Ultrasound-Guided botox: a sharper shot for stiff necks?
NCT ID NCT07233993
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways of giving Botox injections for cervical dystonia, a condition that causes painful neck muscle spasms. One method uses ultrasound to see the muscles, the other relies on touch and body landmarks. About 100 adults will receive both types of injections at different times to see which improves quality of life more. The goal is to find out if using ultrasound makes the treatment safer and more effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- botulinum toxin type A (Botox)
- What this could lead to
- If ultrasound guidance proves better, it could become the new standard for Botox injections in cervical dystonia, improving quality of life and reducing side effects.
- What could go wrong
- This is a small, early-stage trial (100 people) comparing two injection methods, not testing a new drug. The benefit may be small or not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Minimum age 18 years old * Clinical diagnosis of Idiopathic Cervical Dystonia * On a stable dose of other medications (if any) used for focal dystonia treatment (e.g. anticholinergics and benzodiazepines) for at least 3 months prior to screening and expected to be maintained throughout the study * Treatment non-naïve to BoNT type A therapy for CD * At least 4 months have passed between the last BoNT injection at screening * Good clinical response to previous BoNT injections, on stable dosing and treatment scheme * Informed Consent as documented by signature. * Ability to perform study requirements (to attend assessment and treatments) Exclusion Criteria: * Diagnosis of other types of Cervical Dystonia (Inherited and Acquired) * Concomitant diagnosis of diseases that contraindicate the use of botulinum toxin, such as myasthenia gravis * Known hypersensitivity or allergy to Botulinum-A Toxin * Women who are pregnant or breast feeding * Intention to become pregnant during the study * Lack of safe contraception * Other clinically significant and unstable concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.). * Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant * Participation in another study with investigational drug within the 30 days preceding and during the present study * Previous enrolment into the current study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITINGMilan, Italy