Symptom relief Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether using lower doses of the anesthetic drug propofol during brain tumor surgery helps patients wake up more quickly and fully after the operation. Researchers will enroll 100 adults having elective brain surgery and monitor their recovery. The goal is to find the best balance between keeping patients asleep during surgery and ensuring a smooth, early awakening afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol and remifentanil (anesthetic drugs)
What this could lead to
If it works, this could lead to a standard way to give anesthesia that helps brain surgery patients wake up sooner and more clearly.
What could go wrong
This is a small, early-phase study (100 people) at one hospital. The results may not apply to all patients, and the approach might not improve outcomes or could have unknown risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing neurosurgical surgery afferent to the Department of Neurosurgery of the IRCCS Carlo Besta Neurological Institute Foundation will be consecutively enrolled from the date of study approval for 24 months.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with supra- and sub tentorial neurosurgical pathology who meet the following inclusion criteria will be enrolled: * Age greater than or equal to 18 years Exclusion Criteria: * Psychiatric illness in history and/or taking psychotropic drugs * Glasgow Coma Score (GCS) \< 15 * Presence of overt cognitive decline or speech disorders * Patients younger than 18 years of age * Intraoperative hypothermia (\< 36°) * Intraoperative hypotension (MAP \< 20% of baseline)

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Conditions

The condition(s) this trial relates to.

Pain supratentorial cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Supratentorial brain tumor surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    RECRUITING

    Milan, 20133, Italy

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