Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This study compares Botox injections guided by ultrasound versus standard injections (using body landmarks) for people with cervical dystonia, a condition causing neck muscle spasms and pain. About 100 adults will receive both types of injections at different times to see which i…

This study explores whether a daily postbiotic supplement (a type of gut-health product) can reduce stomach problems and improve behavior in children with autism, ages 3 to 8. Researchers believe that fixing gut issues might help with autism symptoms. The trial involves 90 childr…

This study aims to standardize care for 200 adults with rare brain tumors by using artificial intelligence to analyze clinical, cognitive, and psychological data. Participants will undergo surgery and a home-based cognitive rehab program. The goal is to identify predictors of rec…

This study aims to find biological markers (biosignatures) in body fluids and tissues that can help doctors diagnose ALS and FTD more accurately and earlier. Researchers will analyze samples from 230 participants using advanced techniques to detect abnormal proteins and other cha…

This study looks at how attention and vision problems change over time in 40 adults with a glioma in the parietal lobe of the brain. Participants will complete thinking and vision tests before and after surgery. The goal is to better understand these deficits so doctors can creat…

This study tests whether a special dye, called sodium fluorescein, can help surgeons see and remove more of a brain tumor during surgery. The dye makes tumor tissue glow under a special microscope, making it easier to tell apart from healthy brain. About 800 people with suspected…

This study looks at how patients with a slow-growing brain tumor (IDH-mutant grade 2 glioma) feel during treatment. It compares two groups: those getting radiotherapy and those taking a drug called vorasidenib. A third group just gets regular check-ups. The goal is to understand …

This study looks at how deep brain stimulation (DBS) affects brain networks in people with dystonia, a movement disorder. Researchers will use brain scans and electrical recordings from 15 participants who already have DBS implants. The goal is to understand how DBS changes brain…

This study creates a network of hospitals across Italy to better understand and diagnose rare cerebrovascular diseases (rCVDs) like CADASIL, Fabry disease, and Moyamoya. Researchers will collect health information from 500 patients to describe the diseases' features and natural h…

This study looks for new ways to detect and track ALS earlier by studying nerve tissue and blood from 400 people with ALS or at risk. Researchers will use advanced techniques to find molecular changes that signal the start or progression of the disease. The goal is to develop rel…