OVERWEIGHT OR OBESITY

This early-stage study tests a new drug called IBI3032 in people who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it over four weeks of treatment. About 79 participants will receive either the drug or a placebo. This is …

This study tests a new drug called MET097 to help people with obesity or overweight lose weight. Participants receive weekly injections for 12 weeks, then switch to monthly doses for up to 64 weeks. The goal is to see if the drug is safe and effective compared to a placebo. About…

This study tests an oral medication called orforglipron, taken once daily, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea. About 3,100 participants will receive either the drug or a placebo for 72 weeks, w…

This study compares two ways to lose weight and reduce liver damage in people with cardiometabolic risks like type 2 diabetes or obesity. One group will follow a Mediterranean diet with intermittent fasting, while the other group takes a weight-loss medication (naltrexone/bupropi…

This study tests a new once-weekly injection called MET097 to help people with obesity or overweight lose weight. About 225 adults will receive either MET097 or a placebo for 28 weeks. The main goal is to see how much weight they lose compared to those on placebo.

This study tests a once-daily medication called orforglipron in 600 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The goal is to see if the drug improves breathing during sleep and reduces related health risks. Participants either…

This study looks at whether adding CPAP therapy (a machine that helps you breathe during sleep) to standard lifestyle changes can lower the risk of developing diabetes in people who have prediabetes and are overweight. About 174 participants will be followed for 6 months to see i…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) before and after a type of weight-loss surgery called sleeve gastrectomy. About 30 adults who are overweight and have NASH or prediabetes will take part. Th…

This study looks at how natural compounds in strawberries and raspberries (polyphenols) interact with gut bacteria to reduce inflammation. Overweight adults with mild inflammation will eat berry-based foods or a control diet for 4 weeks. Researchers will measure changes in blood …

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This pilot study explores whether a remotely delivered resistance training program is practical and well-liked by Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. The study will enroll 37 participants and measure how many join,…

This study aims to help 880 adults in rural Pennsylvania who are overweight, have type 2 diabetes, or are not very active. Researchers will test different ways to encourage more physical activity. Participants will report their activity and wear a device to track it.

This study aimed to see how gut bacteria and blood chemicals change in overweight or obese adults following a special low-carb diet. Participants would provide stool and blood samples as they lost weight. The goal was to understand how diet affects gut health during weight loss.