PANCREAS CANCER

This study tests whether adding two targeted drugs (defactinib and avutometinib) to a precise form of radiation therapy can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 participants will receive the combination treatment. The goal…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to target cancer cells while sparing healthy ones. The goal …

This early-phase study tests whether adding a procedure called irreversible electroporation (IRE) — which uses electric pulses to destroy cancer cells — to standard chemotherapy can help people with locally advanced pancreatic cancer. About 20 adults with stage III pancreatic can…

This study tests if injecting a medical glue into the pancreas during surgery can prevent dangerous fluid leaks. About 90 adults with pancreatic or nearby cancers who are having a Whipple procedure will take part. The glue is meant to strengthen the connection between the pancrea…

This study tests whether using multiple treatments together (like surgery, radiation, and chemotherapy) can help people with pancreatic cancer that has spread to only a few places in the body live longer and keep the cancer from growing. About 80 adults with this type of cancer w…

This early-phase study tests whether injecting a medical glue into the pancreas during surgery can help prevent dangerous leaks. About 30 adults with pancreas or nearby cancers will receive the glue injection as part of their standard surgery. The goal is to see if this simple ad…

This study tests a new treatment for pancreatic cancer that has spread to the liver. It combines three chemotherapy drugs with a device that delivers low-intensity electric fields to the tumor area. The goal is to see if this combination is safe and can help control the disease. …

This study tests whether using virtual reality (VR) can reduce belly pain and improve daily life for people with digestive tract cancers. 360 participants will be randomly assigned to one of three groups: skills-based VR, distraction VR, or a sham VR. Researchers will track pain,…

This study aims to improve early detection of pancreatic cancer by following 20,000 people who have a family history of the disease or carry certain gene changes that raise their risk. Participants will be monitored over time to see who develops cancer. The goal is to learn how t…

This study looks at proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if the levels of these proteins are linked to the immune cells around the tumor, which might help predict how the disease will progress. The goal is to find new w…

This study is for people with pancreatic cancer that can be surgically removed. Researchers want to see if tiny pieces of tumor DNA found in the blood (ctDNA) can help predict how long patients live. The goal is to gather information that may lead to better tests and treatments i…

This study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. Researchers will analyze the tumors for genetic changes and store participants' own T cells for possible future use in making a personalized CA…

This study collects tumor and normal tissue samples from people already scheduled for surgery or biopsy at the NIH Clinical Center. The goal is to provide researchers with samples to discover new molecular targets for cancer therapies. Up to 1800 adults and children (age 2+) with…

This study aims to find better ways to detect pancreas cancer early in people at high risk due to family history or genetic mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 volunteers during routine endoscopy. The goal is to identify mark…