Children's Hospital Medical Center, Cincinnati

This study looks at whether providing monthly grocery gift cards for one year to low-income families can reduce food insecurity and lower the chance that a child needs to return to the hospital or emergency room. About 400 families with a child recently discharged from the hospit…

This program provides expanded access to the drug stiripentol for people with Dravet syndrome, a severe form of epilepsy that causes frequent, hard-to-control seizures. It is open to patients aged 6 months and older who have not responded to other treatments. The goal is to help …

This study looks at whether taking penicillin twice a day by mouth is as good as getting a monthly shot to stop rheumatic heart disease from getting worse in children aged 5 to 17. The trial involves over 1,000 children with early signs of heart valve damage. If oral penicillin w…

This study looks at whether using augmentative and alternative communication (AAC) technology can help children who are deaf or hard of hearing develop better language skills. About 154 children will either receive AAC tools along with their regular speech therapy or continue wit…

This study tests a program where family navigators support caregivers of minority children with ADHD to help them follow treatment plans. The goal is to improve how consistently children take medication or attend behavioral therapy. The study involves about 108 participants and f…

This study tests whether a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) can safely reduce symptoms of depression in people with autism spectrum disorder (ASD). Researchers will compare the active treatment to a sham (placebo) procedur…

This study uses a new, contrast-free MRI technique to measure blood flow in the lungs of 26 children with cystic fibrosis (CF) and compare it to healthy controls. The goal is to see if blood flow problems occur before or alongside the more commonly measured airway damage. By trac…

This study looks at 50 children with a single ventricle heart condition who need Fontan surgery. Researchers use a special ultrasound to measure liver stiffness before and after surgery. The goal is to see if changes in liver stiffness can predict future complications like liver …

This study tests a special MRI scan that uses inhaled gas to create detailed images of lung function in people with cystic fibrosis. Researchers want to see if this scan can detect early lung changes better than current tests, especially for those on new triple-combination therap…

This study follows 1500 healthy infants from birth to age 4 to understand how their first exposure to influenza—either through vaccination or natural infection—affects their immune system's response to future flu exposures. Pregnant mothers are enrolled before delivery, and their…

This study is testing a special MRI technique that uses a harmless gas (xenon) to take detailed pictures of the lungs. The goal is to see how well treatments are working in people with interstitial lung disease, a group of conditions that cause lung scarring. Researchers will inc…

This study follows 420 children in the pediatric intensive care unit (PICU) who are at risk for acute kidney injury. Researchers use a biomarker test (NGAL) and a kidney stress test to predict which children will become fluid overloaded and need dialysis. The goal is to improve h…

This study uses MRI scans to learn more about pancreatitis (inflammation of the pancreas) and how it can lead to long-term problems like diabetes and digestive issues. About 195 children and young adults will have MRI exams, blood tests, and other procedures to see if MRI measure…

This study gathers information on a new dialysis machine (CARPEDIEM) designed specifically for critically ill infants with kidney failure. Researchers will track up to 1,000 babies across the U.S. to learn the best ways to use the machine, how well it works, and whether it helps …

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors better manage fluids and dialysis timing. However, the study was withdrawn before enrolling any participan…