Children's Hospital Medical Center, Cincinnati

This study is for children and young adults (ages 6–22) newly diagnosed with Crohn's disease who are starting infliximab. Researchers want to see if a computer program that calculates a personalized dose based on blood test results can help more patients achieve deep remission (n…

This study tests a new treatment for hereditary pulmonary alveolar proteinosis (hPAP), a rare lung disease. Doctors will take a patient's own lung cells, fix a faulty gene, and transplant them back into the lungs. The goal is to see if this is safe and can improve breathing. Only…

This study looks at how adding exercise to a weight loss program affects blood fats and blood vessel function in young people ages 10-20 with obesity. Participants will follow a structured weight loss program and have their blood vessel health and triglyceride levels measured ove…

This study tests whether a simple xylitol wipe applied inside the mouth twice a day can reduce bloodstream infections in children and young adults (ages 4 months to 25 years) receiving stem cell transplants. These infections often start from mouth bacteria and can be life-threate…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. The cells are designed to target specific viruses without attacking the patient's own body…

This study tests a new way to start hydroxyurea for children with sickle cell anemia. Instead of dosing based only on weight, the dose will be tailored to how each child absorbs the drug. The goal is to reduce damage to the brain, kidneys, heart, and spleen over time.

This study tests a procedure called FETO (fetal endoscopic tracheal occlusion) in pregnant women whose babies have a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm is missing or has a hole, causing the lungs to be underdeveloped. The procedure temporari…

This early study tests whether giving a bone-strengthening drug called zoledronate soon after a stem cell transplant can safely prevent bone disease and fractures in children. About 20 children aged 5 to 18 who are at high risk for bone problems will receive the drug. The goal is…

This study tests whether adding a daily pill (amitriptyline) to cognitive behavioral therapy (CBT) delivered via video is better than CBT alone for preventing migraines in children aged 7-17. Researchers will track headache days and disability over time. The goal is to find the m…

This study compares two pain management techniques—a nerve block catheter and a freezing treatment—for teens having pectus excavatum repair. The goal is to see which method helps patients recover faster, use fewer opioids, and have less numbness or nerve pain. Participants will b…

This study tests two group programs for autistic middle-schoolers (ages 11-14) who have trouble with social skills or organization. One program focuses on social skills, the other on planning and study skills. 224 children will be randomly assigned to one of the programs. The goa…

This study tests a motor training program called 'Let's Move' for infants aged 3-8 months who are at high risk for cerebral palsy. The goal is to see if the program is practical and acceptable for families, and whether it may improve motor skills. About 35 infants will participat…

This early-phase trial tests whether romiplostim, a drug that helps the body make more platelets, can prevent dangerously low platelet counts caused by chemotherapy in children with newly diagnosed Ewing sarcoma. About 26 participants will receive romiplostim alongside their stan…

This study looks at whether adding a therapy dog to a group behavioral program helps children with autism spectrum disorder manage emotional outbursts more effectively. About 240 children will take part, and researchers will track changes in emotional reactivity and engagement. T…

This study looks at how certain immune cells (eosinophils) grow, move, and work in people with eosinophilic gastrointestinal disease, food allergy, or related inflammatory conditions. Researchers will also study family members and healthy volunteers for comparison. The goal is to…

This study looks at different ways to measure how well people with eosinophilic disorders (like EoE) are doing. Researchers will compare tissue samples from endoscopies with patient questionnaires to see if simpler tests can replace invasive procedures. The goal is to find the be…

This study collects information from 200 people with hemophagocytic lymphohistiocytosis (HLH), a rare immune condition. Researchers will track how the disease is diagnosed, what treatments are used, and how patients respond over time. The goal is to better understand HLH and impr…

This study explores whether playing specially designed sounds through headphones can normalize brain activity in children with Fragile X syndrome, ages 5-10. The goal is to see if this sound technique improves learning and reduces sensitivity to noise. Researchers will compare re…

This study is creating a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health over time. No trea…

This study is testing a new type of MRI that uses xenon gas to take detailed pictures of lung function. Researchers want to see if it works well in healthy people and those with breathing problems. About 300 people ages 6 and older will participate. The goal is to improve how doc…

This study looks at new ways to measure lung changes in people with cystic fibrosis (CF) aged 12 to 21. Researchers will use a special MRI with a breathable gas called Xenon and a breathing test called LCI to see what happens when patients stop and restart their usual airway clea…

This study looks at how a brain area called the pre-SMA affects impulse control in teens with ADHD. Researchers will use a non-invasive technique called TMS to stimulate this area and measure brain activity. The goal is to better understand ADHD, not to treat it. Forty teens aged…