Blood pressure and eye tests may guide PTSD treatment
NCT ID NCT03539614
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This Phase 3 trial tests whether two easy tests—measuring blood pressure changes when standing and eye reactions to light—can predict which veterans with PTSD will respond to the drug prazosin. The study involves 87 veterans and compares prazosin to a placebo. The goal is to personalize PTSD treatment by identifying who is most likely to benefit from this medication.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, 98108-1532, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prazosin (Minipress), a blood pressure drug also used for PTSD symptoms
What this could lead to
If successful, this could help doctors predict which PTSD patients will respond to prazosin, making treatment more personalized and effective.
What could go wrong
This is a small, early-stage biomarker study (87 veterans). The tests may not reliably predict response, and prazosin doesn't work for everyone. Results may not apply to non-veterans.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.