PREGNANCY RELATED

This study looks at whether a special form of folic acid (5-MTHF) can improve blood vessel health in pregnant women with high blood pressure or pre-eclampsia. Researchers will measure key molecules in the blood, placenta, and umbilical cord to see if the supplement helps. The tri…

This study tests whether membrane stripping (a gentle finger sweep to separate the amniotic sac from the cervix) works as well as a double balloon catheter for ripening the cervix in women whose labor needs to be induced. About 400 full-term pregnant women will be randomly assign…

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This study tests a problem-solving program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program also addresses depression and anxiety, which can make it harder to stick with PrEP. Researchers will enroll 132 pregnant women, …

This study tests whether giving iron through a vein (IV) early in the second trimester works better than iron pills for treating anemia in pregnancy. About 80 pregnant women with mild iron deficiency will be randomly assigned to one of the two treatments. The goal is to see which…

This study looks at whether giving regular blood transfusions to pregnant women with sickle cell disease can reduce serious health problems for both mother and baby. About 50 women will be randomly assigned to receive either repeated transfusions or standard care during pregnancy…

This study tests whether delivering medically tailored groceries to the homes of pregnant women on Medicaid can reduce food insecurity and improve birth outcomes like preterm birth and low birth weight. About 360 pregnant women in Cuyahoga County, Ohio, will receive home-delivere…

This study looks at whether using data to track bias and providing doula support can improve pregnancy outcomes for Black mothers. About 60,000 patients at 39 prenatal clinics in North Carolina will take part. The goal is to reduce the number of low-birthweight babies and improve…

This study looks at 900 women who want permanent birth control during a C-section. It compares two ways to remove the fallopian tubes: using a special energy tool versus traditional stitches. The goal is to see which method is safer and costs less.

This study aims to find out if two common eating disorder questionnaires can accurately detect eating disorders in pregnant women, separating them from normal pregnancy-related eating concerns. Researchers will compare answers from 50 pregnant women with and without diagnosed eat…

This study is developing a blood test that can determine the father of a fetus without any risk to the pregnancy. It is designed for victims of sexual assault who become pregnant and need to know paternity for legal reasons. The test analyzes fetal DNA found naturally in the moth…

This study looks at the safety of two HIV prevention methods (a long-acting shot and daily pills) in pregnant and breastfeeding women in Malawi. About 621 women who are already using or start these drugs during pregnancy will be followed along with their infants. The goal is to s…

This study tests whether sexual counseling based on the extended plissit model can improve sexual function, marital adjustment, and emotional health in pregnant women. About 70 pregnant women between 16-20 weeks will be randomly assigned to receive the counseling or standard care…

This study tests whether giving progesterone (a hormone) after intrauterine insemination (IUI) with mild ovarian stimulation increases the chance of a live birth. About 1,000 couples with unexplained infertility will take part. The goal is to see if this simple support can improv…

This study tests whether massaging the perineal muscles with a pelvic wand during late pregnancy and labor helps women feel more in control during childbirth and improves pelvic recovery. About 140 pregnant women planning to give birth at Beth Israel Deaconess Medical Center will…

This pilot study tests whether participating in the Lullaby Project—where pregnant women with epilepsy work with musicians to create a personal lullaby—can improve their quality of life and reduce anxiety, depression, and stress. Thirty first-time pregnant women with epilepsy wil…

This study tests whether 8 weeks of diaphragmatic breathing or pelvic stabilization exercises, done at home via video calls, can reduce pain and disability in 60 postpartum women with pregnancy-related pelvic girdle pain. Participants will also receive pelvic anatomy education. T…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study tests a program called Care4mommies that teaches self-compassion skills to pregnant women. The goal is to see if it helps mothers feel better emotionally and bond more strongly with their babies after birth. About 96 pregnant women will take part, and researchers will …

This study tests a mobile app called BumptUp to see if it helps pregnant and postpartum women in rural areas become more physically active. About 176 women will either use the app or receive an educational brochure. Researchers will track activity levels, weight, diet, blood pres…

This study interviews women who gave birth in French-speaking Belgium within the last year to understand why they chose a particular place of birth and how their childbirth experience was. Researchers also talk to birth companions like doulas and healthcare professionals. The goa…

This study tests whether adjusting room light during labor can improve uterine contractions. Researchers believe darkness or red light may boost melatonin, a hormone that helps contractions. 100 pregnant women will have their light exposure and contractions monitored. The goal is…

This study tests whether pregnant women with complications like pre-eclampsia or fetal growth restriction can use a remote device at home to monitor their baby's heart rate. Sixty participants between 32 and 37 weeks of pregnancy will try the device daily. Researchers will check …

This study follows 825 pregnant women who need blood thinners for blood clots, observing how these medications are managed around labor and delivery. Researchers aim to see how different strategies affect bleeding risks. The goal is to find safer ways to handle blood thinners dur…

This study looks at whether eating more eggs during pregnancy can improve a baby's brain development. Researchers will ask 100 pregnant women to eat 10-14 eggs per week or follow a standard healthy diet. They will measure the baby's heart rate before birth and brain activity afte…

This study is testing whether a new wireless skin sensor system can safely and accurately monitor the heart rate, breathing, oxygen levels, and temperature of healthy newborns right after birth. 600 babies will wear both the wireless sensors and standard wired monitors for the fi…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study tests if wrist-worn devices can safely monitor pregnant women with congenital heart disease at home. Researchers will track heart rhythms and other signs to catch problems early. About 50 women will wear the devices and share their experience. The goal is to improve ca…

This study is collecting information on pregnancy and malaria in 9,500 women aged 15-49 in Kalifabougou, Mali. Researchers will track pregnancies, malaria cases, and pregnancy outcomes like preterm birth and anemia. The goal is to better understand these health issues in the comm…

This study follows up to 20 people of any age who took the drug odevixibat while pregnant or breastfeeding. Researchers will collect routine medical data to see if the drug is linked to birth defects, pregnancy complications, or harm to the baby. No extra tests or visits are requ…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study looks at how pregnant and non-pregnant people recover after being in the intensive care unit (ICU) for severe COVID-19. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to understand the lon…

This study, called UPLIFT, is observing 1,150 women with HIV in the United States to understand their infant feeding choices and outcomes. Researchers will use interviews and surveys to explore the medical, social, and behavioral factors behind decisions to breastfeed or formula-…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) to better serve Black women and birthing persons. Researchers will work with community advisors and local organizations to identify barriers and facilitators to implementation. The goal is to create…

This study examines whether using ruxolitinib cream for eczema during pregnancy affects infant health compared to using standard steroid creams. Researchers will analyze health records of over 5,600 women to track birth defects, birth weight, and pregnancy outcomes. The goal is t…

This study looks at how anti-seizure medications are processed in the bodies of pregnant women with epilepsy. Researchers will measure drug levels in the blood and urine to understand how much reaches the unborn baby and nursing infant. The goal is to help doctors choose safer do…

This study tests whether small wearable sensors can accurately track movement and walking patterns in 30 pregnant women during early labor, both with and without a low-dose epidural. The goal is to see if these sensors can help monitor pain relief effectiveness, predict fall risk…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track health outcomes for both mothers and babies, such as relapse and withdrawal symptoms. The goal is to find better ways to predict and prevent complic…

This study aims to develop a smarter computer program that can separate a baby's heartbeat from the mother's heartbeat using a simple belly sensor. Researchers will collect recordings from 350 pregnant women in their second or third trimester. The goal is to make fetal monitoring…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This study monitors the safety of the heart medication mavacamten when taken during pregnancy or while breastfeeding. Researchers will track pregnancy outcomes and infant health for up to one year after birth. The goal is to better understand any risks to mothers and babies. Abou…

This study is testing a special camera (Mueller polarimetric colposcopy) to see if it can measure changes in the cervix during pregnancy. The goal is to find patterns that could help predict if a baby will be born early (preterm). Researchers will study 683 pregnant women, both w…

This study is watching how the heart and blood vessels change during pregnancy and after childbirth. Researchers will measure heart rate, blood pressure, and blood flow in 242 healthy pregnant women. The goal is to learn what is normal so doctors can better spot problems early.

This study looks at whether simulation training for doctors, nurses, and midwives can reduce the number of cervical exams women receive during labor and make exam results more consistent. Over 1,100 healthcare providers and patients will take part. The goal is to improve care wit…

This study looks at pregnant women with mild to moderate eczema (atopic dermatitis) who use ruxolitinib cream and compares their babies' health to those who don't use the cream. Researchers want to see if the cream affects the risk of birth defects. About 958 women aged 15-50 wil…

This study follows 200 pregnant women who take tildrakizumab for conditions like psoriasis, along with a similar group who don't take the drug. Researchers track pregnancy outcomes and infant health up to one year after birth to check for birth defects or other problems. The goal…

This study uses MRI scans to measure pancreas size in pregnant women and their unborn babies. Researchers want to see how the pancreas changes during pregnancy and how those changes are linked to diabetes. The goal is to better understand diabetes risk for both mother and child. …

This study is testing whether a program originally designed for clinics can work in community settings to help pregnant women with a BMI over 30 stay active and healthy. Researchers will enroll 60 expecting mothers to see if the program is easy to use and follow. The goal is to l…

This study follows 60 women with neuromyelitis optica spectrum disorder (NMOSD) who received UPLIZNA during pregnancy or within 6 months before conception. Researchers will collect data on pregnancy outcomes, including birth defects, preterm birth, and infant development over 10 …

This study tests a fully online sexual health program called Yes and Know for teens aged 14-19. About 1,200 participants will be split into two groups: one gets the sexual health program, the other gets a nutrition program. Researchers will survey them at the start, 3 months, and…