POSTTRAUMATIC STRESS DISORDER

This study adapts a proven PTSD treatment (STAIR-NT) for people in methadone programs who also use cocaine and opioids. About 80 participants will either get the adapted therapy or usual care. The goal is to see if the therapy is practical, acceptable, and helps reduce drug use a…

This study tests a small device that stimulates a nerve in the ear to see if it helps people with both PTSD and opioid use disorder stay on their buprenorphine medication. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if t…

This early-stage study tests whether ketamine-assisted psychotherapy is safe and feasible for adolescents aged 15-17 with severe posttraumatic stress disorder (PTSD). Five participants will receive three intravenous ketamine doses over six weeks, each paired with psychotherapy se…

This study compares three approaches for treating PTSD in military veterans: talk therapy (Prolonged Exposure), antidepressant medication (paroxetine or venlafaxine), or both together. About 300 veterans from six VA medical centers will be randomly assigned to one of these treatm…

This study looks at how women recover from PTSD and heavy drinking after a sexual assault. Researchers want to understand what helps and test better ways to treat both problems together. About 82 women who experienced assault in the past year and have PTSD and heavy alcohol use w…

This study looks at how children with cancer and their parents handle the emotional challenges of the disease. Instead of focusing only on negative effects like posttraumatic stress, it also explores positive changes and personal growth. Researchers will compare children with can…

This study explores whether a single type of therapy (transdiagnostic CBT) can work as well as different therapies tailored to specific anxiety disorders like panic disorder or social anxiety. Researchers will check if it's possible to run a larger trial by looking at how many pe…

This study looks at whether two easy tests—checking how blood pressure changes when standing and how the eye reacts to light—can predict if a person with PTSD will respond well to the medication prazosin. The goal is to personalize PTSD treatment and understand why some people de…

This study looks at how PTSD changes the brain, genes, and behavior in 130 adults who experienced childhood trauma. Participants receive cognitive processing therapy, and researchers use brain scans and tests to track recovery. The goal is to understand why PTSD happens and how t…