PANCREAS CANCER

This early-stage trial is testing a combination of two chemotherapy drugs (melphalan and BCNU) plus vitamins B12b and C, followed by an infusion of the patient's own stem cells. The goal is to see if this approach is safe for people with metastatic pancreatic or breast cancer, es…

This early-stage trial tests a new drug called QXL138AM in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. The drug is designed to help the immune system attack cancer cells. The main goal is to check safety and find the…

This phase 2 trial is testing whether adding the immunotherapy drug sintilimab to chemotherapy and radiation can help people with inoperable pancreatic cancer live longer. The study will enroll 25 participants who have not had prior treatment. Researchers will track how long the …

This study tests a device called the HistoSonics Edison System, which uses focused sound waves (histotripsy) to mechanically break apart pancreatic tumors without surgery. The trial will enroll 50 adults with advanced pancreatic cancer that cannot be removed surgically. The main …

This phase 2 trial tests whether adding two drugs (defactinib and avutometinib) to targeted radiation therapy can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 participants will receive the combination treatment. The study compares…

This study tests whether giving patients drugs that match their tumor's unique molecular profile can prevent pancreatic cancer from coming back after surgery. It includes 40 adults whose cancer was removed but who are at high risk of recurrence. Researchers will track how long pa…

This study is testing a new way to deliver radiation therapy called SMART, which uses real-time MRI images to precisely target tumors. The goal is to see if this approach is safe and effective for treating various cancers, including pancreas, lung, and prostate cancer. Researcher…

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This study tests whether adding a device that sends low-intensity electric fields (tumor treating fields) to standard radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. About 48 participants will receive radiation for 5 days and use the devic…

This study tests whether injecting a medical glue (N-butyl-2-cyanoacrylate) into the pancreas during surgery can prevent dangerous leaks. About 90 patients with pancreatic or nearby cancers will receive either standard surgery or surgery plus the glue injection. The goal is to se…

This early-stage study is testing a new treatment called CEA-targeted CAR-T cells for people with advanced solid tumors like lung, stomach, colon, rectal, esophageal, or pancreatic cancer that have not responded to standard therapies. The treatment uses a patient's own immune cel…

This early study tests if injecting a medical glue into the pancreas during surgery can help prevent dangerous fluid leaks. About 30 people having pancreas tumor removal will receive the glue. The goal is to see if the glue makes the surgical connection stronger and reduces compl…

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This early-phase study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses a patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side eff…

This study tests a new drug, KESONOTIDE™, in adults with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The goal is to check the drug's safety and how the body processes it. About 80 participants will receive the drug in two …

This phase 3 trial tests whether a multi-disciplinary treatment plan can help people with pancreatic cancer that has spread to only a few other places in the body live longer without the disease getting worse. About 80 adults with this condition will receive either standard care …

This early-phase trial is testing whether adding tumor treatment fields (TTF) — a device that delivers low-intensity electric fields to disrupt cancer cell division — to a three-drug chemotherapy regimen can safely control metastatic pancreatic cancer. About 40 adults with pancre…

This study tests a new treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The treatment uses the patient's own immune cells, which are mixed with a special antibody to help them attack cancer cells. Participants receive these cells through an …

This study tests a high-dose, short-course radiation treatment for people with locally advanced pancreatic cancer that cannot be surgically removed. The goal is to see if this approach can control tumor growth in the treated area for at least two years. The trial will enroll 30 p…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This study tests whether adding a medical glue (Glubran 2) to the surgical connection in the pancreas can prevent a serious complication called pancreatic fistula, which is a leak of digestive fluids. About 100 adults undergoing pancreas removal for cancer will be randomly assign…

This early-stage study tests whether adding a procedure called irreversible electroporation (IRE) to standard chemotherapy can help control locally advanced pancreatic cancer. IRE uses short electric pulses to destroy cancer cells. The study will enroll 20 adults with stage III p…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study is testing a software called Lipidica that analyzes fats in the blood to help screen for pancreatic cancer. Researchers will compare results from people with pancreatic cancer to those at high risk (due to family history or genetic factors) to see if the software can t…

This study is testing a new, focused MRI scan of the pancreas to see if it can detect pancreatic cancer earlier in people at high risk. About 79 participants with a strong family history or certain genetic mutations will get both the new scan and a standard one. The goal is to im…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study tests whether a smartphone app, combined with nutrition education, can help people at high risk for cancer eat healthier and reduce their cancer risk. About 170 participants will either get the app or standard advice, and researchers will measure changes in diet qualit…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study is for people with pancreatic cancer that hasn't spread. Researchers want to see if they can find bits of tumor DNA in the blood before, during, and after chemotherapy. By tracking these DNA levels, they hope to learn if the blood test can help predict how well the tre…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

This study is looking at tiny pieces of tumor DNA (ctDNA) in the blood of 50 people with pancreatic cancer that can be surgically removed. Researchers want to see how often ctDNA is found and whether it relates to how long patients live without the cancer getting worse. The goal …

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study collects tumor and normal tissue samples from people already scheduled for surgery or biopsy at the NIH Clinical Center. Researchers will use these samples to study new ways to treat solid tumors. Up to 1,800 adults and children (age 2 and older) with precancerous or c…

This study is for people with cervical or pancreatic cancer who are scheduled to receive chemoradiotherapy. Researchers will collect tumor samples, blood, and imaging data before, during, and after treatment to see how the tumor environment changes over time. The goal is to learn…

This study collects blood samples from 30 adults with pancreatic cancer to build a library for future research. The goal is to store specimens and health data together, creating a powerful tool for scientists to study the disease. Participants must be patients at the University o…

This study is looking at whether a blood test that detects tiny bits of tumor DNA (called ctDNA) can help doctors better manage treatment for people with cancers of the digestive system, including pancreas, colon, and bile duct cancers. About 100 adults with these cancers will pr…

This study looks at certain proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if the levels of these proteins are linked to the immune cells around the tumor. The goal is to find new ways to predict how the disease will progress, no…

This study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand which cancers might respond to a future CAR T-cell therapy and to store participants' own immune cells for potential …

This study creates a registry of people with pancreatic diseases or a high risk for pancreatic cancer, such as those with a family history or certain genetic mutations. Researchers will collect medical information and blood samples to study how these conditions develop over time.…

This study follows 20,000 people who have a family history of pancreatic cancer or carry certain gene changes that raise their risk. Researchers will track them over time to learn how to detect pancreatic cancer earlier and possibly prevent it. The goal is to improve survival by …

This study is developing and testing a mobile app designed to help Black people with pancreatic cancer learn about and discuss clinical trials with their doctors. The goal is to increase their participation in these trials, which is currently much lower than for White patients. R…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts behave over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and samples, but no new treatment is …

This study aims to find better ways to detect pancreas cancer early in people who are at high risk due to family history or certain gene mutations. Researchers will collect and analyze pancreatic juice and cyst fluid from 9,000 participants to look for markers that signal early c…