Children's Hospital Medical Center, Cincinnati

This program provides expanded access to stiripentol for people with Dravet syndrome, a severe form of epilepsy that causes frequent, hard-to-control seizures. It is open to patients aged 6 months and older who have not responded to other treatments. The goal is to help reduce se…

This study tests whether specially designed immune cells, called viral-specific T-cells, can safely treat viral infections that occur after a solid organ transplant. The cells are made from the patient's own blood and aim to fight viruses like adenovirus, CMV, and EBV. The goal i…

This study tests the safety and benefits of hydroxyurea, a daily medication, for children aged 3 to 10 with sickle cell anemia in Africa. The goal is to make this treatment more widely available to reduce pain and complications. Children take the drug long-term to control the dis…

This study tests whether giving monthly grocery gift cards for one year to low-income families with a child recently discharged from the hospital can reduce food insecurity and unplanned return visits. About 400 families with Medicaid insurance will take part. Families in the int…

This study tests whether weight-loss surgery is better than intensive medical treatment for controlling type 2 diabetes in teenagers aged 13 to 19.9. The goal is to see which approach leads to better blood sugar control and fewer health problems. The study involves 88 participant…

This study looks at whether adding simple family history questions to a standard bleeding questionnaire can better identify children who truly have mild bleeding disorders. Because young children often haven't had major bleeding challenges yet, their own symptoms may not tell the…

This early-phase study tests whether sodium thiosulfate (STS) can prevent hearing loss in children and young adults (ages 1 month to 39 years) who are receiving cisplatin again for relapsed or hard-to-treat liver tumors (hepatoblastoma) or similar cancers. Participants will get c…

This study compares two ways of giving penicillin to children aged 5-17 with early signs of rheumatic heart disease. One group gets a shot every month, the other takes a pill twice a day. The goal is to see if the pill works just as well to stop the heart disease from getting wor…

This study looks at whether using augmentative and alternative communication (AAC) technology, like speech-generating devices, can help children who are deaf or hard of hearing improve their language and social skills. About 154 children with hearing loss and a language gap, who …

This study aims to develop and test a program where trained family navigators support caregivers of minority children with ADHD to improve treatment adherence. The program focuses on helping families stick with medication and behavioral therapy. The study involves about 108 parti…

This study tests whether an online program called Migraine Manager can help teens ages 11 to 17 with migraines have fewer headache days. About 160 teens will be split into two groups: one using the tool and one receiving general health information. The program focuses on building…

This study tests a program called Regulating Together for 144 youth with autism who struggle with intense emotions. The program teaches skills to handle emotional ups and downs, with parents reporting changes. The goal is to improve daily coping and quality of life.

This study tests whether a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) can safely reduce symptoms of depression in people with autism spectrum disorder (ASD). Researchers will compare the active treatment to a sham (placebo) procedur…

This study is collecting information on a new dialysis machine called CARPEDIEM, designed specifically for critically ill infants with kidney problems. Researchers will track how well the machine works, how long filters last, and how many babies recover kidney function. The goal …

This study is creating a new way to screen for cerebral vision impairment (CVI) in babies and young children. CVI is a leading cause of vision problems in kids, often linked to brain injuries or conditions. Researchers will test 600 children to develop a simple screening tool and…

This study aimed to use high-frequency brain signals to better understand how the brain works in people with epilepsy, migraines, and other conditions. Researchers planned to create a database of these signals to improve diagnosis and treatment. However, the study was withdrawn b…

This study looks at how single doses of baclofen, roflumilast, and memantine affect brain activity and behavior in 45 adults with Fragile X syndrome. Participants take one dose of each drug or a placebo on separate days. The goal is to measure changes in brain waves and clinical …

This study looks at 50 children with a heart condition called Fontan circulation. Researchers use a special ultrasound to measure liver stiffness before and after heart surgery. The goal is to see if these measurements can predict future liver disease and other complications. The…

This study planned to use a biomarker test called NGAL to predict which critically ill children would develop severe kidney injury. It aimed to help doctors decide when to start or stop certain treatments. However, the study was withdrawn before any patients were enrolled, so no …

This study tests whether a special technology can help deaf or hard-of-hearing children improve their language skills. About 114 children aged 3 to 10 with hearing loss and language delays will be randomly assigned to use the technology or continue their usual therapy. Researcher…

This study aims to find the genetic causes of congenital heart defects, the most common birth defect. Researchers will collect DNA and health information from 32,000 participants across multiple centers. No treatment or cure is being tested; the goal is to better understand why t…

This study aims to develop a computer model that can predict how airway surgery will affect nighttime breathing in children with Down Syndrome who have obstructive sleep apnea. Researchers will measure airway resistance during a sleep MRI to improve the model. The study involves …

This study looks at how cholestatic liver disease affects red blood cells in children over age one. Researchers will measure the strength and flexibility of red blood cells and compare them to healthy children. The goal is to learn more about the link between liver problems and r…

This study looks at how a teenager's genes and emotions influence pain after major spine surgery. Researchers will follow 880 kids aged 10-18 with scoliosis or similar conditions. The goal is to find better ways to manage pain and reduce long-term pain after surgery.

This study uses advanced MRI scans to learn how pancreatitis affects the pancreas over time and to predict complications like diabetes. About 195 children and young adults will have MRI exams, blood and stool tests, and genetic testing. The goal is to find imaging markers that ca…

This study looks at how small blood vessels in the lungs change in people with cystic fibrosis (CF). Researchers will use special scans to measure blood vessel loss and see how it relates to lung function. The goal is to better understand CF lung disease, not to test a new treatm…

This study tests whether a special type of MRI, using a harmless inhaled gas, can detect early lung function changes in people with cystic fibrosis who are starting a new triple-combination therapy. About 64 participants will be scanned before and after starting treatment, and ag…

This study is testing a special type of MRI that uses a harmless gas (xenon) to take detailed pictures of the lungs. The goal is to see if this scan can show how well treatments are working in people with interstitial lung disease, a group of conditions that scar the lungs. Resea…

This study follows 420 children in the pediatric intensive care unit (PICU) who are at risk for acute kidney injury. Researchers use a biomarker test (NGAL) and a kidney stress test to predict which children will become fluid overloaded and need dialysis. The goal is to improve h…

This study uses a new, contrast-free MRI technique to measure blood flow in the lungs of 26 children with cystic fibrosis (CF) and compare it to healthy controls. The goal is to see if blood flow problems occur before or alongside the more commonly measured airway damage. By trac…