PANCREAS CANCER

This early-phase trial is testing whether adding an experimental drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe and tolerable for people with advanced pancreatic cancer. The study involves 19 participants and primarily looks at side effects. I…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery (intraoperative radiation therapy, or IORT) can help people with pancreatic cancer that has grown into nearby blood vessels. Participants first receive standard chemotherapy and radia…

This early-phase study tests a new oral drug called MOMA-313, alone or with another drug (olaparib), in people with advanced solid tumors that have certain DNA repair flaws. The main goals are to check safety and find the right dose. About 220 adults with cancers like prostate, p…

This phase II trial tests an adaptive chemotherapy approach for people with pancreatic cancer that can be surgically removed or is borderline removable. The goal is to see if adjusting the chemotherapy regimen based on early response can increase the number of patients who become…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This study tests a precise, high-dose radiation method called SBRT given after surgery for pancreatic cancer. The goal is to lower the chance of cancer coming back in the pancreas area. About 50 adults with certain high-risk features (like positive lymph nodes or close surgical m…

This early-phase study tests whether using electric pulses to deliver chemotherapy (bleomycin) to the area where a pancreatic tumor was removed can lower the chance of cancer coming back. About 10 to 20 adults with resectable pancreatic cancer will receive this treatment right af…

This study tests a new combination of drugs (avutometinib and defactinib) added to standard chemotherapy for people with advanced pancreatic cancer that has spread. The goal is to see if the new combo is safe and can shrink tumors better than chemo alone. About 40 adults who have…

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with inoperable pancreatic cancer will take part. The goal is to see if the combination slows cancer gro…

This early-stage study tests a new drug, TORL-2-307-ADC, in 163 people with advanced solid tumors like stomach, pancreas, or esophageal cancer. The goal is to find a safe dose and see if the drug can shrink tumors. Participants must have measurable disease and be well enough for …

This early study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop pancreatic cancer growth. Cancer cells need lots of cholesterol to grow, and this approach aims to starve them. The trial inc…

This study is testing whether a 6-week supervised exercise program is practical and safe for people with pancreatic cancer. Sixteen participants will do aerobic and resistance training three times a week, plus home exercise tracked by a FitBit. The main goal is to see if patients…

This early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. The study enrolls 24 adults aged 19-85 with stage IV or in…

This study looks at whether ketorolac, a common anti-inflammatory drug, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (severe weight loss). About 28 participants will take the drug four times daily for fi…

This study enrolls 200 people with pancreatic cancer across Ontario. Researchers collect tumor tissue, blood, and stool samples to perform genetic sequencing and grow mini-tumors in the lab. The goal is to see if this detailed analysis helps more patients receive a treatment matc…

This study aims to understand how the bacteria living in your body (the microbiome) influence recovery after surgery for pancreatic or related cancers. Researchers will collect saliva, blood, stool, and tumor samples from 200 adult patients before and after surgery. The goal is t…

This study explores whether ultrasound images analyzed by a special computer program can accurately measure the size of liver tumors in people with pancreatic or gastrointestinal cancer that has spread to the liver. Participants will have both a routine contrast-enhanced CT scan …

This study looks at a new approach to genetic testing for people with ovarian, prostate, or pancreas cancer. Instead of referring patients to a genetic counselor, doctors offer the test directly, and counselors share results by phone. The goal is to see how this affects patient d…