Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This trial tests two ways of delivering Cyberknife radiation to people with acoustic neuromas, benign tumors on the hearing nerve. One group receives a single radiation session, while the other receives three sessions. The goal is to see which approach better preserves useful hea…

This trial tests whether having a nurse specialist coordinate care for people with Parkinson's or related conditions improves their quality of life over 12 months. Participants are randomly assigned to either standard care with their neurologist or additional support from a nurse…

This trial tests whether multisession radiosurgery, a type of focused radiation delivered in several sessions using the Cyberknife system, can safely control atypical meningiomas that remain or come back after surgery. The study enrolls adults with grade II meningiomas who have r…

This trial follows 178 adults with benign meningiomas that are large, medium-sized, or located near critical brain areas. Researchers use a robotic system called CyberKnife to deliver radiation in multiple sessions, aiming to control tumor growth while limiting damage to nearby h…

This study tests whether multisession radiosurgery, a precise form of radiation delivered in several doses, can control optic nerve sheath meningiomas, benign tumors that grow around the nerve connecting the eye to the brain. Researchers will enroll about 50 adults with a single …

This study tested a new way of delivering radiation for people with non-secreting pituitary adenomas that came back or remained after surgery. Instead of a single high dose, the radiation was given in five smaller daily doses. The goal was to see if this approach could control tu…

This study tested a personalized vaccine made from a patient's own tumor cells and immune cells (dendritic cells) for people with newly diagnosed glioblastoma, an aggressive brain cancer. The goal was to see if the vaccine is safe and can help delay tumor growth. 76 participants …

This pilot study tests whether a mindfulness program delivered through a web app can help hospitalized neurological patients and their caregivers cope with stress and anxiety. Participants learn mindfulness techniques in an initial face-to-face session, then practice via weekly o…

This study tested whether adding acceptance and commitment therapy (ACT) to standard migraine treatment could reduce monthly headache days in people with high-frequency episodic migraine (9-14 headache days per month). Sixty-four adults were randomly assigned to either standard c…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study tests whether ultrasound can help doctors better understand and treat people with disorders of consciousness, like coma or a minimally conscious state, after severe brain injury. Researchers will use ultrasound to look at brain structure and function, and also try low-…

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This completed study looked at 200 people with cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels, raising the risk of bleeding and cognitive decline. Researchers collected clinical data, brain scans, and samples of spinal fluid and bloo…

This completed study looked at how common cognitive (thinking) difficulties are in 150 people with myasthenia gravis. Researchers measured memory, attention, and other mental skills, and how these issues affect daily activities, work, and quality of life. The goal is to better un…

This completed observational study looked at 29 people with suspected normal pressure hydrocephalus (NPH), a condition where fluid builds up in the brain. Researchers used a special MRI technique called DTI-ALPS to measure the function of the brain's waste-clearing 'glymphatic sy…