OVERWEIGHT OR OBESITY

This study tested whether the drug retatrutide can improve kidney function in 146 adults who are overweight or obese and have chronic kidney disease, with or without type 2 diabetes. Participants received the drug or a placebo for about 31 weeks. The main goal was to see if retat…

This early-stage study tested a new drug called CT-996 in 94 overweight or obese adults, including some with type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Researchers also looked at how it affects weight and blood sugar, but this is j…

This study tested an experimental pill called TERN-601 in 167 adults with overweight or obesity. The goal was to see if it helps with weight loss and is safe to take over 12 weeks. Participants took the pill or a placebo, and researchers measured changes in body weight and how ma…

This early-stage study tested a new injection called HRS-4729 in 102 healthy adults who were overweight or obese. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effec…

This study looked at 120 shift workers with prediabetes or type 2 diabetes who were overweight or obese. Participants followed one of three low-calorie diets for 12 weeks, each with a different amount of protein at dinner. The goal was to see which diet best improved blood sugar,…

This study tested whether a probiotic supplement called Akkermansia muciniphila Akk11 can help overweight or obese adults improve their metabolism and gut health. 110 participants took either the probiotic or a placebo daily. Researchers measured changes in key hormones related t…

This study compared a once-daily pill called orforglipron to insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had increased heart or kidney risk. The main goal was to see if orforglipron could delay or prevent major heart problems …

This study provided 580 Native American adults and children in the Osage Nation with weekly fresh produce, recipes, and cooking materials to improve diet and health. The program aimed to reduce diet-related diseases like high blood pressure and obesity. Results showed positive ch…

This study tested an experimental injection called ZT002 in 303 adults who are overweight or have obesity. The goal was to see how much weight people lost after 24 weeks of treatment compared to a placebo. The study also looked at how many people lost at least 5%, 10%, or 15% of …

This study looked at whether sleeping longer or keeping a regular sleep schedule can improve metabolic health and lower diabetes risk in overweight adults. Eighteen African American men and women who were short sleepers participated. Researchers measured changes in sleep patterns…

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This early-stage study tested the safety and tolerability of a new injectable drug called ZT002 in 28 adults who were overweight or obese. Participants received either the drug or a placebo, and researchers monitored for side effects and how the drug moved through the body. The g…

This study tested a program called eMOMS that combines breastfeeding support with a diabetes prevention plan. It was designed for pregnant women who were overweight or had obesity. The goal was to see if the program could help them lose weight after giving birth and breastfeed lo…

This study tested an online guided self-help program for teenagers aged 12 to 17 who have binge eating episodes and are above a healthy weight. Over four months, participants completed weekly online sessions and were interviewed afterward. The goal was to see if the program was p…

This study tested a special cooling pillow pad called Moona to see if it could improve sleep quality in African American adults who are overweight or have obesity. 18 people took part, and researchers measured changes in how fast they fell asleep, how long they slept, and other s…

This study tested two online cognitive behavioral therapy treatments for 25 adolescents with bulimia nervosa who also have higher weight. The goal was to see if the treatments were feasible and acceptable, and to measure changes in binge eating and purging behaviors. Participants…

This early-phase study looked at how AMG 133, an experimental drug, affects how quickly the stomach empties in people who are overweight or have obesity. Researchers gave the drug or a placebo to 57 adults and measured stomach emptying using a special marker. The goal was to unde…

This study tested whether a 6-month high-intensity functional training program is practical and helpful for overweight or obese adults who have a permanent disability that affects their mobility. 25 adults participated in the program three times per week. Researchers measured cha…

This study tested a new computer algorithm that uses data from wearable sensors and food diaries to predict a person's real-time risk of developing prediabetes. 77 overweight or obese adults wore glucose monitors and fitness trackers for 4 months. The goal was to see if the algor…