Children's Hospital Medical Center, Cincinnati

This study looked at how effective the Rotarix vaccine is at preventing severe rotavirus infections in young children. Researchers enrolled 362 children under 6 years old who came to the hospital with vomiting and diarrhea. They compared kids who tested positive for rotavirus wit…

This study tested whether a natural sugar called 2'-fucosyllactose (2FL) is safe and can improve gut health in people receiving a bone marrow transplant. High-dose chemo and radiation often damage the gut, leading to infections and graft-versus-host disease (GVHD). The study enro…

This study looked at whether having a case manager alone is as good as having both a case manager and a peer support group to help children with rheumatic heart disease take their antibiotics on time. The study included 335 children aged 5 to 20 who were diagnosed through school-…

This study tested a parent-led program called HALO for children ages 6 to 12 whose mothers had weight-loss surgery. The goal was to help these kids, who are at higher risk for obesity, adopt healthier eating and activity habits. The program involved 35 families and measured chang…

This study tested a mobile health program to help children (ages 2–12) with newly diagnosed epilepsy take their seizure medication as prescribed. The program included education, automated reminders, and personalized feedback. The goal was to improve medication adherence, reduce s…

This early-phase study tested a combination of two drugs (pembrolizumab and decitabine) plus targeted radiation in 22 children and young adults (ages 1 to 40) with relapsed or refractory solid tumors or lymphoma that had not responded to standard treatments. The main goals were t…

This study tested a program that uses technology to help teenagers with moderate to severe asthma remember to take their daily inhaler medication. 72 teens participated, and the program tracked their inhaler use electronically. The goal was to see if the program improved how ofte…

This study tested a drug called tofacitinib in 13 young adults aged 18 to 45 with lupus that causes moderate to severe skin rashes. The goal was to see if the drug is safe and can help clear skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how we…

This study looked at better ways to find sexually transmitted infections (STIs) like gonorrhea and chlamydia in teenagers visiting emergency rooms. Researchers compared offering STI tests to everyone versus only to those with certain risk factors. The goal was to see which approa…

This study tested whether giving montelukast before surgery reduces pain and the need for strong painkillers in children aged 3-8 having their tonsils removed. Half the children received montelukast and half a placebo. Researchers tracked pain scores, opioid use, and calls or vis…

This study tested whether N-acetylcysteine (NAC), an over-the-counter antioxidant, could improve learning, behavior, and motor skills in children with neurofibromatosis type 1 (NF1). Five children aged 8–16 took part in a double-blind, placebo-controlled trial. The goal was to se…

This study tested a virtual group program called Tuning in to Kids for parents of children aged 3 to 6 with congenital heart disease. The goal was to see if parents found the program helpful and easy to use. Parents completed online surveys and attended weekly video sessions. Res…

This study looked at two ways to numb the sciatic nerve to control pain in teenagers after ACL knee surgery. 141 teens aged 10-18 took part. Researchers compared a single injection versus a continuous nerve block to see which provided better pain relief, less medication use, and …

This study looked at over 5,000 critically ill children from around the world to better understand acute kidney injury (AKI). The goal was to learn how common AKI is, what puts children at risk, and how to predict severe cases. Researchers tested a new scoring system called "rena…

This study tested a personalized program to help teens and young adults (ages 15-24) with cancer take their oral chemotherapy or preventive medications as prescribed. 70 participants were randomly assigned to either the tailored program or standard care. The goal was to see if th…

This study tested a method to find out which premature babies with a chronic lung condition called bronchopulmonary dysplasia (BPD) actually benefit from diuretic medication. Nineteen babies born before 28 weeks took part in a special 'N-of-1' trial where they switched between th…

This study tested whether a non-invasive brain stimulation technique called theta burst stimulation (iTBS) could improve motor control in 16 people aged 10-21 with Tourette syndrome. The treatment targeted a brain area linked to tic generation and was compared to a sham (fake) ve…

This study looked at how getting more sleep at the right time of day affects what teenagers eat. Researchers compared early risers (Morning Larks) and night owls to see if sleep timing changes calorie intake and food choices. The goal is to use sleep to help prevent obesity in te…

This study tested a personalized approach to help teens with ADHD and their parents decide whether to continue medication. Thirty-one teens aged 11-15 who were unsure about their ADHD medicine took part. The goal was to see if trying different medication plans could reduce uncert…

This study involved 8 children and teens with cystic fibrosis who had a history of MRSA infection and were being treated with the antibiotic ceftaroline. Researchers measured drug levels in the blood at different times to see how well the body processes the medicine. The goal was…

This study tested a remote training program for emergency medical workers to improve their skills in treating children. 133 EMS clinicians participated by practicing procedures like inserting breathing tubes and IVs on simulators and submitting videos for review. The goal was to …

This study tested a new type of MRI called Ultra Short Echo Time (UTE) to get clearer images of the lungs. Six people aged 5 and older took part, including those with healthy lungs and those with lung disease. The goal was to compare UTE MRI with traditional MRI and collect image…

This study tested a program called GET2HOME, which uses telehealth to help children with complex chronic conditions and their families after a hospital stay. The goal was to see if the program reduces urgent care visits, emergency room visits, or unplanned readmissions. 638 child…