Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This study tests a non-invasive procedure called focused ultrasound for adults with limb dystonia that hasn't improved with medication or Botox. The treatment uses sound waves to create a tiny lesion in a brain area that controls movement. Researchers will compare real treatment …

This study is testing whether using lower doses of the anesthetic drug propofol during brain tumor surgery helps patients wake up more quickly and fully after the operation. Researchers will enroll 100 adults having elective brain surgery and monitor their recovery. The goal is t…

This study tests whether a postbiotic dietary supplement called PostbiotiX Comfort® can improve gut symptoms and behavior in 90 children aged 3-8 with autism. The supplement is taken daily for one month. Researchers will check gut issues, sleep, and behavior before and after trea…

This study compares two ways of giving Botox injections for cervical dystonia, a condition that causes painful neck muscle spasms. One method uses ultrasound to see the muscles, the other relies on touch and body landmarks. About 100 adults will receive both types of injections a…

This study tests a type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic face pain that has no clear physical cause. The goal is to see if changing how the brain processes pain can lower pain intensity and improve quality of life. Sixty adults will b…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study tests whether ultrasound can help doctors better understand and treat people with disorders of consciousness, like coma or a minimally conscious state, after severe brain injury. Researchers will use ultrasound to look at brain structure and function, and also try low-…

This study tests whether a substance called 5-ALA, already used during brain surgery to make tumor cells glow, can also be detected in blood or urine. Researchers hope this 'liquid biopsy' could help diagnose and monitor glioblastoma, the most common and deadly brain tumor, witho…

This study checks whether computer models that help doctors dose the sedatives propofol and remifentanil during brain surgery also work well when patients are in the intensive care unit afterward. Researchers will compare how accurate the models are in the ICU versus during surge…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This study is testing a new fiber optic needle that combines three technologies (fluorescence, Raman spectroscopy, and ultrasound) to help surgeons see tumor tissue and blood vessels in real time during brain biopsies. The goal is to make biopsies safer and more accurate by reduc…

This study looks at how cholesterol and its byproducts relate to different types of dementia, including Alzheimer's and frontotemporal dementia. Researchers will measure these substances in brain tissue, spinal fluid, and blood from 80 adults aged 40-85. The goal is to find patte…

This study aims to better understand autism by collecting skin cells from 100 children aged 3-15 with autism and turning them into stem cells in the lab. Researchers will study how these cells behave, especially brain-like cells, to learn what goes wrong in autism. No new treatme…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study looks at how parietal lobe gliomas (a type of brain tumor) affect a person's ability to perceive space and attention, a condition called visuospatial deficit. Researchers will test 40 patients before and after surgery using simple tasks like crossing out letters or dra…

This study looks at better ways to diagnose and treat people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. Researchers will test advanced imaging and other tools to pinpoint the seizure source and gu…

This small study tests a smartphone app that creates a 'digital twin' of the patient to help manage health after a stroke, moyamoya disease, or cerebral amyloid angiopathy. Twenty adults will either use the app plus standard care, or standard care alone. The goal is to see if pat…

This study looks at epigenetic changes in meningioma, the most common type of brain tumor. Researchers want to find markers in tumor tissue and blood that can predict if the tumor will come back after surgery. They will study 210 patients, both past and new, to develop and test t…

This study will follow 1,000 people of all ages who are having endovascular procedures (minimally invasive treatments through blood vessels) for brain or spinal conditions like aneurysms or abnormal blood vessels. Researchers will record complications, recovery, and changes in th…

This study is collecting medical data and brain scans from 500 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain and memory problems in older adults. Researchers aim to identify patterns and markers that predict how the disease progresse…

This study looks at how nerves work in people with Charcot-Marie-Tooth disease and other nerve disorders like CIDP. Researchers will use special electrical tests and ultrasound to measure nerve and muscle changes. The goal is to better understand these conditions, not to test a n…

This study aims to standardize care for people with rare brain tumors by using artificial intelligence to analyze patient data and predict recovery after surgery. Researchers will collect information on symptoms, brain scans, and cognitive function from 200 adults undergoing tumo…

This study listens to patients with a slow-growing brain tumor (IDH-mutant grade 2 glioma) to understand how they feel during treatment. It compares two approaches: radiotherapy and a drug called vorasidenib, plus a group just being watched. The goal is to learn which treatment b…

This study collects blood and tissue samples from 400 people with brain aneurysms (some ruptured, some not) and 200 healthy volunteers. Researchers will analyze the participants' genes to find variations linked to a higher risk of aneurysm rupture. The goal is to create a tool th…

This study looks at the mental health, emotions, and quality of life of 180 adults with drug-resistant focal epilepsy who are eligible for epilepsy surgery. Researchers will track changes in these areas before and after surgery to better understand how patients feel and cope. The…

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will test the translated version with 190 Italian-speaking patients to make sure it works correctly. The goal is to give doctors a reliab…

This study aims to understand how migraine affects thinking skills like memory and attention, and how it relates to mood, worry, and coping. Researchers will test 150 adults with migraine using cognitive assessments and questionnaires. The goal is to better characterize the migra…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study watches 300 adults after brain surgery to see if heart rate patterns and brain wave activity can predict complications. Researchers will monitor patients in the recovery room for up to two hours. The goal is to find better ways to detect problems early and personalize …

This study tests whether injecting a fluorescent dye called sodium fluorescein during brain tumor surgery helps surgeons see and remove more of the tumor. About 800 people with suspected aggressive brain or spinal cord tumors will receive the dye before surgery. The goal is to se…