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Brain MRI may predict who benefits from hydrocephalus surgery

NCT ID NCT06857136

Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed observational study looked at 29 people with suspected normal pressure hydrocephalus (NPH), a condition where fluid builds up in the brain. Researchers used a special MRI technique called DTI-ALPS to measure the function of the brain's waste-clearing 'glymphatic system.' They compared these scans to those of healthy volunteers and checked whether the MRI results could predict who would improve after a spinal tap or shunt surgery. The goal is to find a non-invasive way to guide treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a non-invasive MRI method to better diagnose NPH and predict which patients will benefit from surgery.
What could go wrong
This is a small, completed observational study with only 29 participants. The findings are preliminary and need confirmation in larger trials before changing clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

29 people

The number who actually took part.

Started

Jun 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients affected by normal pressure hydrocephalus

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Suspected NPH patients according to the following: Inclusion Criteria: * clinical and radiological diagnosis of probable NPH according to existing guidelines * age of over 50 years Exclusion Criteria: * inability to undergo MR * diagnosis of any other neurological pathology, particularly neurodegenerative or neuroinflammatory * previous neurosurgical interventions on the brain of any type. * inability to undergo general anaesthesia

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Conditions

The condition(s) this trial relates to.

hydrocephalus normal pressure hydrocephalus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hydrocephalus Normal pressure hydrocephalus

Contacts and locations

Locations

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    Milan, 20133, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.