Brain surgery sedation: do current dosing models work in the ICU?
NCT ID NCT06584097
First seen Feb 16, 2026 · Last updated Jun 23, 2026 · Updated 22 times
Summary
This study checks whether computer models that help doctors dose the sedatives propofol and remifentanil during brain surgery also work well when patients are in the intensive care unit afterward. Researchers will compare how accurate the models are in the ICU versus during surgery. The goal is to see if these models can be used to guide sedation after surgery, potentially improving patient comfort and safety.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fondazione IRCCS Istituto Neurologico C. Besta
RECRUITINGMilan, Milano, 20133, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Foundation IRCCS Carlo Besta Neurological Institute
RECRUITINGMilan, Italy, 20133, Italy
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
propofol and remifentanil
What this could lead to
If successful, this could improve how doctors dose these sedatives in the ICU after brain surgery, making care safer and more personalized.
What could go wrong
This is a small, early-stage study with only 42 participants, so results may not apply to all patients. It measures drug levels, not direct patient outcomes.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.