METASTATIC MELANOMA

This study tested a new type of vaccine for people with advanced melanoma, a serious skin cancer. The vaccine was made by fusing a patient's own immune cells (dendritic cells) with their cancer cells, aiming to teach the immune system to attack the tumor. The goal was to see if t…

This study tested whether combining oral azacitidine with pembrolizumab can help control advanced melanoma that has spread. It included 24 adults with metastatic melanoma, some who had never received PD-1 therapy and others whose cancer had worsened despite it. The goal was to se…

This early-stage trial tested whether combining a topical cream (imiquimod) with an immunotherapy drug (pembrolizumab) is safe and effective for people with advanced melanoma that cannot be surgically removed. Seven participants with stage IIIB to IV melanoma were enrolled. The s…

This study tested a new approach for people with advanced melanoma that cannot be removed by surgery or has spread. Doctors used a lower dose of two chemotherapy drugs (fludarabine and cyclophosphamide) to prepare the body, then infused the patient's own tumor-fighting immune cel…

This study tested a weekly dose of a chemotherapy drug called Taxoprexin in 22 people with advanced eye melanoma that had spread to other parts of the body. The goal was to see if the drug could shrink tumors and how long that effect might last. Researchers also tracked side effe…

This early-phase trial tested a new drug called IN10018, alone or with other medicines, in 51 adults with metastatic melanoma (skin cancer that has spread). The main goal was to check safety and how the body handles the drug. Researchers also looked for signs that the drug could …

This study tested a combination of two immunotherapy drugs, low-dose ipilimumab and pembrolizumab, in 24 people with advanced melanoma that had spread to the brain. The goal was to see if the treatment could shrink or control brain tumors and improve survival. Participants receiv…

This study tested a new treatment for people with advanced melanoma that has spread or cannot be removed by surgery. The treatment uses a patient's own immune cells, called tumor-infiltrating lymphocytes (TILs), which are grown in a lab and then infused back into the patient. The…

This study tested a weekly dose of a new chemotherapy drug called Taxoprexin in 30 people with advanced melanoma that had spread to other parts of the body. The goal was to see if the drug could shrink tumors and how long that effect might last. Researchers also tracked side effe…

This early study tested whether combining an immunotherapy drug (pembrolizumab) with precise radiation (stereotactic radiosurgery) is safe for people with melanoma or lung cancer that has spread to the brain. 25 participants received the combination. The main goal was to check fo…

This study tested an experimental treatment for metastatic melanoma that uses a patient's own immune cells (tumor-infiltrating lymphocytes) grown in a lab and then infused back. Participants received chemotherapy to weaken their immune system before the cell infusion, and some al…

This pilot study tested a new combination treatment for people with advanced melanoma that has spread. It combined immune cells grown from the patient's own tumor (called TILs) with an immunotherapy drug called ipilimumab. The goal was to see if this approach was safe and feasibl…

This early-phase study tested a new treatment called TBio-4101 for people with advanced melanoma that had stopped responding to standard therapies. The treatment uses a patient's own immune cells (TILs) that are selected and grown in the lab, then given back after chemotherapy to…

This study tested a powerful mix of a targeted drug (vemurafenib), specially grown immune cells (T-cells), and high-dose IL-2 in 17 people with advanced melanoma that had spread. The goal was to see if this combination could shrink tumors and keep patients alive longer. The appro…

This study tested a treatment for advanced melanoma that uses a patient's own immune cells (called TIL) grown in a lab and given back with high-dose IL-2. The goal was to see if this approach was possible and safe. 19 people with stage IV or stage III melanoma took part. The trea…

This study looked at whether a blood test could find genetic changes in people with advanced melanoma. Normally, doctors need to take a piece of the tumor (biopsy) to check for these changes, which can be painful and hard to do. The study tested blood samples from 50 patients to …

This study tested a counseling program called CALM (Managing Cancer and Living Meaningfully) for people with malignant brain cancer. The goal was to see if it's practical and helpful for reducing distress like depression and anxiety about death. 60 participants were offered eithe…

This study involved 5 people with advanced melanoma who were treated with immunotherapy drugs (nivolumab with or without ipilimumab). Researchers wanted to understand how the immune system changes during treatment and what makes some patients respond better than others. They took…

This study looked at whether people with advanced cancer (melanoma, kidney, or lung cancer) who are starting immunotherapy can collect tiny blood samples at home using a finger-prick method. The goal was to see if this approach is practical and if the samples are good enough for …

This study involved 32 people with advanced melanoma who were being treated with Anti-PD1 drugs (Nivolumab). The goal was to track changes in different immune cells (like dendritic cells and T cells) before and during treatment. By comparing those who responded well to those who …

This study compared two blood test methods (EPISPOT and CellSearch) to see how well they find circulating melanoma cells in people with advanced melanoma. Researchers took blood samples from 73 participants, including patients with stage 4 melanoma and hospitalized volunteers wit…

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before brain surgery is safe and feasible in people with melanoma that has spread to the brain. Only one person took part, so results are very limited. The main goal was to see …

This study observed about 400 adults with advanced BRAF-mutant melanoma who were taking targeted therapy (BRAF/MEK inhibitors) and using a smartphone app called TavieSkin. The goal was to describe patient characteristics, how they used the app, and their quality of life. No new t…

This study looked at 132 people with advanced melanoma to see if levels of a protein called interferon-gamma (IFN-γ) in tumor tissue and blood could predict how well they would respond to first-line immunotherapy drugs. Researchers also explored whether gut bacteria play a role i…