OVERWEIGHT OR OBESITY

This early-stage study tests two versions of an experimental tablet called HRS9531 in 168 overweight or obese men aged 18-55. The main goal is to compare how the body absorbs each version and to check for side effects. Participants must have a stable weight and a BMI between 24 a…

This study aims to help overweight or obese taxi and ride-share drivers lose weight. About 1,785 drivers will receive a combination of counseling, text messages, phone support, and self-monitoring tools. The goal is to find the most effective and affordable way to help this hard-…

This early-stage study tests a new drug called BGM1812 in 60 overweight or obese but otherwise healthy adults. The goal is to check the drug's safety, how the body processes it, and whether it leads to weight loss. Participants receive either the drug or a placebo injection under…

This early-phase study tests a new drug called LY4064912 in 144 healthy adults and people with overweight or obesity. The main goal is to check if the drug is safe and what side effects it may cause. Participants will receive the drug as a shot under the skin or through an IV, an…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab therapy helps adults with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 participants will receive both treatments for up to 12 months. The main goals are t…

This early-stage trial tests a new medicine called SYH9017 in 66 Chinese adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it after one or several doses. Participants receive either the drug or a placebo, and researchers …

This study tests a once-daily pill called orforglipron in people who have both high blood pressure and obesity or overweight. The goal is to see if it can lower blood pressure and help with weight loss. About 487 adults will take either the study drug or a placebo for several mon…

This study tests a new drug called olatorepatide in 120 adults who are overweight or obese but do not have diabetes. The goal is to see how safe the drug is, how the body processes it, and whether it helps with weight loss compared to a placebo. Participants will receive either t…

This study looks at whether combining a weight loss program with a walking exercise plan helps people with peripheral artery disease (PAD) and overweight walk farther after 12 months, compared to just walking exercise alone. About 212 adults with PAD and a BMI over 25 will take p…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab therapy helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive the combination for up to 12 months. The main goals are to see if more …

This study tests whether a weight loss injection (GZR18) given once every 4 weeks can safely help people continue losing weight. It includes 500 adults who already completed a year of treatment with the same drug. Participants will receive the injection for 24 weeks while maintai…

This early-stage study tests an experimental oral drug called RO7795081 in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to treat the condition. Participants will receive either the dru…

This early-stage study tests a new drug called KN069 in 36 Chinese men who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor weight, waist size…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AF) in overweight or obese adults. About 200 people aged 18-75 with AF and a BMI of 30 or higher will receive semaglutide alongside standard AF care. The goal is to see …

This study tests whether metformin, a common diabetes medicine, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). Researchers will give metformin or a placebo to 54 people aged 60-75 for 26 weeks. They will use brain scans a…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes over 12 months or receive st…

This early-stage study tests a new drug called BGM1812 in healthy and non-diabetic overweight or obese Chinese adults. The main goal is to check if the drug is safe and tolerable, and to see how it behaves in the body. About 60 participants will receive either the drug or a place…

This study tests whether people with overweight or obesity and high food cravings can learn to change their brain's response to food cues using neurofeedback. Participants will undergo brain scans while receiving real-time feedback to help reduce cravings. The goal is to see if t…

This phase 3 study tests a once-weekly injection called eloralintide in 900 adults who have both osteoarthritis of the knee and obesity or overweight. The goal is to see if the drug reduces knee pain and body weight compared to a placebo. Participants will be in the study for abo…

This early-stage study tests whether MWN109 tablets are safe and how they work in the body. It involves 60 healthy adults who are overweight or obese. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels. The goal is to gather sa…

This study looks at whether adding a whey protein-enriched milk fat globule membrane supplement to a high-fat meal can improve heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will attend two full-day visits, …

This study looks at whether adding a behavioral weight reduction program (diet, exercise, and behavior changes) to standard back pain treatment can help overweight or obese people with chronic low back pain. About 252 adults will be split into two groups: one gets the weight prog…

This study looks at whether changing people's automatic, unconscious feelings about exercise can help them become more active. Researchers will work with 120 adults who are overweight and currently inactive. Participants will wear a Fitbit and answer quick smartphone surveys to m…

This study observes 1,000 teens aged 12-17 in Miami-Dade County who join a park-based afterschool program. Researchers will track changes in mental health, physical fitness, and resilience over time. The goal is to understand if community park programs can improve overall well-be…