PANCREAS CANCER

This study is for people with advanced pancreatic cancer that has spread and hasn't been treated yet. It tests whether adding two new drugs (avutometinib and defactinib) to standard chemotherapy can shrink tumors better. The goal is to find the safest dose and see how well the co…

This early-phase study tests whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer. The study includes 19 adults whose cancer has spread. The main goal is to check for side effects and s…

This early-phase study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. The idea is that cancer cells need lots of cholesterol to grow, and cutting off their supply …

This early-stage study tests a new drug, TORL-2-307-ADC, in people with advanced solid tumors, including gastric, pancreatic, and gastroesophageal junction cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 163 participan…

This early-stage study tests an experimental drug called MOMA-313, taken as a pill, either alone or with another drug (olaparib), in people with advanced solid tumors that have a specific DNA repair problem. The main goal is to check safety and find the best dose. About 220 adult…

This study tests whether adding a drug called defactinib (a FAK inhibitor) to precise, high-dose radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with locally advanced, inoperable pancreatic cancer will take part. The main…

This study looks at whether a supervised exercise program is safe and practical for people with pancreatic cancer. Sixteen participants will attend exercise sessions before their main treatment. The goal is to see if at least half of them can stick with the program, and to check …

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This study looks at a different way to offer genetic testing to people with ovarian, prostate, or pancreas cancer. Instead of always sending patients to a genetic counselor, doctors may offer the test directly, and counselors share results by phone. The goal is to see how this af…

This study looks at how the bacteria living in your body (the microbiome) might influence recovery and long-term health after surgery for pancreatic or related cancers. Researchers will collect samples like saliva, stool, blood, and tumor tissue from 200 adults before and after s…

This study is gathering information from 200 people with pancreatic cancer to see if analyzing their tumor's genes and creating mini-tumors in a lab can help doctors choose more personalized treatments. Participants provide tissue and blood samples, and researchers track their he…